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| 1 | Interleukin-12 as a Genetic Adjuvant Enhances Hepatitis C Virus NS3 DNA Vaccine Immunogenicity显示文摘Hepatitis C virus (HCV) chronic infection is a worldwide health problem, and numerous efforts have been invested to develop novel vaccines. An efficient vaccine requires broad immune response induction against viral proteins. To achieve this goal, we constructed a DNA vaccine expressing nonstructural 3 (NS3) gene (pcDNA3.1-HCV-NS3) and assessed the immune response in C57BL/6 mice. In this study, the NS3 gene was amplified with a nested-reverse transcriptase-polymerase chain reaction (RT-PCR) method using sera of HCV-infected patients with genotype 1a. The resulting NS3 gene was subcloned into a pcDNA3.1 eukaryotic expression vector, and gene expression was detected by western blot. The resultant DNA vaccine was co-administered with interleukin-12 (IL-12) as an adjuvant to female C57BL/6 mice. After the final immunizations, lymphocyte proliferation, cytotoxicity, and cytokine levels were assessed to measure immune responses. Our data suggest that co-administration of HCV NS3 DNA vaccine with IL-12 induces production of significant levels of both IL-4 and interferon (IFN)-γ (p<0.05). Cytotoxicity and lymphocyte proliferation responses of vaccinated mice were significantly increased compared to control (p<0.05). Collectively, our results demonstrated that co-administration of HCV NS3 and IL-12 displayed strong immunogenicity in a murine model. | Malihe Naderi Atefeh Saeedi Abdolvahab Moradi Mishar Kleshadi Mohammad Reza Zolfaghari Ali Gorji Amir Ghaemi | 2013 | Virologica Sinica2013，28，3： | 5 |
| 2 | Fabrication and mechanical properties of MWCNTs-reinforced aluminum composites by hot extrusion显示文摘Over the past decade,the interest in aluminum composites reinforced with carbon nanotubes has grown significantly.Studies have been carried out to overcome problems with uniform dispersion,interfacial bonding,void formation and carbide formation of the composites.In the present work,multi-wall carbon nanotubes(MWCNTs) aluminum composites were produced.High-energy ball milling with the aim at developing well-dispersed MWCNTs Al composites was followed by cold compaction,sintering,and hot extrusion at 500 ℃.Different amounts of stearic acid as processing control agent(PCA) is used in order to minimize cold welding of the Al particles,and to produce finer particles.Differential scanning calorimetry(DSC),scanning electron microscopy(SEM),transmission electron microscopy(TEM),and X-ray diffraction(XRD) were employed to analyze the MWCNTs,the aluminum powder,and the composites' microstructural behavior.The hardness and tensile properties of the composites are also evaluated.The results showed 500% increase in yield stress after the addition of 1 wt% MWCNTs in Al-MWCNTs based composite.The ball-milling time of 4 h is found to be sufficient as excessive milling time destroys a vast number of MWCNTs. | Mortazavi Majid Majzoobi G.H. Golikand A.Noozad Reihani A. Mortazavi S.Z. Gorji M.S. | 2012 | Rare Metals2012，31，4： | 4 |
| 3 | Application of Rice Husk Biochar for Achieving Sustainable Agriculture and Environment显示文摘This paper critically reviewed the current knowledge and challenges of rice husk biochar(RHB)production and its effects on soil properties,plant growth,immobilization of heavy metals,reduction of nutrient leaching and mitigation of greenhouse gas emissions.The characteristics of RHBs produced at various pyrolysis temperatures were discussed and compared to biochars derived from other agro-industrial wastes.RHBs produced at higher pyrolysis temperatures show lower hydrogen/carbon ratio,which suggests the presence of higher aromatic carbon compounds.The increase of pyrolysis temperature also results in production of RHBs with higher ash content,lower yield and higher surface area.RHB usually has higher silicon and ash contents and lower carbon content compared to biochars derived from other feedstocks at the same pyrolysis conditions.Although it depends on soil type,RHB application can improve soil organic carbon content,cation exchange capacity,available K concentration,bulk density and microbial activity.The effect of RHB on soil aggregation mainly depends on soil texture.The growth of different crops is also enhanced by application of RHB.RHB addition to soil can immobilize heavy metals and herbicides and reduce their bioavailability.RHB application shows a significant capacity in reduction of nitrate leaching,although its magnitude depends on the biochar application rate and soil biogeochemical characteristics.Use of RHB,especially in paddy fields,shows a promising mitigation effect on greenhouse gas(CH4,CO2 and N2O)emissions.Although RHB characteristics are also related to other factors such as pyrolysis heating rate and residence time,its performance for specific applications(e.g.carbon sequestration,pH amendment)can be manipulated by adjusting the pyrolysis temperature.More research is needed on long-term field applications of RHB to fully understand the advantages and disadvantages of RHB as a soil amendment. | Hossein Asadi Mohammad Ghorbani Mehran Rezaei-Rashti Sepideh Abrishamkesh Elnaz Amirahmadi Chen Chengrong Manouchehr Gorji | 2021 | Rice science2021，28，4： | 4 |
| 4 | Dental stem cells:The role of biomaterials and scaffolds in developing novel therapeutic strategies显示文摘Dental stem cells(DSCs)are self-renewable cells that can be obtained easily from dental tissues,and are a desirable source of autologous stem cells.The use of DSCs for stem cell transplantation therapeutic approaches is attractive due to their simple isolation,high plasticity,immunomodulatory properties,and multipotential abilities.Using appropriate scaffolds loaded with favorable biomolecules,such as growth factors,and cytokines,can improve the proliferation,differentiation,migration,and functional capacity of DSCs and can optimize the cellular morphology to build tissue constructs for specific purposes.An enormous variety of scaffolds have been used for tissue engineering with DSCs.Of these,the scaffolds that particularly mimic tissue-specific micromilieu and loaded with biomolecules favorably regulate angiogenesis,cell-matrix interactions,degradation of extracellular matrix,organized matrix formation,and the mineralization abilities of DSCs in both in vitro and in vivo conditions.DSCs represent a promising cell source for tissue engineering,especially for tooth,bone,and neural tissue restoration.The purpose of the present review is to summarize the current developments in the major scaffolding approaches as crucial guidelines for tissue engineering using DSCs and compare their effects in tissue and organ regeneration. | Cornelia Larissa Granz Ali Gorji | 2020 | World Journal of Stem Cells2020，12，9： | 3 |
| 5 | Effect of soil pore size distribution on plant-available water and least limiting water range as soil physical quality indicators显示文摘Soil pore size distribution(SPSD) is one of the most important soil physical properties. This research investigated the relationships of location and shape parameters of the SPSD curves with plant-available water(PAW) and least limiting water range(LLWR) of the light-textured soils at the Torogh Agricultural Research Station in north-eastern Iran. Soil moisture release curve(SMRC), PAW and LLWR in matric heads of 100 and 330 h Pa for the field capacity and location and shape parameters of the SPSD curves of 30 soils with different texture and organic carbon contents were determined, and the variable relationships were statistically analyzed. The results showed that the median equivalent pore diameter(de), mean de, standard deviation(SD*), and skewness of the SPSD curves were significantly correlated with PAW(PAW330) and LLWR(LLWR330) measured in a matric head of 330 h Pa. Decrease in deand increase in the diversity of soil pore size(SD*) increased PAW330 and LLWR330. The SD* values of all the soil samples were lower than the optimal ranges suggested in literature. Neither PAW nor LLWR values were significantly different in the soils with the optimal modal deand those with non-optimal modal de. Optimal values of median and mean equivalent pore diameters and kurtosis of SPSD curves led to a significant improvement of PAW330 and LLWR330 as soil physical quality indicators. It was recommended to revise the optimal ranges for SD* and modal defor future studies. | Mehdi ZANGIABADI Manoochehr GORJI Mehdi SHORAFA Saeed KHAVARI KHORASANI Saeed SAADAT | 2020 | Pedosphere2020，30，2： | 2 |
| 6 | Polyethylenimine-impregnated mesoporous silica:effect of amine loading and surface alkyl chains on CO2adsorption显示文摘 | Heydari Gorji A Belmabkhout Y Sayari A | 2011 | Langmuir2011，27，12： | 1 |
| 7 | Epileptogenic effect of cyclosporine in guinea-pig hippocampal slices 显示文摘 | Gorji A Scheld HH Speckmann EJ | 2002 | Neuroscience2002，115，4： | 1 |
| 8 | A simple model for the photocurrent density of a graded band gap CIGS thin film solar cell显示文摘 | Nima E. Gorji Ugo Reggiani Leonardo Sandrolini | 2011 | Solar Energy2011，，3： | 1 |
| 9 | The usefulness of intraoperative neurophysiological monitoring in cervical spine surgery: a ret- rospective analysis of 200 consecutive patients 显示文摘 | Li F Gorji R Allott G | 2012 | J Neuro- surg Anesthesiol2012，24，3： | 1 |
| 10 | Familial hemiplegic migraine and spreading depression显示文摘 | Kazemi H Speckmann EJ Gorji A | 2014 | Iran J Child Neurol2014，8，3： | 1 |
| 11 | The usefulness of intraoperative neurophysiological monitoring in cervical spine surgery:a retro- spective analysis of 200 consecutive patients 显示文摘 | Li F Gorji R Allott G | 2012 | J Neurosurg Anesthesiol2012，24，3： | 1 |
| 12 | Psychiatry and psychology in medieval Persia显示文摘 | Vakili N Gorji A | 2006 | J Clin Psychiatry2006，67，12： | 1 |
| 13 | Using the servicequality gap,s model ( SERVQUAL ) in Imam Khomeiniteaching hospital : 2012 显示文摘 | Gorji H A Tabatabaei S M Akbari A | 2013 | Journal of HealthAdministration ’2013，16，51： | 1 |
| 14 | Fabrication and characterization of polyurethane electrospun nanofiber membranes for protective clothing applications显示文摘 | GORJI M JEDDI A GHAREHAGHAJI A A | 2012 | Journal of Applied Polymer Science2012，125，5： | 1 |
| 15 | Hamartomatous polyps:Diagnosis,surveillance,and management显示文摘Hereditary polyposis syndrome can be divided into three categories:Adenomatous,serrated,and hamartomatous polyps.Hamartomatous polyps,malformations of normal tissue presenting in a disorganized manner,are characterized by an autosomal dominant inheritance pattern.These syndromes exhibit hamartomatous gastrointestinal polyps in conjunction to extra-intestinal manifestations,which require conscientious and diligent monitoring.Peutz-Jeghers syndrome,Cowden syndrome,and juvenile polyposis syndrome are the most common displays of hamartomatous polyposis syndrome(HPS).Diagnosis can be pursued with molecular testing and endoscopic sampling.Early identification of these autosomal dominant pathologies allows to optimize malignancy surveillance,which helps reduce morbidity and mortality in both the affected patient population as well as at-risk family members.Endoscopic surveillance is an important pillar of prognosis and monitoring,with many patients eventually requiring surgical intervention.In this review,we discuss the diagnosis,surveillance,and management of HPS. | Leva Gorji Peter Albrecht | 2023 | World Journal of Gastroenterology2023，29，8： | 1 |
| 16 | Spinal and cortical spread- ing depression enhance spinal cord activity 显示文摘 | Gorji A Zahn PK Pogatzki EM | 2004 | Neurobiol Dis2004，1，5： | 1 |
| 17 | Micromechanical consideration of interface damage in fiber reinforced Ti-al-loy under various combined loading conditions 显示文摘 | Aghdanm M M Falahatgar S R Gorji M | 2008 | Com-posites Science and Technology2008，，68： | 1 |
| 18 | The usefulness of intraoperative neurophysiological monitoring in cervical spine surgery:a retrospective analysis of 200 consecutive patients显示文摘 | Li F Gorji R Allott G | 2012 | J Neurosurg Anesthesiol2012，24，3： | 1 |
| 19 | The usefulness of intraoperative neurophysiological monitoring in cervical spine surgery: a retrospective analysis of 200 consecutive patients显示文摘 | Li F Gorji R Allott G | 2012 | J Neurosurg Anesthesiol2012，24，3： | 1 |
| 20 | The glutathione-S-transferase P1 polymorphisms correlates with changes in expression of TP53 tumor suppressor in cutaneous basal cell carcinoma 显示文摘 | Gorji H Shahbazi N Habibollahi P | 2009 | J Dermatol Sci2009，56，3： | 1 |
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