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| 1 | GRADE指南:Ⅷ.证据质量评价--间接性显示文摘直接证据来自直接比较我们关注的干预措施用于我们关注的患者人群,并测量患者重要结局的研究。间接证据可由以下4种方式之一产生。第一,患者可能与我们关注的患者不同(适用性一词常用于这类间接性)。第二,所检验的干预措施可能与我们关注的干预措施不同。有关患者和干预措施间接性的决策取决于对生物或社会因素差异是否大到可能使效应尺度出现预期的较大差异的考虑。第三,结果可能有别于最初设定的结局指标——如替代结果本身不重要,但测量之是基于替代结果的变化反映患者重要结局变化这一假设。第四类间接性在概念上与前三类不同,发生于临床医生必须在未经直接比较的两种干预措施间做出选择时。这种情况下比较治疗方案需要特定的统计方法,并根据患者人群、联合干预措施、结局测量指标及备选干预措施试验方法的差异程度,将证据级别降低1或2级。 | Gordon Guyatt Andrew D.Oxman Regina Kunz James Woodcock Jan Brozek Mark Helfand Pablo Alonso-Coello Yngve Falck-Ytter Roman Jaeschke Gunn Vist Elie A.Akl Piet N Post Susan Norris Joerg Meerpohl Mona Nasser 代表GRADE工作组 李幼平 杨晓妍 李鸿浩 | 2011 | 中国循证医学杂志2011，11，12： | 30 |
| 2 | In stent restenosis: more metal and more symmetry required 显示文摘 | Gunn J Malik N Shepherd L | 1997 | Heart1997，7，： | 2 |
| 3 | Chitosan-based hydrogels for controlled, localized drug delivery 显示文摘 | Blaattarai N Gunn J Zhang M | 2010 | Adv Drug Deliv Rev2010，62，1： | 1 |
| 4 | Limiting the Persistence of a Chromosome Break Diminishes Its Mutagenic Potential显示文摘 | Bennardo N Gunn A Cheng A | 2009 | PLoS Genet2009，5，10： | 1 |
| 5 | In-stent restenosis: more metal and more symmetry required显示文摘 | Malik N Holt CM | 1997 | Heart1997，77，1： | 1 |
| 6 | The development of menstrual - related beliefs and behaviors during Early adolescence 显示文摘 | BROOKS- GUNN J RUBLE D N | 1982 | Child Development1982，53，： | 1 |
| 7 | Identi- fication of interferon-stimulated gene 15 as an antiviral mole- cule during Sindhis virus infection in vivo显示文摘 | Lenschow D J Giannakopoulos N V Gunn L J | 2005 | J Virol2005，79，13： | 1 |
| 8 | Direct validation of annual increments in the otoliths of juvenile southern bluefin tuna, Thunnus maccoyii, by means of a largescale mark-recapture experiment with strontium chloride 显示文摘 | Clear N P Gunn J S Rees A J | 2000 | Fish Bull2000，98，1： | 1 |
| 9 | PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release显示文摘 | BHATTARAI N RAMAY HR GUNN J | 2005 | J Control Realease2005，103，3： | 1 |
| 10 | Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim,Noxa and Mcl-1显示文摘 | HUNTINGTON N D PUTHALAKATH H GUNN P | 2007 | Nat Immunol2007，8，8： | 1 |
| 11 | The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances gemcitabine-induced cell death in pancreatic cancer显示文摘 | ARNOLD N B ARKUFL N GUNN J | 2007 | Clin Cancer Res2007，13，1： | 1 |
| 12 | Condensation of 'Composite Bosons' in a Rotating BEC显示文摘 | Wilkin N K Gunn J M F | 2000 | Phys Rev Lett2000，84，： | 1 |
| 13 | In stent restenosis:More metal and more symmetry required显示文摘 | Gunn J Malik N Shepherd L | 1997 | Heart1997，7，： | 1 |
| 14 | Oscillations of tillage implements显示文摘 | GUNN J T TRAMONTINI V N | 1995 | Agricultural Engineering1995，36，11： | 1 |
| 15 | 显示文摘 | Bhattarai N Ramay H R Gunn J | 2005 | Journal of Controlled Release2005，103，3： | 1 |
| 16 | Predictors of PEG dependence after IMRT ± chemotherapy for oropharyngeal cancer显示文摘 | Sanguineti G Rao N Gunn B | 2013 | Radiother Oncol2013，107，： | 1 |
| 17 | Quantum Phases of Vortices in Rotating Bose-Einstein Condensates显示文摘 | Cooper N R Wilkin N K Gunn J M F | 2001 | Phys Rev Lett2001，87，12： | 1 |
| 18 | Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo 显示文摘 | Lenschow D J Giannakopoulos N V Gunn L J | 2005 | J Virol2005，79，13： | 1 |
| 19 | PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release 显示文摘 | Bhattarai N Ramay H R Gunn J | 2005 | Journal of Controlled Release2005，103，3： | 1 |
| 20 | The menstrual at- Litude questionnaire 显示文摘 | BROOKS - GUNN J RUBLE D N | 1980 | Psychosomatic Medicine1980，42，： | 1 |
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