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| 1 | Arrhythmogenic mechanisms in ryanodine receptor channelopathies显示文摘Ryanodine receptors(Ry Rs) are the calcium release channels of sarcoplasmic reticulum(SR) that provide the majority of calcium ions(Ca2+) necessary to induce contraction of cardiac and skeletal muscle cells.In their intracellular environment,Ry R channels are regulated by a variety of cytosolic and luminal factors so that their output signal(Ca2+) induces finely-graded cell contraction without igniting cellular processes that may lead to aberrant electrical activity(ventricular arrhythmias) or cellular remodeling.The importance of Ry R dysfunction has been recently highlighted with the demonstration that point mutations in RYR2,the gene encoding for the cardiac isoform of the Ry R(Ry R2),are associated with catecholaminergic polymorphic ventricular tachycardia(CPVT),an arrhythmogenic syndrome characterized by the development of adrenergically-mediated ventricular tachycardia in individuals with an apparently normal heart.Here we summarize the state of the field in regards to the main arrhythmogenic mechanisms triggered by Ry R2 channels harboring mutations linked to CPVT.Most CPVT mutations characterized to date endow Ry R2 channels with a gain of function,resulting in hyperactive channels that release Ca2+ spontaneously,especially during diastole.The spontaneous Ca2+ release is extruded by the electrogenic Na+/Ca2+ exchanger,which depolarizes the external membrane(delayed afterdepolarization or DAD) and may trigger untimely action potentials.However,a rare set of CPVT mutations yield Ry R2 channels that are intrinsically hypo-active and hypo-responsive to stimuli,and it is unclear whether these channels release Ca2+ spontaneously during diastole.We discuss novel cellular mechanisms that appear more suitable to explain ventricular arrhythmias due to Ry R2 loss-of-function mutations. | ZHAO Yan-Ting VALDIVIA Carmen R. GURROLA Georgina B. HERNNDEZ Jonathan J. VALDIVIA Héctor H. | 2015 | Science China(Life Sciences)2015，58，1： | 14 |
| 2 | Impact and Solutions of Seawater Heterogeneity on Wide-Angle Tomographic Inversion of Crustal Velocities in Deep Marine Environments—Numerical Studies显示文摘The seawater column is typically taken as a homogeneous velocity layer in wide-angle crustal seismic surveys in marine environments. However, heterogeneities in salinity and temperature throughout the seawater layer result insignificant lateral variations in its seismic velocity, especially in deep marine environments. Failure to compensate for these velocity inhomogeneities will introduce significant artifacts in constructing crustal velocity models using seismic tomography. In this study, we conduct numerical experiments to investigate the impact of heterogeneous seismic velocities in seawater on tomographic inversion for crustal velocity models. Experiments that include lateral variation in seawater velocity demonstrated that the modeled crustal velocities were contaminated by artifacts from tomographic inversions when assuming a homogeneous water layer. To suppress such artifacts, we propose two strategies:(1) simultaneous inversion of water velocities and the crustal velocities;(2) layer-stripping inversion during which to first invert for seawater velocity and then correct the travel times before inverting for crustal velocities. The layer-stripping inversion significantly improves the modeling of variation in seawater velocity when preformed with seismic sensors deployed on the ocean bottom and in the water column. Such strategies improve crustal modeling via wide-angle seismic surveys in deep-marine environment. | Zhihui Zou Hua-Wei Zhou Harold Gurrola Aifei Bian Zhonglai Huang Jianzhong Zhang | 2018 | Journal of Earth Science2018，29，6： | 3 |
| 3 | Geomorphic criteria to determine direction of lateral propagation of reverse faultingand folding显示文摘 | Keller E A Gurrola L Tierney T E | 1999 | Geology1999，27，： | 1 |
| 4 | Importancia de los as- pectos hidrol6gicos en la planeaci6n urbana 显示文摘 | Gleason Espindola Jose Arturo Acosta Gurrola Mireya Peregrina Lucano Alejandro Aaron | 2010 | Revista de Difusi6n Cient~ca2010，5，1： | 1 |
| 5 | Mutations of KCNJ10 together with mutations of SLC26A4 cause digenic nonsyndromic hearing loss associated with enlarged vestibular aqueduct syndrome显示文摘 | Yang T Gurrola JG Wu H | 2009 | Am J Hum Genet2009，84，： | 1 |
| 6 | A Large Number of Novel Ergtoxin-Like Genes and ERG K+-Channels Blocking Peptides from Scorpions of the Genus Centruroides显示文摘 | Corona M Gurrola G B Possani L D | 2002 | FEBS Lett2002，532，： | 1 |
| 7 | Identification of adenoid biofilms in chronic rhinosinusitis 显示文摘 | Zuliani G Carron M Gurrola J | 2006 | Int J Pediatr Otorhinolaryngol2006，70，： | 1 |
| 8 | Ha- drurin, a new anti - microbial peptide from the venom of the scorpion Hadrurus aztecus 显示文摘 | Torres - Larios A Gurrola G B Zamudio F Z | 2000 | Eur J Bioehem2000，267，16： | 1 |
| 9 | Two similar peptides from the venom of the scorpion pandinus imperator, one highly effective blocker and the other inactive on K+ channels显示文摘 | Olamendi PT Gomez LF Gurrola GB | | 0，，： | 1 |
| 10 | Structure and Function of Scorpion Toxins Affecting K+-Channels显示文摘 | Possani L D Selisko B Gurrola G B | 1999 | Perspectives in Drug Discovery and Design1999，1516，： | 1 |
| 11 | Three-dimensional Location of the Imperatoxin a Binding Site on the Ryanodine Receptor 显示文摘 | Samso M Trujillo R Gurrola G B | 1999 | J Cell Biol1999，146，2： | 1 |
| 12 | Mutations of KCNJ 10 together with mutations of SLC26A4 cause digenic nonsyndromic hearing loss associated with enlarged vestibular aqueduct syndrome显示文摘 | YANG T GURROLA J WU H | 2009 | Am J Hum Genet2009，84，： | 1 |
| 13 | Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus 显示文摘 | Torres-Larios A Gurrola G B Zamudio F Z | 2000 | Eur J Biochem2000，267，16： | 1 |
| 14 | Identification of adenoid bio films in chronic rhinosinusitis显示文摘 | Zuliani G Carron M Gurrola J | 2006 | Int J Pediater Otorhinolaryngol2006，70，： | 1 |
| 15 | Two similar peptides from the venom of the scorpion pandinus imperator,one highly effective blocker and the other inactive on K+channels显示文摘 | Olamendi PT Gomez LF Gurrola GB | 1998 | Toxicon1998，36，5： | 1 |
| 16 | The epsilon4 allele of apolipoprotein E gene is a potential risk factor for the severity of macular edema in type 2 diabetic Mexican patients显示文摘 | Santos A Salguero ML Gurrola C | 2002 | Ophthalmic Genet2002，23，： | 1 |
| 17 | Scorpion venom components that affection - channels function 显示文摘 | Quintero - Hernandez V Jimanez - Vargas JM Gurrola GB | 2013 | Toxicon2013，76，： | 1 |
| 18 | P16 a immunohistochemistry improves the reproducibility of the histological diagnosis of cervical intraepithelial neoplasia in cone biopsies显示文摘 | Gurrola Diaz CM Suarez Rincon AE Vazquez Camacho G | 2008 | Gynecol Oncol2008，111，1： | 1 |
| 19 | Diathermic loop treatment of subclinical cervical infection by human papilloma virus(HPV) o Short term effectiveness显示文摘 | Milla Vilieda RH Gurrola Medrano T | 1995 | Ginecol Obstet Mex1995，63，： | 1 |
| 20 | Identification of adenoid bio- films in chronic rhinosinusitis 显示文摘 | Zuliani G Carron M Gurrola J | 2006 | Int J Pediatr Otorhinolaryngol2006，70，9： | 1 |
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