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| 1 | Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report显示文摘 | Pierre-Alain Clavien Mickael Lesurtel Patrick MM Bossuyt Gregory J Gores Bernard Langer Arnaud Perrier | 2012 | Lancet Oncology2012，，1： | 13 |
| 2 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 3 | Proteasome inhibition-induces endoplasmic reticulum dysfunction and cell death of human cholangiocarcinoma cells显示文摘AIM: To determine if proteasome inhibition induces apoptosis in human cholangiocarcinoma cells, and if so, to elucidate the cellular mechanisms. METHODS: Studies were performed in the human KMCH, KMBC, and Mz-ChA-1 cholangiocarcinoma, and normal rat cell lines. MG132, a peptide aldehyde, which inhibits the chymotrypsin-like activity of the proteaosome was employed for this study. Apoptosis was assessed morphologically by 4'-6-Diamidino-2-phenylindole (DAPI) nuclear staining and fluorescence microscopy. Mitochondrial membrane potential was examined using a fluorescent unquenching assay. Ultrastructural changes during cell death were examined using transmission electron microscopy (TEM). Caspase 3/7 activity was assessed using an enzymatic-based fluorescent assay. Cytosolic-free calcium concentrations were measured using Fura-2 and digitized fluorescent microscopy. RESULTS: MG132, a proteasome inhibitor, induced apoptosis in all the cholangiocarcinoma cell lines examined. In contrast, minimal cytotoxicity was observed in normal rat cholangiocytes. Apoptosis was time-and -concentration-dependent. There was no change in the mitochondrial membrane potential between treated and untreated cells. Ultrastructural examination by transmission electron microscopy displayed the classic features of apoptosis, but in addition, there was also dramatic vacuolization of the endoplasmic reticulum (ER). Unexpectedly, no increase in caspase 3/7 activity was observed in MG132 treated cells, nor did the pancaspase inhibitor, Q-VD-OPh prevent cell death. The protein synthesis inhibitor, cycloheximide, blocked apoptosis induced by proteosome inhibitor indicating that ER dysfunction was dependent upon the formation of new proteins. CONCLUSION: Proteosome inhibition induces ERdysfunction and caspase-independent cell death selectively in human cholangiocarcinoma cells. Proteasome inhibitors warrant evaluation as anticancer agents for the treatment of human cholangiocarcinoma. | Yucel Ustundag Steven F Bronk Gregory J Gores | 2007 | World Journal of Gastroenterology2007，13，6： | 9 |
| 4 | Constitutive androstane receptor agonist, TCPOBOP,attenuates steatohepatitis in the methionine choline-deficientdiet-fed mouse显示文摘AIM:To ascertain whether constitutive androstane receptor(CAR)activation by 1,4-bis-2-(3,5,-dichloropyridyloxy)benzene(TCPOBOP)modulates steatohepatitis in the methionine choline-deficient(MCD)diet-fed animal.METHODS:C57/BL6 wild-type mice were fed the MCD or standard diet for 2 wk and were treated with either the CAR agonist,TCPOBOP,or the CAR inverse agonist,androstanol.RESULTS:Expression of CYP2B10 and CYP3A11,known CAR target genes,increased 30-fold and 45-fold,respectively,in TCPOBOP-treated mice fed the MCD diet.TCPOBOP treatment reduced hepatic steatosis(44.6 ± 5.4% vs 30.4 ± 4.5%,P < 0.05)and serum triglyceride levels(48 ± 8 vs 20 ± 1 mg/dL,P < 0.05)in MCD diet-fed mice as compared with the standard diet-fed mice.This reduction in hepatic steatosis was accompanied by an increase in enzymes involved in fatty acid microsomal ω-oxidation and peroxisomal β-oxidation,namely CYP4A10,LPBE,and 3-ketoacyl-CoA thiolase.The reduction in steatosis was also accompanied by a reduction in liver cell apoptosis and inflammation.In contrast,androstanol was without effect on any of the above parameters.CONCLUSION:CAR activation stimulates induction of genes involved in fatty acid oxidation,and ameliorates hepatic steatosis,apoptosis and inflammation. | Edwina S Baskin-Bey Akira Anan Hajime Isomoto Steven F Bronk Gregory J Gores | 2007 | World Journal of Gastroenterology2007，13，42： | 3 |
| 5 | Cholangiocarcinoma显示文摘 | Nataliya Razumilava Gregory J Gores | 2014 | The Lancet2014，，： | 2 |
| 6 | Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study显示文摘 | Pierre Fenaux Ghulam J Mufti Eva Hellstrom-Lindberg Valeria Santini Carlo Finelli Aristoteles Giagounidis Robert Schoch Norbert Gattermann Guillermo Sanz Alan List Steven D Gore John F Seymour John M Bennett John Byrd Jay Backstrom Linda Zimmerman David M | 2009 | Lancet Oncology2009，，： | 2 |
| 7 | Synthesis of putative intermediates in the biosynthesis of the kinamycin antibiotics: total synthesis of phenanthroviridn aglycon and related compounds显示文摘 | GORE M P GOULD S J WELLER D D | 1992 | J Org Chem1992，57，： | 2 |
| 8 | Topotecan versus paclitaxel for the treatment of reccurent epithelial ovarian cancer显示文摘 | GORE M CARMICHAEL J GORDON A | 1997 | Clin Oncol1997，15，6： | 1 |
| 9 | Use of clomiphene and luteinizing hormone/follicle stimulating hormone-releasing hormone in investigation of ovulatory failure 显示文摘 | Ginsburg J Isaacs A J Gore MB | 1975 | Br Med J1975，3，5976： | 1 |
| 10 | Hepatocellular carcinoma:clinical frontiers and perspectives 显示文摘 | Bruix J Gores GJ Mazzaferro V | 2014 | Gut2014，63，5： | 1 |
| 11 | Lysosomes in cell death 显示文摘 | Guicciardi M E Leist M Gores G J | 2004 | Oncogene2004，23，16： | 1 |
| 12 | Minimization ofregion-scalable fitting energy for image segmentation 显示文摘 | Li Chunming Kao C Y Gore J C | 2008 | IEEE Trans on Image Processing2008，17，10： | 1 |
| 13 | Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report显示文摘 | Pierre-Alain Clavien Mickael Lesurtel Patrick MM Bossuyt Gregory J Gores Bernard Langer Arnaud Perrier | 2012 | Lancet Oncology2012，，1： | 1 |
| 14 | Minimization of region-scalable fitting energy for image segmentation 显示文摘 | LI C KAO C GORE J | 2008 | IEEE Transactions on Image Processing2008，17，10： | 1 |
| 15 | Clinical evidence for topotecan-paclitaxel non-cross-resistance in ovarian cancer 显示文摘 | Huinink WB Garmichael J | 2001 | J Clin Oncol2001，19，7： | 1 |
| 16 | Endurance training altars antioxidant enzyme gene expression in rat skeletal muscle显示文摘 | Gore M Fiebig R Hollander J | 1998 | Can J Physiol Pharmacol 1998 Dec1998，76，12： | 1 |
| 17 | A new class of electrochemically and thermally stable lithium salts for lithium battery electrolytes显示文摘 | Barthel J Schmid A Gores H J | 2000 | J Electrochem Soc2000，147，1： | 1 |
| 18 | Two members of the thioredoxin-h family interact with the kinase domain of a Brassica S-locus receptor kinase 显示文摘 | Bower M S Matias D D Femandes-carvalho E Mazzurco M Gu T Rothstein A J and Goring D R | 1996 | Plant Cell1996，8，： | 1 |
| 19 | Minimization of region-scalable fitting energy for image segmentation 显示文摘 | Li C M Kao C Y Gore J C | 2008 | 1EEE Transactions on Image Pro- cessing2008，17，10： | 1 |
| 20 | Minimization of region-scala- ble fitting energy for image segmentation 显示文摘 | Li C M Kao C Y Gore J C et at | 2008 | IEEE Transactions on Image Processing2008，17，10： | 1 |
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