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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | 天然气自热重整模块化流化床膜反应器的测试显示文摘针对燃料电池等行业对分布式高纯度氢气的需求,研发了一种新型模块化流化床膜反应器用于中小规模天然气水蒸汽自热重整制氢。在一个天然气制氢测试平台上对该反应器进行了中试研究,测试了空气引入方式对床层温度均匀性的影响,钯膜组件及催化剂的工作性能,并将反应器尾气成分与平衡态最小自由能模型预测的结果进行了比较。测试结果表明该新型模块化流化床膜反应器适于天然气自热重整制氢。 | 解东来 Adris A M Lim C J Grace J R | 2009 | 太阳能学报2009，30，5： | 6 |
| 3 | Sequence and spacing of TATA box elements are critical for accurate initiation from the β-phaseolin promoter显示文摘 | GRACE M L CHANDRASEKHARAN M B HALL T C CROWE A J | 2004 | Biological Chemistry2004，279，： | 1 |
| 4 | Mierostruetural aspects of the behavior of circulating fluidized beds显示文摘 | Brereton C M H Grace J R | 1993 | Chemical Engineer-ing Science1993，48，14： | 1 |
| 5 | Effects of NPY on energy metabolism显示文摘 | Billington C J Briggs J Grace M etal | 1991 | Am J Physiol1991，260，： | 1 |
| 6 | Voluntary disclosure by state-owned enterprises listed on the Stock Exchange of Hong Kong 显示文摘 | Michael J F Kevin C K Grace M L | 2002 | Journal of International Financial Management and Accounting2002，13，2： | 1 |
| 7 | Structure of the N terminal domain of a type B1 G protein coupled receptor in com plex with a peptide ligand 显示文摘 | Grace C R R Perrin M H Gulyas J | 2007 | P Nat Acad Sci2007，104，12： | 1 |
| 8 | Prediction of internode length in Pinus radiata stands显示文摘 | GRACE J C CARSON M J | 1993 | N Z J For Sci1993，23，： | 1 |
| 9 | Gas and particlecirculation in an internally circulating fluidized bedmembrane reactor cold model 显示文摘 | Xie D Lim C J Grace J R Adris A E M | 2009 | Chemical EngineeringScience2009，64，： | 1 |
| 10 | All trans retinoic acid and cancer 显示文摘 | Siddikuzzaman Guruvayoorappan C Berlin Grace V M | 2011 | Immunopharmacol Immunotoxicol2011，33，2： | 1 |
| 11 | CD44V6:a potential marker of malignant transformation in intestinal metaplasia of the stomach? An immunohistochemical study using tissue microarrays显示文摘 | Grace A Leader M | 2003 | Eur J Gastroenterol Hepatol2003，15，9： | 1 |
| 12 | Adenomatous polyposis coli gene, beta-catenin, and E-cadherin expression in proximal and distal gastric cancers and precursor lesions: an immunohistochemical study using tissue microarrays 显示文摘 | Gulmann C Grace A Leader M | 2003 | Appl Immunohistochem Mol Morphol2003，11，3： | 1 |
| 13 | Pitch and coke combustion in a circulating fluidized bed显示文摘 | Brereton C M H Lim C J Grace J R | | 0，，10： | 1 |
| 14 | Human in vivo radiation-induced biomarkers: gene expression changes in radiotherapy patients 显示文摘 | Amundson S A Grace M B McLeland C B | 2004 | Cancer Research2004，64，18： | 1 |
| 15 | Real-time quantitative RT-PCR assay of GADD45 gene expression changes as a biomarker for radiation biodosimetry显示文摘 | Grace M B Mcleland C B Blakely W F | 2002 | Int J Radiat Biol2002，7，11： | 1 |
| 16 | Potential net primary productivity in South America: Application of a global model 显示文摘 | Rastetter E B Melillo J M Kicklighter D W Steudler P A Pteterson B J Grace A L Moore I B Vorosmarty C J | 1991 | Ecological Applications1991，1，： | 1 |
| 17 | Ring size of somatostatinanalogues (ODT-8) modulates receptor selectivity and bindingaffinity 显示文摘 | Erchegyi J Grace C R R Samant M | 2008 | Journal of medicinal chemistry2008，51，9： | 1 |
| 18 | Plant phenolic antioxidant and prooxidant activities: phenolics-induced ox-idative damage med- iated by metals in plants 显示文摘 | Sakihama Y Cohen M F Grace S C | 2002 | Toxicology2002，177，1： | 1 |
| 19 | Oxidation of volatile organic compounds by negative air ions显示文摘 | Chih C W Grace W M L | 2004 | Atmospheric Environment2004，38，： | 1 |
| 20 | Anti-radon coating for mitigating indoor radonconcentration 显示文摘 | GRACE W W GAOY H TANG C M | 2008 | Atmospheric Environment2008，42，37： | 1 |
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