|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. | Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames | 2014 | World Journal of Diabetes2014，5，2： | 13 |
| 2 | Nonlinear resonance ultrasound spectroscopy(NRUS) applied to damage assessment in bone显示文摘 | MULLER M SUTIN A GUYER R | 2005 | The Journal of the Acoustical Society of America2005，118，6： | 1 |
| 3 | Nonlinear mesoscopical elasticity: evidence for a new class of material显示文摘 | Guyer R A Johnson P A | 1999 | Physics Today1999，52，14： | 1 |
| 4 | Temperature pulses in dielectric solids显示文摘 | Ackerman C C Guyer R A | 1968 | Ann Phys1968，50，1： | 1 |
| 5 | Near-infrared hyperspectml reflec- tance imaging for detection of bruises on pickling cucumbers显示文摘 | ARIANA D P LU R GUYER D E | 2006 | Com- puters and Electronics in Agriculture2006，53，1： | 1 |
| 6 | Equation of state and wave propagation in hysteretic nonlinear elastic material显示文摘 | MCCALL K R GUYER RA | 1994 | Journal of Geophysical Research1994，99，23： | 1 |
| 7 | Intradis- eal pressur measurements above an instrumented fusiona eadavefic study显示文摘 | WEINHOFFER S L GUYER R D HERBERT M | 1995 | Spine1995，20，5： | 1 |
| 8 | The NIH human microbiome project显示文摘 | NIH HMP Working Group Peterson J Garges S Giovanni M McInnes P Wang L Schloss JA Bonazzi V McEwen JE Wetterstrand KA Deal C Baker CC Di Francesco V Howcroft TK Karp RW Lunsford RD Wellington CR Belachew T Wright M Giblin C David H Mills M Salomon R Mullins C Akolkar B Begg L Davis C Grandison L Humble M Khalsa J Little AR Peavy H Pontzer C Portnoy M Sayre MH Starke-Reed P Zakhari S Read J Watson B Guyer M | 2009 | Genome Res2009，19，12： | 1 |
| 9 | Equation of state and wave propagation in hysteretic nonlinear elastic materials显示文摘 | McCall K R Guyer R A | 1994 | Journal of Geophysical Research1994，99，23： | 1 |
| 10 | Determination of firmnessand sugar content of apples using near-infrared diffuse reflectance显示文摘 | LU R GUYER D E BEAUDRY R M | 2007 | Journal of Texture Studies2007，31，6： | 1 |
| 11 | Equation of state and wave propagation in hysteretic nonlinear elastic material显示文摘 | MCCALL K R GUYER R A | 1994 | Journal of Geophysical Research1994，99，23： | 1 |
| 12 | Near-infrared hyperspectral reflectance imaging for detection of bruises on pickling cucumbers显示文摘 | Ariana D P Lu R Guyer D E | 2006 | Computers and Electronics in Agriculture2006，53，： | 1 |
| 13 | Hystere- sis, discrete memory, and nonlinear wave propagation in rock: a new paradigm 显示文摘 | GUYER R A MCCALL K R BOITNOTI' G N | 1995 | Phys Rev Lett1995，74，17： | 1 |
| 14 | The Wiltse pedicle screw fixation system显示文摘 | Guyer D W Wiltse L L Peek R D | 1988 | Orthopedics1988，11，： | 1 |
| 15 | The choroids:structural considerations显示文摘 | GUYER D R SCHACHAT A D GREEN W R | 1994 | Retina1994，1，： | 1 |
| 16 | Discitis after discography显示文摘 | GUYER R D COLLIER R STITH W J | 1988 | Spine1988，13，12： | 1 |
| 17 | Hysteresis and the dynamic elasticity of consolidated granular materials 显示文摘 | GUYER R A TENCATE J JOHNSON P | 1999 | Physical Review Letters1999，82，16： | 1 |
| 18 | Prospective, randomized, mnlticenter studyof cervical arthroplasty: 269 patients fromtheKineflex/C artificial disc investigational device exemption study with a minimum 2-year follow-up 显示文摘 | Coric D Nunley P D Guyer R D | 2011 | J Neurosurg Spine2011，15，4： | 1 |
| 19 | Hyperspectral reflectance imaging for detection of bruises on pickling cucumbers显示文摘 | Ariana D Lu R Guyer D E | 2006 | Computers and Electronics in Agriculture2006，53，1： | 1 |
| 20 | Near-infrared hyperspectral reflectance imaging for detection of bruises on pickling cucumbers显示文摘 | Ariana D P Lu R F Guyer D E | 2006 | Computers and Electronics in Agriculture2006，53，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员