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| 1 | Predictors of disease severity in ulcerative colitis patients from Southwestern Ontario显示文摘AIM:To understand the demographic characteristics of patients in Southwestern Ontario,Canada with ulcerative colitis(UC)in order to predict disease severity. METHODS:Records from 1996 to 2001 were exam- ined to create a database of UC patients seen in the London Health Sciences Centre South Street Hospital Inflammatory Bowel Disease Clinic.To be included, patients'charts were required to have information of their disease presentation and a minimum of 5 years of follow-up.Charts were reviewed using standardized data collection forms.Disease severity was generated during the chart review process,and non-endoscopic Mayo Score criteria were collected into a composite. RESULTS:One hundred and two consecutive patients'data were entered into the database.Demographic analyses revealed that 51%of the patients were male, the mean age at diagnosis was 39 years,13.7%had a first degree relative with inflammatory bowel disease (IBD),61.8%were nonsmokers and 24.5%were ex-smokers.In 22.5%of patients the disease was limited to the rectum,in 21.6%disease was limited to the sigmoid colon,in 22.5%disease was limited to the left colon,and 32.4%of patients had pancolitis. Standard multiple regression analysis which regressed a composite of physician global assessment of disease severity,average number of bowel movements,and average amount of blood in bowel movements on year of diagnosis and age at time of diagnosis was significant,R 2=0.306,F(7,74)=4.66,P<0.01. Delay from symptoms to diagnosis of UC,gender, family history of IBD,smoking status and disease severity at the time of diagnosis didnot significantly predict the composite measure. CONCLUSION:UC severity is associated with younger age at diagnosis and year of diagnosis in a longitudinal cohort of UC patients,and may identify prognostic UC indicators. | Lee S Roth Nilesh Chande Terry Ponich Maya L Roth James Gregor | 2010 | World Journal of Gastroenterology2010，16，2： | 4 |
| 2 | The effects of 5-aza-2′-deoxycytidine (Decitabine) on the platelet count in patients with intermediate and high-risk myelodysplastic syndromes显示文摘 | Joan van den Bosch Michael Lübbert Gregor Verhoef P.W Wijermans | 2004 | Leukemia Research2004，，8： | 2 |
| 3 | Induction chemotherapy with gemcitabine and cisplatin in locally advanced stage Ⅲ non-small cell lung cancer:A phase Ⅱ Study显示文摘 | Crino L Betti M Gregore V | 1999 | Proc: Am Soc Clin Oneol1999，18，： | 1 |
| 4 | Endoplasmic ret/culum stress is reduced in tissues of obese subjects after weight loss 显示文摘 | Gregor MF Yang L Fabbrini E | 2009 | Diabetes2009，58，： | 1 |
| 5 | Frequency of represent-ative single nucleotide polymorphisms associated with inflam-matory bowel disease in the Czech Republic and Slovak Re-public 显示文摘 | Hosek J Bartosova L Gregor P | 2008 | Folia Biol (Praha)2008，54，3： | 1 |
| 6 | Exploring unique applications of kinetic analysis to movement in older adults显示文摘 | Wolf S L Gregor R J | 1999 | Journal of Applied Biomechanics1999，15，： | 1 |
| 7 | Improved embryoid induction and greeshoots regeneration from wheat anthers cultured in medium with maltose显示文摘 | Me Gregor L J Johissone G I E | 1990 | Plant Cell Rep1990，9，： | 1 |
| 8 | Aspect-oriented programming显示文摘 | GREGOR K JOHN L ANURAG M | 1997 | Springer-Verlag LNCS1997，1241，1： | 1 |
| 9 | Molecular characterization of a second mouse pancreatic polypeptide receptor and its inactivated human homologue显示文摘 | Gregor P Feng Y DeCarr L B | 1996 | J Biol Chem1996，271，27： | 1 |
| 10 | Electrical conductivity of polydivinylbenzene films 显示文摘 | Gregor L V | 1968 | Thin Solid Films1968，2，3： | 1 |
| 11 | Mismatches at the HLA-DR and HLA-B loci are risk faetors for acute rejection after lung transplantation 显示文摘 | Schulman L L Weinberg A D Me Gregor C | 1998 | Am J Respir Crit Care Med1998，157，10： | 1 |
| 12 | Techniques and complications of Tandem Heart ventricular assist device insertion during cardiac procedures显示文摘 | Gregoric ID Bruckner BA Jacob L | 2009 | ASAIO J2009，55，3： | 1 |
| 13 | Plant nutrient losses in runoff from conservation tillage corn显示文摘 | Mc Dowel L L Mc Gregor K C | 1984 | Soil and Tillage Res1984，4，： | 1 |
| 14 | Copper isotopes as monitors of redox processes in hydrothermal mineralization显示文摘 | Markl G Yann L Gregor S | 2006 | Geochim Cosmochim Acta2006，70，： | 1 |
| 15 | The role of adipocyte XBP1 in metabolic regulation during lactation显示文摘 | Gregor M F Misch E S Yang L | 2013 | Cell Rep2013，3，5： | 1 |
| 16 | Prevalence of ACE inhibitor use in diabetic hypertensives in hypertension speciality clinic: a guality assurance review显示文摘 | Gregor M Singer L Willian J | 2002 | AMJ Cardio2002，15，4： | 1 |
| 17 | Data Mining Stan dards Initiatives显示文摘 | Robert L Grossman Mark F Homick Gregor Meyer | 2002 | Communications of the ACM2002，45，8： | 1 |
| 18 | Irrigation scheduling methods for popcorn in the northern Great Plains 显示文摘 | Steele D D Gregor B L Shae J B | 1997 | Transactions of the ASAE1997，40，： | 1 |
| 19 | Arctic contaminants: sources, occurrence and pathways 显示文摘 | Barrie L A Gregor D Hargrave B | 1992 | Science of the Total Environment1992，122，12： | 1 |
| 20 | CD34-related coexpression of MDR1 and BCRP indicates a clinically resistant phenotype in patients with acute myeloid leukemia (AML) of older age显示文摘 | Marry M. Heuvel-Eibrink Bronno Holt Alan K. Burnett Wolfgang U. Knauf Martin F. Fey Gregor E. G. Verhoef Edo Vellenga Gert J. Ossenkoppele Bob L?wenberg Pieter Sonneveld | 2007 | Annals of Hematology2007，，5： | 1 |
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