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| 1 | Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke显示文摘Introduction: Increased blood pressure variability (BPV) is detrimental after acute ischaemic stroke, but the interaction between BPV and neuroimaging factors that directly influence stroke outcome has not been explored. Methods: We retrospectively reviewed inpatients from 2007 to 2014 with acute anterior circulation ischaemic stroke, CT perfusion and angiography at hospital admission, and a modified Rankin Scale (MRS) 30- 365 days after stroke onset. BPV indices included SD, coefficient of variation and successive variation of the systolic blood pressure between 0 and 120 hours after admission. Ordinal logistic regression models were fitted to MRS with predictor variables of BPV indices. Models were further stratified by CT perfusion volumetric measurements, proximal vessel occlusion and collateral score. Results: 110 patients met the inclusion criteria. The likelihood of a 1-point rise in the MRS increased with every 10 mm Hg increase in BPV (OR for the 3 BPV indices ranged from 2.27 to 5.54), which was more pronounced in patients with larger ischaemic core volumes (OR 8.37 to 18.0) and larger hypoperfused volumes (OR 6.02 to 15.4). This association also held true for patients with larger mismatch volume, proximal vessel occlusion and good collateral vessels. Conclusions: These results indicate that increased BPV is associated with worse neurological outcome after stroke, particularly in patients with a large lesion core volume, concurrent viable ischaemic penumbra, proximal vessel occlusion and good collaterals. This subset of patients, who are often not candidates for or fail acute stroke therapies such as intravenous tissue plasminogen activator or endovascular thrombectomy, may benefit from interventions aimed at reducing BPV. | Adam de Havenon Alicia Bennett Gregory J Stoddard Gordon Smith Lee Chung Steve O’Donnell J Scott McNally David Tirschwell Jennifer J Majersik | 2017 | Stroke & Vascular Neurology2017，2，1： | 6 |
| 2 | 阿司匹林及氯吡格雷双抗与阿司匹林单药治疗急性轻度缺血性卒中及高危短暂性脑缺血发作的比较:系统综述及meta分析显示文摘目的为了评估对于急性轻度缺血性卒中及短暂性脑缺血发作(TIA)患者应用联合阿司匹林及氯吡格雷双抗治疗,相较于单用阿司匹林,预防血栓再发及出血事件的有效性及安全性。研究设计对随机、安慰剂对照研究进行系统综述及meta分析。 | Qiukui Hao Malavika Tampi Martin O' Donnell Farid Foroutan Reed AC Siemieniuk Gordon Guyatt 李洁(译) 毛晨晖(校) | 2019 | 英国医学杂志中文版2019，22，5： | 5 |
| 3 | Anterior ankle arthrodesis显示文摘Ankle arthrodesis is a common procedure that resolves many conditions of the foot and ankle; however, complications following this procedure are often reported and vary depending on the fixation technique. Various techniques have been described in the attempt to achieve ankle arthrodesis and there is much debate as to the efficiency of each one. This study aims to evaluate the efficiency of anterior plating in ankle arthrodesis using customised and Synthes Tomo Fix plates. We present the outcomes of 28 ankle arthrodeses between 2005 and 2012, specifically examining rate of union, patient-reported outcomes scores, and complications. All 28 patients achieved radiographic union at an average of 36 wk; the majority of patients(92.86%) at or before 16 wk, the exceptions being two patients with Charcot joints who were noted to have bony union at a three year review. Patient-reported outcomes scores significantly increased(P < 0.05). Complications included two delayed unions as previously mentioned, infection, and extended postoperative pain. With multiple points for fixation and coaxial screw entry points, the contoured customised plate offers added compression and provides a rigid fixation for arthrodesis stabilization. | Gordon L Slater Stephanie C Sayres Martin J O'Malley | 2014 | World Journal of Orthopedics2014，5，1： | 5 |
| 4 | Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage显示文摘AIM:To describe the prevalence,diagnosis,treatment,and outcomes of end stage liver disease(ESLD) patients with severe epistaxis thought to be severe upper gastrointestinal hemorrhage(UGIH).METHODS:This observational single center study included all consecutive patients with ESLD and epistaxis identified from consecutive subjects hospitalized with suspected UGIH and prospectively enrolled in our databases of severe UGIH between 1998 and 2011.RESULTS:A total of 1249 patients were registered for severe UGIH in the data basis,461(36.9%) were cirrhotics. Epistaxis rather than UGIH was the bleeding source in 20 patients. All patients had severe coagulopathy. Epistaxis was initially controlled in all cases. Fifteen(75%) subjects required posterior nasal packing and 2(10%) embolization in addition to correction of coagulopathy. Five(25%) patients died in the hospital,12(60%) received orthotopic liver transplantation(OLT),and 3(15%) were discharged without OLT. The mortality rate was 63% in patients without OLT.CONCLUSION:Severe epistaxis in patients with ESLD is(1) a diagnosis of exclusion that requires upper endoscopy to exclude severe UGIH;and(2) associated with a high mortality rate in patients not receiving OLT. | Marine Camus Dennis M Jensen Jason D Matthews Gordon V Ohning Thomas O Kovacs Rome Jutabha Kevin A Ghassemi Gustavo A Machicado Gareth S Dulai | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 5 | Sofosbuvir and Ribavirin Prevent Recurrence of HCV Infection after Liver Transplantation: An Open-Label Study显示文摘 | Michael P. Curry Xavier Forns Raymond T. Chung Norah A. Terrault Robert Brown Jonathan M. Fenkel Fredric Gordon Jacqueline O’Leary Alexander Kuo Thomas Schiano Gregory Everson Eugene Schiff Alex Befeler Edward Gane Sammy Saab John G. McHutchison G. Mani S | 2014 | Gastroenterology2014，，： | 3 |
| 6 | Lymphocytic esophagitis: Still an enigma a decade later显示文摘Lymphocytic esophagitis (LE) is a clinicopathologic entity first described by Rubio et al in 2006. It is defined as peripapillary intraepithelial lymphocytosis with spongiosis and few or no granulocytes on esophageal biopsy. This definition is not widely accepted and the number of lymphocytes needed to make the diagnosis varied in different studies. Multiple studies have described potential clinical associations and risk factors for LE, such as old age, female gender and smoking history. This entity was reported in inflammatory bowel disease in the pediatric population but not in adults. Other associations include gastroesophageal reflux disease and primary esophageal motility disorders. The most common symptom is dysphagia, with a normal appearing esophagus on endoscopy, though esophageal rings, webs, nodularities, furrows and strictures have been described. Multiple treatment modalities have been used such as proton pump inhibitors and topical steroids. Esophageal dilation seems to be therapeutic when dysphagia is present along with esophageal narrowing secondary to webs, rings or strictures. The natural history of the disease remains unclear and needs to be better delineated. Overall, lymphocytic esophagitis seems to have a chronic and benign course, except for two cases of esophageal perforation in the literature, thought to be secondary to this entity. | Carol Rouphael Ilyssa O Gordon Prashanthi N Thota | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 7 | Delayed reconstruction of lateral complex structures of the ankle显示文摘Lateral ankle instability is one of the most common and well-recognized conditions presenting to foot and ankle surgeons.It may exist as an isolated entity or in conjunction with other concomitant pathology,making it important to appropriately diagnose and identify other conditions that may need to be addressed as part of treatment.These associated conditions may be a source of chronic pain,even when the instability has been appropriately treated,or may lead to failure of treatment by predisposing the patient to ankle inversion injuries.The primary goal of this editorial is to provide a brief summary of the common techniques used in the delayed reconstruction of lateral ankle ligamentous injuries and present a method we have successfully employed for over 15 years.We will also briefly discuss the diagnosis and treatment of the more common associated conditions,which are important to identify to achieve satisfactory results for the patient.We present the outcomes of 250 consecutive reconstructions performed over the last 10 years and describe our operative technique for addressing lateral ankle ligamentous injuries. | Gordon L Slater Alejandro E Pino Martin O’Malley | 2011 | World Journal of Orthopedics2011，2，4： | 2 |
| 8 | A computerized classification technique for screening for the presence of breath bio- markers in lung cancer显示文摘 | O'Neill H J Gordon S M O'Neill M H | 1988 | Clin Chem1988，34，： | 1 |
| 9 | Expected and unexpected stressors in major international competition:appraisal coping,and performance显示文摘 | GORDON S | 2000 | The Sport Psychologist2000，，16： | 1 |
| 10 | Assigning Escherichia coli strains to phylogenetic groups:multilocus sequence typing versus the PCR triplex method显示文摘 | Gordon DM Clermont O Tolley H | 2008 | Environ Microbiol2008，10，10： | 1 |
| 11 | A semianalyt- ic radiance model of ocean color显示文摘 | Gordon H R Brown O B Evans R H | 1988 | Journal of Geophysi- cal Research1988，93，10： | 1 |
| 12 | Materials studies in a high energy spark gap显示文摘 | GORDON L B KRISTIANSEN M HAGLER M O | 1982 | IEEE Transactions on Plasma Science1982，10，4： | 1 |
| 13 | Synthesis and characterization of zinc/iron oxide composite nanoparticles and their antibacterial properties显示文摘 | Gordon T Perlstein B Houbara O Felner I Banin E Margel S | 2011 | Colloid Surface A2011，374，： | 1 |
| 14 | A semlanalytic radiance model of ocean color显示文摘 | Gordon H R Brown O B Evans R H | 1988 | Journal of Geophysical Research1988，93，10： | 1 |
| 15 | Release of iron from phosvitin by heat and food additives显示文摘 | Albright K J Gordon D T Cotterill O J | 1984 | Food Sci1984，，49： | 1 |
| 16 | Computed rela- tionships between the inherent and apparent optical prop- erties of a flat homogeneous ocean显示文摘 | Gordon H R Brown O B Jacobs M M | 1975 | Applied Optics1975，14，2： | 1 |
| 17 | Psychophysiology显示文摘 | Gordon I Zagoory-Sharon O Schneiderman I Leckman J F Weller A Feldman R | 2008 | 45(3):3492008，45，3： | 1 |
| 18 | A semi-analytic radiance model of ocean color显示文摘 | Gordon H R Brown O B Evans R H | 1988 | Journal of Geophysics Research1988，93，10： | 1 |
| 19 | The ocular hypertension treatment study显示文摘 | GORDON M O BEISER J A BRAND J D | 2002 | Arch Ophthalmol2002，120，6： | 1 |
| 20 | A semi-analytic radiance model of ocean color显示文摘 | Gordon H R Brown O B Evans R H | 1988 | Journal of Geophysical Research s1988，93，10： | 1 |
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