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		题名	作者	年代	出处	被引量
	1	LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer显示文摘Objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma(NPC).Methods DCs were derived from peripheral blood monocytes of patients with NPC.We prepared LMP2-DCs infected by recombinant adenovirus vector expressing LMP2(rAd-LMP2).NPC patients were immunized with 2×105 LMP2-DCs by intradermal injection at week 0 and after the second and fourth weeks.Specific responses to LMP2 were detected by enzyme-linked immunospot(ELISPOT)assay at week 0 and at the fifth and eighth weeks.Local clinicians performed the follow-up and tracking of patients.Results We demonstrated that DCs derived from monocytes displayed typical DC morphologies;the expression of LMP2 in the LMP2-DCs vaccine was confirmed by immunocytochemical assay.Twenty-nine patients with NPC were enrolled in this clinical trial.The LMP2-DCs vaccine was well tolerated in all of the patients.Boosted responses to LMP2 peptide sub-pools were observed in 18 of the 29 patients with NPC.The follow-up data of 29 immunized patients from April,2010 to April 2015 indicated a five-year survival rate of 94.4%in responders and 45.5%in non-responders.Conclusion In this pilot study,we demonstrated that the LMP2-DCs vaccine is safe and effective in patients with NPC.Specific CTLs responses to LMP2 play a certain role in controlling and preventing the recurrence and metastasis of NPC,which warrants further clinical testing.	ZENG Yi SI Yong Feng LAN Gui Ping WANG Zhan ZHOU Ling TANG Min Zhong SJ O`Brien LAN Jiao ZHOU Xiang Yang WANG Yong Li TANG Juan ZHOU Zhi Xiang DU Hai Jun LIN Hui	2020	Biomedical and Environmental Sciences2020，33，11：	2
	2	Canonical realization of Chua's circuit family显示文摘	Chua L O Gui N L	1990	IEEE Transction on Circuit and System1990，37，7：	1
	3	Identification of the SAAT gene involved in strawberry flavor biogenesis by use of DNA microarrays显示文摘	AHARONI A KEIZER L C BOUWMEESTER H J SUN Z ALVAREZ-HUERTA M VERHOEVEN H A BLAAS J Van HOUWELINGEN A M DE VOS R C VAN DER VOET H JANSEN R C GUIS M MOL J DAVIS R W SCHENA M VAN TUNEN A J O'CONNELL A P	2000	Plant Cell2000，12，5：	1
	4	Identification of the SAAT gene in- volved in strawberry flavor biogenesis by use of DNA microarrays显示文摘	AHARONI A KEIZER L C P BOUWMEESTER H J SUN Z K ALVAREZ-HUERTA M VERHOEVEN H A BLAAS J VAN HOUWELINGEN A M M L DE VOS R C H VAN DER VOET H JANSEN R C GUIS M MOL J DAVIS R W SCHENA M VAN TUNEN A J O' CONNELL A P	2000	The Plant Cell2000，12，5：	1
	5	A corn prehensive electric field analysis of a multifunc tional elelctrospinning platform 显示文摘	JENTZSCH E GUI O OZNERGIZ E	2013	Journal of Electrostatics2013，71，3：	1
	6	Inappropriate liver transplantation in a child with Alpers-Huttenlocher syndrome misdiagnosed as valproate-induced acute liver failure显示文摘	Delarue A Paut O Guys JM Montfort MF Lethel V Roquelaure B	2000	Pediatr Transplant2000，4，1：	1
	7	Team Human Capital and Worker Mobility 显示文摘	Chillemi O Gui B	1997	Journal of Labor Economics1997，15，4：	1
	8	Prevalence of venous thromboembolism in patients with secondary polycythcmia 显示文摘	Nadeem O Gui J Ornstein DL	2013	Clin Appl Thromb Hemost2013，19，4：	1
	9	Prevalence of venous thromboembolism in patients with secondary polycythemia显示文摘	Nadeem O Gui J Ornstein DL	2013	Clin Appl Thromb Hemost2013，19，：	1
	10	Multiresolution texture based adaptive clustering algorithm for breast, lesion segmen- tation 显示文摘	BOUKERROUI D BASSET O GUI~RIN N	1998	Eur J Ultrasound1998，8，2：	1
	11	Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia 显示文摘	Hochhaus A O'Brien S G Gui\|hot F	2009	Leukemia2009，23，6：	1
	12	Genomic sequence of man- darin fish rhabdovirus with an unusual small non-transcrip- tional ORF显示文摘	Tao J J Zhou O Z Gui J F	2008	Virus Res2008，132，：	1
	13	Implementing extended pro- ducer responsibility legislation 显示文摘	GUI L ATASU A ERGUN O	2013	Journal of Industrial Ecology2013，17，2：	1

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