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| 1 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 2 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 3 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 4 | Novel approach to nonlinear non-Gaussian Bayesian state estimation显示文摘 | Gordon N J Salmond D J Smith A F M | 1993 | IEE Proceedings-F1993，140，2： | 2 |
| 5 | Novel Approach to Nonlinear/non-Gaussian Bayesian State Estimation显示文摘 | Gordon N J Salmond D J Smith AFM | 1993 | lEE Proc Inst Elect Eng F1993，140，2： | 1 |
| 6 | Novel approach to non-finear/non-Gnussian Bayesian state estimation显示文摘 | N J Gordon D J Salmond A F M Smith | 1993 | IEE Proceedings-F1993，140，2： | 1 |
| 7 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 8 | Novel approach to non-linear non-Gaussian Bayesian state estimation显示文摘 | Gordon N Salmond D Smith A | 1993 | IEEE Proceedings F1993，140，2： | 1 |
| 9 | Novel Ap- proach to Nonlinear/non-Gaussian Bayesian State Estimation显示文摘 | Gordon N J Salmond D J Smith A F M | 1993 | lEE Proceedings-F1993，140，2： | 1 |
| 10 | Novel approach to nonlinear/non-Gaussian Bayesian state estimation显示文摘 | GORDON N J SALMOND D J SMITH A F M | 1993 | IEE Proceedings on Radar and Signal Processing1993，140，2： | 1 |
| 11 | Novel ap-proach to nonlinear/non-gaussian bayesian state esti-mation显示文摘 | Gordon N J Salmond D J Smith A F M | 1993 | IEE Proceedings on Radar and SignalProcessing1993，140，2： | 1 |
| 12 | A novel approach to nonlinear1 non-gaussian bayesian state estimatior显示文摘 | Gordon N J Salmond D J Smith A F M | | 0，，： | 1 |
| 13 | Novel Approach to Nonlinear/Non-Gaussian Bayesian State Est-Imation显示文摘 | Gordon N J Salmond D J Smith A F M | 1993 | IEEE Proceedings-F1993，140，2： | 1 |
| 14 | Novel approach to nonlinear/non-Gaussian Bayesian state estimation显示文摘 | Salmond D J Smith A F M | | IEE Procedings F0，1993，： | 1 |
| 15 | Novel approach to non-linear and non- Gaussian Bayesian state estimation 显示文摘 | GORDON N SALMOND D | 1993 | Proceedings of Institute Electric Engineering1993，140，2： | 1 |
| 16 | Novel approach to nonlinear and non-Gaussian Bayesian state estimation显示文摘 | Gordon N Salmond D Smith A | 1993 | IEE Proceedings on Radar Sonar and Navigation1993，140，2： | 1 |
| 17 | Novel Approach to Nonlinear/Non-Gaussian Bayesian State Estimation显示文摘 | GORDON N J SECOND D J SgITH A F M | 1993 | IEEE Proceeding-F1993，140，02： | 1 |
| 18 | Novel approach to nonlinear and non-Gaussian Bayesian state estimation显示文摘 | Gordon N J Salmond D J | 1993 | Proc of Institute Engineering1993，140，2： | 1 |
| 19 | Novel approach to nonlinear/non-gaussian bayesian state estimation显示文摘 | GORDON N J SALMOND D J SMITH A F M | 1993 | IEE Proceedings -F1993，140，2： | 1 |
| 20 | Persistent anomalies of the extratropieal northern hemisphere wintertime eireulation: Geographieal distribution and regional persistenee eharaeteristies 显示文摘 | Dole R M N D Gordon | 1983 | Mon Wea Rev1983，111，： | 1 |
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