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| 1 | Immunohistochemical analysis of p53,cyclinD1,RB1,c-fos and N-ras gene expression in hepatocellular carcinoma in Iran显示文摘AIM: To study the effect of some genes especially those involved in cell cycle regulation on hepatocellular carcinoma. METHODS: Paraffin-embedded tissue samples of 25 patients (18 males and 7 females) with hepatocellular carcinoma were collected from 22 pathology centers in Tehran during 2000-2001, and stained using immunohistochemistry method (avidin-biotin-peroxidase) for detection of p53, cyclinD1, RB1, c-fos and N-ras proteins. RESULTS: Six (24%), 5 (20%), 12 (48%) and 2 samples (8%) were positive for p53, cyclinD1, C-fos and N-ras expression, respectively. Twenty-two (88%) samples had alterations in the G1 cell-cycle checkpoint protein expression (RB1 or cyclinD1). P53 positive samples showed a higher (9 times) risk of being positive for RB1 protein than p53 negative samples. Loss of expression of RB1 in association with p53 over-expression was observed in 4 (66.7%) of 6 samples. Loss of expression of RB1 was seen in all cyclinD1 positive, 20 (90.9%) N-ras negative, and 11 (50%) C-fos positive samples, respectively. CyclinD1 positive samples showed a higher (2.85 and 4.75 times) risk of being positive for c-fos and N-ras expression than cyclinD1 negative samples. CONCLUSION: The expression of p53, RB1 and c-fos genes appears to have a key role in the pathogenesis of hepatocellular carcinoma in Iran. Simultaneous overexpression of these genes is significantly associated with their loss of expression during development of hepatocellular carcinoma. | SJ Moghaddam EN Haghighi S Samiee N Shahid AR Keramati S Dadgar MR Zali | 2007 | World Journal of Gastroenterology2007，13，4： | 73 |
| 2 | 页岩气产量数据分析方法及产能预测显示文摘基于页岩气井线性非稳态流动特点,运用双重孔隙线性瞬态流典型曲线分析Eagle Ford页岩气藏一口多级压裂水平井产量数据,并进行储量评价。根据产量与时间双对数曲线关系,将该气井生产分为表皮效应、线性流动、边界效应3个流动阶段;运用基质线性流动模型计算该气藏基质渗透率,利用数值模型对计算结果进行验证;根据边界效应时间点求取该井体积压裂范围游离气储量,在此基础上进行产能预测,并研究吸附气解吸对气井产量的影响。结果表明:该井体积压裂范围游离气储量与裂缝模拟结果符合度超过85%;解吸气对页岩气井产量贡献取决于平均地层压力与吸附曲线形态;解吸气对该页岩气藏开发早中期的影响可忽略,对开发后期产量的影响很大,气体解吸能增加总采出量30%以上。 | 徐兵祥 李相方 HAGHIGHI Manouchehr 张磊 张保瑞 王威 | 2013 | 中国石油大学学报(自然科学版)2013，37，3： | 37 |
| 3 | 裂缝性页岩气藏水平井产能预测模型显示文摘基于页岩气藏线性、非稳态流动特点,考虑未压裂区双重介质特点及其对产气的贡献,建立页岩气多级压裂水平井渗流模型并求得定压条件下Laplace空间解。数值模型验证表明解析解与数值解吻合度高,在此基础上推导新的页岩气双孔瞬态产量典型曲线,补充和发展原有页岩气SRV模型典型曲线,并进行参数敏感分析,将新建典型曲线与SRV模型、Brohi模型典型曲线进行对比。结果表明:新典型曲线流动阶段表现为线性流与过渡流交替,较Brohi单孔外区模型典型曲线更复杂;气藏尺寸、窜流系数、内外区裂缝渗透率比对典型曲线影响很大,而储容比的影响不明显;未压裂区天然裂缝对气井产量有积极作用,对页岩气藏进行产能预测时不可忽略。 | 徐兵祥 李相方 HAGHIGHI Manouchehr 张磊 龚崛 葛涛涛 | 2013 | 中国石油大学学报(自然科学版)2013，37，6： | 14 |
| 4 | 口腔护理对危重症患者口腔健康状况和呼吸机相关性肺炎预防的影响显示文摘目的:本研究的目的是明确口腔护理措施对重症监护室患者口腔健康状况和呼吸机相关性肺炎发生率的影响。方法:本临床实验纳入2015-2016年间的100名患者,随机分为对照组(接受护士的口腔护理)和干预组(接受研究人员的系统口腔护理)。根据干预组患者的口腔健康状况,按照Beck口腔护理频次评价表(BOAS)确定需要接受口腔护理的频次。每次护理均包括调整气管内套管压力、用牙膏刷牙、使用抗菌药和嘴唇保湿。口腔检查采用BOAS和口腔黏膜菌斑量表评分,肺炎监测采用临床肺部感染评分。结果:第1~5天,两组患者的BOAS评分有统计学差异(P<0.001);第3~5天,两组患者的口腔黏膜菌斑评分有统计学差异(P<0.001);第3天和第5天,对照组肺炎发生率分别为10%(5例)和14%(7例),干预组肺炎发生率分别为4%(2例)和10%(5例),Fisher检验无统计学差异(P=0.538),但与对照组相比,干预组肺炎的发生率降低。结论:与传统的口腔护理措施比较,系统口腔护理虽然没有显著降低危重症患者呼吸机相关性肺炎的发生率,但显著改善了其口腔健康状况和口腔黏膜菌斑评分。 | Abdullah Haghighi Vida Shafipour Masoumeh Bagheri-Nesami Afshin Gholipour Baradari Jamshid Yazdani Charati | 2017 | 中国护理管理2017，17，3： | 14 |
| 5 | Adsorption of benzene and toluene from waste gas using activated carbon activated by ZnCl2显示文摘有高表面区域的一系列激活的碳与 ZnCl 用化学激活从核桃壳被准备 < 潜水艇 class= “ a-plus-plus ” > 2 。在这研究,碳化阶段在 500 点被执行 ??? | Leila KARIMNEZHAD | 2014 | Frontiers of Environmental Science & Engineering2014，8，6： | 13 |
| 6 | Challenging loop-mediated isothermal amplification(LAMP) technique for molecular detection of Toxoplasma gondii显示文摘Objective:To compare analytical sensitivity and specificity of a newly described DNA amplification technique.LAMP and nested PCR assay targeting the RE and Bl genes for the detection of Toxoplasma gondii(T.gondii) DNA.Methods:The analytical sensitivity of LAMP and ncstcd-PCR was obtained against 10-fold serial dilutions of T.gondii DNA ranging from 1 ng to 0.01 fg.DNA samples of other parasites and human chromosomal DNA were used to determine the specificity of molecular assays.Results:After testing LAMP and nesled-PCR in duplicate,the detection limit of RE-LAMP.B1-LAMP,RE-nested PCR and B1-nested PCR assays was one fg.100 fg,1 pg and 10 pg of T.gondii DNA respectively.All the LAMP assays and nested PCRs were 100% specific.The RE-LAMP assay revealed the most sensitivity for the detection of T.gondii DNA.Conclusions:The obtained results demonstrate that the LAMP technique has a greater sensitivity for detection of T.gondii.Furthermore,these findings indicate that primers based on the RE are more suitable than those based on the B1 gene.However,the B1-LAMP assay has potential as a diagnostic tool for detection of T.gondii. | Shirzad Fallahi Zahra Arab Mazar Mehrdad Ghasemian Ali Haghighi | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，5： | 6 |
| 7 | Fuzzy expert system for diagnosing diabetic neuropathy显示文摘AIM To design a fuzzy expert system to help detect and diagnose the severity of diabetic neuropathy. METHODS The research was completed in 2014 and consisted of two main phases. In the first phase, the diagnostic parameters were determined based on the literature review and by investigating specialists' perspectives(n= 8). In the second phase, 244 medical records related to the patients who were visited in an endocrinology and metabolism research centre during the first six months of 2014 and were primarily diagnosed with diabetic neuropathy, were used to test the sensitivity, specificity, and accuracy of the fuzzy expert system.RESULTS The final diagnostic parameters included the duration of diabetes, the score of a symptom examination based on the Michigan questionnaire, the score of a sign examination based on the Michigan questionnaire, the glycolysis haemoglobin level, fasting blood sugar, blood creatinine, and albuminuria. The output variable was the severity of diabetic neuropathy which was shown as a number between zero and 10, had been divided into four categories: absence of the disease,(the degree of severity) mild, moderate, and severe. The interface of the system was designed by ASP.Net(Active Server Pages Network Enabled Technology) and the system function was tested in terms of sensitivity(true positive rate)(89%), specificity(true negative rate)(98%), and accuracy(a proportion of true results, both positive and negative)(93%).CONCLUSION The system designed in this study can help specialistsand general practitioners to diagnose the disease more quickly to improve the quality of care for patients. | Meysam Rahmani Katigari Haleh Ayatollahi Mojtaba Malek Mehran Kamkar Haghighi | 2017 | World Journal of Diabetes2017，8，2： | 5 |
| 8 | A green method for the synthesis of bis-indolylmethanes and 3,3'-indolyloxindole derivatives using cellulose sulfuric acid under solvent-free conditions显示文摘A highly efficient green protocol for the preparation of bis-indolylmethanes,bis-2-methylindolylmethanes,bis-1-methylindolylmethanes and 3,3'-diindolyloxindole derivatives from the reaction of indoles with various aldehydes and ketones in the presence of cellulose sulfuric acid under solvent-free conditions is reported.The significant features of this procedure are high yields of the products,mild reaction,solvent-free condition and non-toxicity of the catalyst. | Heshmatollah Alinezhad Asefeh Hagh Haghighi Fatemeh Salehian | 2010 | Chinese Chemical Letters2010，21，2： | 5 |
| 9 | Synthesis, physicochemical characterizations and catalytic performance of Pd/carbon-zeolite and Pd/carbon-Ce02 nanocatalysts used for total oxidation of xylene at low temperatures显示文摘 | Zeinab JAMALZADEH | 2013 | Frontiers of Environmental Science & Engineering2013，7，3： | 5 |
| 10 | DEA/TEAOH templated synthesis and characterization of nanostructured NiAPSO-34 particles:Effect of single and mixed templates on catalyst properties and performance in the methanol to olefin reaction显示文摘A nanostructured NiAPSO-34 catalyst was hydrothermally synthesized and the effect of the template(diethylamine(DEA),tetraethylammonium hydroxide(TEAOH) and DEA/TEAOH) on the physicochemical properties and catalytic performance in the methanol to olefin(MTO) reaction was investigated.The samples were characterized by X-ray diffraction,field emission scanning electron microscopy(FESEM),particle size distribution analysis,energy-dispersive X-ray spectroscopy,Brunauer-Emmett-Teller analysis and Fourier transform infrared spectroscopy.The X-ray diffraction patterns indicated a higher crystallinity and larger crystallite size for the catalyst synthesized using the DEA template.The FESEM results indicated that the nature of the template could affect the morphology of the nanostructured NiAPSO-34 catalyst because of its effect on the rate of crystal growth.The catalytic performance of the samples was studied in the MTO reaction at atmospheric pressure and a space velocity of 4200 cm^3/(g h^(-1))in a fixed bed reactor.The stability and activity of the NiAPSO-34 catalyst were improved using the DEA template because of its higher crystallinity,surface area and the greater extent of Ni incorporation into its framework.The possible stages of synthesis and the reaction mechanism for the MTO process over NiAPSO-34 are discussed in detail. | Parisa Sadeghpour Mohammad Haghighi | 2015 | Particuology2015，13，2： | 3 |
| 11 | Review and assessment of different perspectives of vehicle-pedestrian conflicts and crashes:Passive and active analysis approaches显示文摘The importance of investigating pedestrian safety has been evaluated repeatedly in safety studies.The present study attempts to evaluate the various methods used by previous researchers in a hierarchical process,to determine the characteristics,advantages,and limitations of each method.Two general analysis approaches(passive and active) were taken into account to categorize 169 previous types of research.In the passive approach,the studied methods were those based on crash databases,questionnaires,and post-crash field observation data;while,in the active approach,the studied methods were those based on driving simulations and videography.The result of the passive approach reveals that road users’ features and road characteristics(crash database studies),and error,lapses,intentional and unintentional violations(questionnaire studies) by them were among the most important causes of crashes and conflicts.Furthermore,road users’ distractions also reported a set of factors affecting the possibility of conflicts and crashes based on postcrash field observation studies.Also,results of the active approach showed that risky behaviors are the most important factor in threatening pedestrian safety such as unauthorized speeding,non-compliance with traffic law,unauthorized overtaking by drivers,and illegal crossing.Furthermore,risk perception and decision-making processes are the mostimportant bond between the attitude and behavior of road users in dangerous driving situations.Examining studies through passive approach would lead to identifying the causes of crashes,recognizing the attitude of road users towards safety,and determining road users’ behavioral patterns in certain situations,while the active approach has led to a more detailed understanding of behaviors and attitudes of road users.The inference of the findings obtained in this study will lead to a better understanding of the behavior of road users for studies on advanced driving assistance systems(ADAS). | Abbas Sheykhfard Farshidreza Haghighi Eleonora Papadimitriou Pieter Van Gelder | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，5： | 2 |
| 12 | Adaptive and stochastic finite element analysis in drying 显示文摘 | HAGHIGHI A AGUIRRE C G | 1999 | Drying Technology1999，17，10： | 2 |
| 13 | Separation of zinc from manganese, magnesium, calcium and cadmium using batch countercurrent extraction simulation followed by scrubbing and stripping显示文摘 | Hossein Kamran Haghighi Davood Moradkhani Mohammad Mehdi Salarirad | 2015 | Hydrometallurgy2015，，： | 2 |
| 14 | 六自由度IRB-120机器人机械手的滑模控制与边界层控制(英文)显示文摘由于线性PID控制器易于实现,一般采用其对机器人进行控制。线性控制器不能有效地处理不确定性和参数的变化,因此推荐具有鲁棒性能的非线性控制器。滑模控制(SMC)是一种针对非线性系统的鲁棒状态反馈控制方法,其设计简单,有效地克服了系统中的不确定性和扰动,它的瞬态响应非常快,是理想的控制器。SMC最主要的缺点是控制输入信号的抖动。为了解决这一问题,本文采用SMC与边界层(SMCBL)相结合的方法,消除了系统的抖振现象,提高了系统的性能。将所提出的SMCBL与传统的非线性控制方法逆动态控制(IDC)进行了比较。首先,对IRB-120机器人机械手的运动学方程和动力学方程进行了完整、准确的提取;然后,对采用SMC的机器人机械手的控制进行了评价。为了验证该控制方法的有效性,在一个6自由度IRB-120机器人机械手上使用了该控制方法。在MATLAB/Simulink环境下对仿真结果进行了仿真、测试和比较。为了进一步验证我们的工作,在一个实际的IRB-120机器人机械手上进行了测试和实验验证。 | Mojtaba HADI BARHAGHTALAB Vahid MEIGOLI Mohammad Reza GOLBAHAR HAGHIGHI Seyyed Ahmad NAYERI Arash EBRAHIMI | 2018 | Journal of Central South University2018，25，9： | 2 |
| 15 | Evidence of the subperiosteal origin of osteoid osteomes in tubular bones:analysis by CT and MR ima-ging显示文摘 | Resnick D Haghighi P | 1998 | AJR Am J Roentgenol1998，170，3： | 1 |
| 16 | Probiotics stimulate production of natural antibodies in chickens显示文摘 | Haghighi H R Gong J Gyles C L | 2006 | Clin Vaccine Immunol2006，13，9： | 1 |
| 17 | Viscoelastic characterization of the soybean seed coat显示文摘 | Liu M Haghighi K Stroshine R L | 1989 | Transactions of the ASAE1989，32，3： | 1 |
| 18 | Ultrasound Assisted Co-Precipitation of Nanostructured CuO-ZnO-A1203 over HZSM- 5: Effect of Precursor and Irradiation Power on Nanocatalyst Properties and Catalytic Performance for Direct Syngas to DME 显示文摘 | Allahyari S Haghighi M Ebadi A | 2014 | Ultrason Sonochem2014，21，2： | 1 |
| 19 | A Rare, but Life- Threatening Complication of Percutaneous Nephrolithotomy: Massive Intra - Abdominal Extravasation of Irrigation Fluid显示文摘 | Etemadian M Shadpour P Haghighi R | 2012 | Urology journal2012，9，3： | 1 |
| 20 | Experimental measurement and correlation of solubility of β-carotene in pure and ethanol-modified subcritical water显示文摘For the first time,the solubility ofβ-carotene in pure and ethanol-modified subcritical water(SW)using the static method was determined.The experimental runs were performed at a temperature ranging from 298.15 to 403.15 K and 0–10%(w/w)of ethanol as a modifier at a constant pressure of 5 MPa.Samples were analyzed by UV–vis spectrophotometer.The solubility ofβ-carotene was found to range from 1.084×10^-8 to 227.1×10^-8 mol fractions in the subcritical water in above mentioned conditions.The obtainedβ-carotene solubility data were correlated using the linear model and modified Apelblat model.The obtained results showed the modified Apelblat model was better for estimating the solubility ofβ-carotene in SW.The values of the rootmean-square deviation(RMSD)between experimental and correlated data were calculated and used as the index of validity and accuracy for the model.Also,thermodynamic properties of the solution such as the Gibbs free energy of solution,enthalpy,and entropy of solution were estimated. | Hadi Share Mohammadi Ali Haghighi As Maryam Khajenoori | 2020 | Chinese Journal of Chemical Engineering2020，28，10： | 1 |
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