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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Reliability of maintained,corrosion protected plates subjected to non-liner corrosion and compressive loads显示文摘 | Guedes Soares C Garbatov Y | 1999 | Marine Structures1999，12，6： | 2 |
| 3 | Optimization of Fenton's oxidation of chemical laboratory wastewaters using the response surface methodology 显示文摘 | Benatti C T Tavares C R G Guedes T A | 2006 | Journal of Environmental Management2006，80，： | 1 |
| 4 | Reliability of maintained ship hulls subjected to corrosion 显示文摘 | Guedes Soares C Garbatov Y | 1996 | Journalof Ship Research1996，40，3： | 1 |
| 5 | Effects of a Saccharomyces cerevisiae yeast on ruminal fermentation and fibre degradation of maize silages in cows显示文摘 | Guedes C M Gon alves D Rodrigues M A M | 2008 | Anim Feed Sci Tech2008，145，1： | 1 |
| 6 | Validation of an immunoperoxidase monolayer assay for total anti-Vac- cinia virus antibody titration 显示文摘 | Gerber P F Matos A C Guedes M I | 2012 | J Vet Diagn Invest2012，24，2： | 1 |
| 7 | Steepness and asymmetry of the largest waves in stormy sea states 显示文摘 | Guedes S C Cherneva Z Antao E M | 2004 | Ocean Engineering2004，，31： | 1 |
| 8 | Con-trols of heavy minerals and grain size in a holocene regressivebarrier(Ilha Comprida,southeastern Brazil)显示文摘 | Guedes C C F Giannini P C F Nascimento D R Jr | 2011 | Journal ofSouth American Earth Sciences2011，31，1： | 1 |
| 9 | Reliability of maintained ship hull girders subjected to corrosion and fatigue 显示文摘 | Guedes Soares C Garbatov Y | 1998 | Struetursl Ssfety1998，20，： | 1 |
| 10 | Simulation modelling of repairable multi-component deteriorating systems for on condition' maintenance optimization 显示文摘 | Barata J Soares C Guedes Marseguerra M Zio E | 2002 | Reliability Engineering and System Safety2002，76，3： | 1 |
| 11 | Allozyme variation among Brazilian and US populations of Rhyzopertha dominica resistant to insecticides显示文摘 | Guedes R N C Kambhampati S Dover B A | 1997 | Entomologia Experimentalis et Applicata1997，84，： | 1 |
| 12 | Analysis of Directional Wave Fileds Using X-band Navigation Radar显示文摘 | NIETO B J C GUEDES S C | 2000 | Journal of Coastal Engineering2000，40，1： | 1 |
| 13 | Photochemical processes and the environmental impact of petroleum spills 显示文摘 | Nicodem D E Fernandes M C Z Guedes C L B | 1997 | Biogeochemistry1997，39，： | 1 |
| 14 | Impact of socioeconomic and clinical factors on child oral health-related quality of life 显示文摘 | Piovesan C Antunes JL Guedes RS | 2010 | Qual Life Res2010，19，9： | 1 |
| 15 | Physical Characterization and Compression Tests of One Leaf Stone Masonry Walls 显示文摘 | Almeida C Guedes J P Ar~de A | 2012 | Construction and Building Materials2012，30，： | 1 |
| 16 | Cytotoxic evaluation of silicon nitride-based ceramics显示文摘 | Silva C Guedes e Higa O Z Bressiani J C | 2004 | Materials Science and Engineering2004，24，5： | 1 |
| 17 | Effects of metformin on the glycemic control,lipid profile,and arterial blood pressure of type 2 diabetic patients with metabolic syndrome already on insulin显示文摘 | Mourao Junior C A Sa J R Guedes O M | 2006 | Braz J Med Biol Res2006，39，4： | 1 |
| 18 | Statistical analysis of still-water load effects on ship structures 显示文摘 | Guedes Soares C Moan T | 1988 | Transactions Society of Naval Architects and Marine Engineers1988，96，： | 1 |
| 19 | Nucleation and crystal growth in commercial LAS compositions显示文摘 | Guedes M Ferro A C Ferreira J M F | 2001 | Journal of the E(ur)opean Ceramic Society2001，，21： | 1 |
| 20 | Systematic study of a brazilian intermediate crude oil 显示文摘 | Nicodem D E Guedes C L B Correa R J Photochemistry of petroleum I | 1997 | MarChem1997，63，： | 1 |
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