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| 1 | Applications of finite element simulation in orthopedic and trauma surgery显示文摘Research in different areas of orthopedic and trauma surgery requires a methodology that allows both a more economic approach and the ability to reproduce different situations in an easy way. Simulation models have been introduced recently in bioengineering and could become an essential tool in the study of any physiological unity, regardless of its complexity. The main problem in modeling with finite elements simulation is to achieve an accurate reproduction of the anatomy and a perfect correlation of the different structures, in any region of the human body. Authors have developed a mixed technique, joining the use of a three-dimensional laser scanner Roland Picza captured together with computed tomography(CT) and 3D CT images, to achieve a perfect reproduction of the anatomy. Finite element(FE) simulation lets us know the biomechanical changes that take place after hipprostheses or osteosynthesis implantation and biological responses of bone to biomechanical changes. The simulation models are able to predict changes in bone stress distribution around the implant, so allowing preventing future pathologies. The development of a FE model of lumbar spine is another interesting application of the simulation. The model allows research on the lumbar spine, not only in physiological conditions but also simulating different load conditions, to assess the impact on biomechanics. Different degrees of disc degeneration can also be simulated to determine the impact on adjacent anatomical elements. Finally, FE models may be useful to test different fixation systems, i.e., pedicular screws, interbody devices or rigid fixations compared with the dynamic ones. We have also developed models of lumbar spine and hip joint to predict the occurrence of osteoporotic fractures, based on densitometric determinations and specific biomechanical models, including approaches from damage and fracture mechanics. FE simulations also allow us to predict the behavior of orthopedic splints applied to the correction of deformities, providing the recovering force-displacement and angle-moment curves that characterize the mechanical behavior of the splint in the overall range of movement. | Antonio Herrera Elena Ibarz José Cego?ino Antonio Lobo-Escolar Sergio Puértolas Enrique López Jesús Mateo Luis Gracia | 2012 | World Journal of Orthopedics2012，3，4： | 8 |
| 2 | 神经精神药理学治疗药物监测共识指南:2017版显示文摘治疗药物监测(Therapeutic Drug Monitoring,TDM)通过定量测定和解释血药浓度以优化药物治疗。TDM着眼于药代动力学的个体差异,使个体化药物治疗成为可能。在精神病学和神经病学领域中,有可能明显获益于TDM的主要患者群体包括少年儿童、孕妇、老年患者、智障患者、药物滥用者、涉法精神病患者、已知或怀疑药代动力学异常的患者以及合并躯体疾病影响药代动力学的患者。常规剂量下治疗无效,用药依从性难以判断,药物耐受性不佳,以及可能存在药代动力学方面的药物-药物相互作用等情况都是治疗药物监测的典型指征。然而,只有将TDM充分整合到临床治疗过程中,才能发挥其优化药物治疗的潜在优势。为了向临床医生和实验室提供有效的TDM信息,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了第一版《精神科治疗药物监测指南》。2011年进行了更新之后,现在再次更新。遵循新版指南,可能会改善神经精神药物治疗的效果,加快很多患者的康复,并降低医疗费用。 | C.Hiemke N.Bergemann H.W.Clement A.Conca J.Deckert K.Domschke G.Eckermann K.Egberts M.Gerlach C.Greiner G.Gründer E.Haen U.Havemann-Reinecke G.Hefner R.Helmer G.Janssen E.Jaquenoud G.Laux T.Messer R.M ssner M.J.Müller M.Paulzen B.Pfuhlmann P.Riederer A.Saria B.Schoppek G.Schoretsanitis M.Schwarz M.Silva Gracia B.Stegmann W.Steimer J.C.Stingl M.Uhr S.Ulrich S.Unterecker R.Waschgler G.Zernig G.Zurek P.Baumann 李文标(主译) 果伟(译) 贺静(译) 鲍爽(译) 路钊(译) 牛梦溪(译) 阮灿军(译) 臧彦楠(译) 王勇(译) 张玲(译) 刘辰庚(译) 李洁(译) 汤宜朗(审校) 王传跃(审校) 王刚(审校) | 2022 | 实用药物与临床2022，25，1： | 6 |
| 3 | Male osteoporosis: A review显示文摘Osteoporosis in men is a heterogeneous disease that has received little attention.However,one third of worldwide hip fractures occur in the male population.This problem is more prevalent in people over70 years of age.The etiology can be idiopathic or secondary to hypogonadism,vitamin D deficiency and inadequate calcium intake,hormonal treatments for prostate cancer,use of toxic and every disease or drug use that alters bone metabolism.Risk factors such as a previous history of fragility fracture should be assessed for the diagnosis.However,risk factors in men are very heterogeneous.There are significant differences in the pharmacological treatment of osteoporosis between men and women fundamentally due to the level of evidence in published trials supporting each treatment.New treatments will offer new therapeutic prospects.The goal of this work is a revision of the present status knowledge about male osteoporosis. | Antonio Herrera Antonio Lobo-Escolar Jesús Mateo Jorge Gil Elena Ibarz Luis Gracia | 2012 | World Journal of Orthopedics2012，3，12： | 5 |
| 4 | 神经精神药理学治疗药物监测共识指南:2017版显示文摘2.2剂量相关参考浓度范围对于TDM结果的解释,除了治疗参考浓度范围外还有另一个浓度范围,即所谓的剂量相关参考浓度范围。治疗参考浓度范围的应用是药效动力学问题,而剂量相关参考浓度范围的运用是药代动力学问题。后者比较的是测得的药物浓度与理论预期药物浓度范围。参照药代动力学研究,优先考虑没有合并用药或药物基因组异常的患者群(“正常”患者),在日维持剂量(Daily maintenance dose,D m)、给药间隔(Dosing interval,d i)、总清除率(Total clearance,CL)和生物利用度(Bioavailability,F)已知情况下,某种药物在某个“正常”患者体内的预期平均稳态浓度(Average steady-state concentration,C av)可通过下面的公式计算。 | C.Hiemke N.Bergemann H.W.Clement A.Conca J.Deckert K.Domschke G.Eckermann K.Egberts M.Gerlach C.Greiner G.Gründer E.Haen U.Havemann-Reinecke G.Hefner R.Helmer G.Janssen E.Jaquenoud G.Laux T.Messer R.M ssner M.JMüller M.Paulzen B.Pfuhlmann P.Riederer A.Saria B.Schoppek G.Schoretsanitis M.Schwarz M.Silva Gracia B.Stegmann W.Steimer J.C.Stingl M.Uhr S.Ulrich S.Unterecker R.Waschgler G.Zernig G.Zurek P.Baumann 李文标(译) 果伟(译) 贺静(译) 鲍爽(译) 路钊(译) 牛梦溪(译) 阮灿军(译) 臧彦楠(译) 王勇(译) 张玲(译) 刘辰庚(译) 李洁(译) 汤宜朗(译) 王传跃(译) 王刚(译) | 2022 | 实用药物与临床2022，25，2： | 4 |
| 5 | 妊娠早期异位妊娠的危险因素显示文摘Objective: To evaluate the association between ectopic pregnancy (EP) and clinical and historical factors among women presenting with pain and/or bleeding in early pregnancy. Design: Nested case-control study. Setting: University medical center. Patient(s): Women with symptomatic early pregnancies of unknown location presenting for care between January 1, 1990 and July 31, 1999. Intervention(s): None. Main Outcome Measure(s): Clinical and historical risk factors were compared between women with EP and women with ongoing intrauterine pregnancies or spontaneous abortions. Result(s): The following factors were associated with increased risk of EP: prior EP (odds ratio, 2.98 [95% confidence interval, 1.88- 4.73] for one prior EP and 16.04 [5.39- 47.72] for 2 or more), pelvic inflammatory disease history (1.5 [1.11- 2.05]), pain at presentation (1.42 [1.06- 1.92]),vaginal bleeding at presentation (1.42 [1.04- 1.93]), and hCG of 501- 2,000 mIU/mL (1.73 [1.24- 2.42]). Age younger than 25 years (0.59 [0.41- 0.85]) and a history of abortion were protective from EP (0.58 [0.38- 0.90]). Prior nontubal pelvic surgery, past intrauterine device use, prior cesarean section, and current cervical infection demonstrated no association with EP. Conclusion(s): Evaluation of women with a symptomatic early pregnancy confirms and refutes some of the classical risk factors for EP. Prior EP is a strong risk factor, whereas pelvic inflammatory disease has an unexpected weak association. Previous abortion was found to have a negative association, whereas nontubal surgery, cesarean section, and a history of or concomitant cervical infection have no association. Knowledge of historical and clinical factors associated with EP may aid in early diagnosis. | Barnhart K.T. Sammel M.D. Gracia C.R. 朱晓明 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，11： | 2 |
| 6 | Incident frailty and cognitive impairment by heart failure status in older patients with atrial fibrillation: the SAGE-AF study显示文摘Background Atrial fibrillation(AF) and heart failure(HF) frequently co-occur in older individuals. Among patients with AF, HF increases risks for stroke and death, but the associations between HF and incident cognition and physical impairment remain unknown. We aimed to examine the cross-sectional and prospective associations between HF, cognition, and frailty among older patients with AF. Methods The SAGE-AF(Systematic Assessment of Geriatric Elements in AF) study enrolled 1244 patients with AF(mean age 76 years, 48% women) from five practices in Massachusetts and Georgia. HF at baseline was identified from electronic health records using ICD-9/10 codes. At baseline and 1-year, frailty was assessed by Cardiovascular Health Survey score and cognition was assessed by the Montreal Cognitive Assessment. Results Patients with prevalent HF(n = 463, 37.2%) were older, less likely to be non-Hispanic white, had less education, and had greater cardiovascular comorbidity burden and higher CHA2 DS2 VASC and HAS-BLED scores than patients without HF(all P's < 0.01). In multivariable adjusted regression models, HF(present vs. absent) was associated with both prevalent frailty(adjusted odds ratio [a OR]: 2.38, 95% confidence interval [CI]: 1.64-3.46) and incident frailty at 1 year(a OR: 2.48, 95% CI: 1.37-4.51). HF was also independently associated with baseline cognitive impairment(a OR: 1.60, 95% CI: 1.22-2.11), but not with developing cognitive impairment at 1 year(a OR 1.04, 95%CI: 0.64-1.70). Conclusions Among ambulatory older patients with AF, the co-existence of HF identifies individuals with physical and cognitive impairments who are at higher short-term risk for becoming frail. Preventive strategies to this vulnerable subgroup merit consideration. | Wei-Jia WANG Darleen Lessard Jane Saczynski Robert J Goldberg Alan S.Go Tenes Paul Ely Gracia David D McManus | 2020 | Journal of Geriatric Cardiology2020，17，11： | 2 |
| 7 | Heavy metals in fish ( Solea vulgaris, Anguilla anguilla and Liza aurata ) from salt marshes on the southern Atlantic coast of Spain显示文摘 | José Usero Carmen Izquierdo José Morillo Ignacio Gracia | 2003 | Environment International2003，，7： | 2 |
| 8 | Desulfurization by adsorption with copper supported on zirconia显示文摘 | Baeza P Aguila G Gracia F | 2007 | Catalysis communications2007，30，2： | 1 |
| 9 | Enhancement of fault injection techniques based on the modification of VHDL code 显示文摘 | Baraza J C Gracia J Blanc S | 2008 | IEEE Transactions on Very Large Scale Integration (VLSI) Systems2008，16，6： | 1 |
| 10 | Assessing the need for reintubation; A prospective evaluatioin of unplanned endotracheal extubation显示文摘 | Razek T Gracias V Sullivan D | 2000 | J Trauma2000，48，3： | 1 |
| 11 | Optical and crystallization behavior of TiO2 and V/TiO2 thin films prepared by plasma and ion beam assisted methods显示文摘 | Holgado J P Contreras L | 2003 | Thin Solid films2003，429，12： | 1 |
| 12 | TiO2-catalysed ozonation of raw Ebro river water显示文摘 | Cortes S Sarasa J | 2000 | Water Res2000，34，： | 1 |
| 13 | DFT study of the reaction between VO+ and C2H6 显示文摘 | Gracia L Andres J Safont V S | 2004 | Organometallics2004，23，： | 1 |
| 14 | Prospective randomized trial comparing conventional laparoscopic colectomy with hand--assisted laparoscopic colectomy:pplicability,immediate clinical outcome,inflammatory response,and cost显示文摘 | Targarona EM Gracia E Garriga J | 2002 | Surg Endosc2002，16，2： | 1 |
| 15 | Alpha-amylase supplementation of broiler diets based on corn显示文摘 | Gracia M I Aranibar M J Lazaro R | 2003 | Poultry Science2003，82，： | 1 |
| 16 | Fast im- age blending using watersheds and graph cuts显示文摘 | Gracias N Mahoor M Negahdaripour S | 2009 | Image and Vision CompJting2009，27，5： | 1 |
| 17 | Financial liberalization, stock market volatility and outliers in emerging economies显示文摘 | Juncal Cunado Eizaguirre Javier Gomez Biscarri Fernando Perez de Gracia Hidalgo | 2009 | Applied Financial Economics2009，，10： | 1 |
| 18 | Trace metals in the bivalve mollusks Chamelea gallina from the Atlantic coast of southem Spain显示文摘 | Usero J Gonzalez-Regalado E Gracia I | 1996 | Marine Pollution Bulletin1996，32，： | 1 |
| 19 | Trace metal in the bivalve molluscs Ruditapes decussatus and Ruditapes phil- ippinarum from the Atlantic coast of southern Spain 显示文摘 | USERO J GONZALEZ- REGALADO E GRACIA I | 1997 | Environ Intern1997，23，3： | 1 |
| 20 | Do Oil Price Shocks Matter?Evidence for Some European Countries显示文摘 | Cunado Juncal & Perez de Gracia | 2003 | energy economics2003，，25： | 1 |
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