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| 1 | Factors associated with time to laparoscopic cholecystectomy for acute cholecystitis显示文摘AIM: To determine patient and process of care factors associated with performance of timely laparoscopic cholecystectomy for acute cholecystitis. METHODS: A retrospective medical record review of 88 consecutive patients with acute cholecystitis was conducted. Data collected included demographic data, co-morbidities, symptoms and physical findings at presentation, laboratory and radiological investigations, length of stay, complications, and admission service (medical or surgical). Patients not undergoing cholecystectomy during this hospitalization were excluded from analysis. Hierarchical generalized linear models were constructed to assess the association of pre-operative diagnostic procedures, presenting signs, and admitting service with time to surgery.RESULTS: Seventy cases met inclusion and exclusion criteria, among which 12 were admitted to the medical service and 58 to the surgical service. Mean ± SD time to surgery was 39.3 ± 43 h, with 87% of operations performed within 72 h of hospital arrival. In the adjusted models, longer time to surgery was associated with number of diagnostic studies and endoscopic retrograde cholangio-pancreatography (ERCP, P = 0.01) as well with admission to medical service without adjustment for ERCP (P < 0.05). Patients undergoing both magnetic resonance cholangiopancreatography (MRCP) and computed tomography (CT) scans experienced the longest waits for surgery. Patients admitted to the surgical versus medical service underwent surgery earlier (30.4 ± 34.9 vs 82.7 ± 55.1 h, P < 0.01), had less post-operative complications (12% vs 58%, P < 0.01), and shorter length of stay (4.3 ± 3.4 vs 8.1 ± 5.2 d, P < 0.01).CONCLUSION: Admission to the medical service and performance of numerous diagnostic procedures, ERCP, or MRCP combined with CT scan were associated with longer time to surgery. Expeditious performance of ERCP and MRCP and admission of medically stable patients with suspected cholecystitis to the surgical service to speed up time to surgery should be considered. | Chris N Daniak David Peretz Jonathan M Fine Yun Wang Alan K Meinke William B Hale | 2008 | World Journal of Gastroenterology2008，14，7： | 13 |
| 2 | Mycophenolate mofetil for drug-induced vanishing bile duct syndrome显示文摘Amoxicillin/clavulanate is associated with liver injury, mostly of a cholestatic pattern. While outcomes are usually benign, progression to cirrhosis and death has been reported. The role of immunosuppressive therapy for patients with a protracted course is unclear. We report the case of an elderly patient who developed prolonged cholestasis secondary to amoxicillin/clavulanate. Vanishing bile duct syndrome was confirmed by sequential liver biopsies. The patient responded to prednisone treatment, but could not be weaned off corticosteroids, even when azathioprine was added. Complete withdrawal of both prednisone and azathioprine was possible by using mycophenolate mofetil, an inosine monophosphate dehydrogenase inhibitor. Sustained remission has been maintained for more than 3 years with low-dose mycophenolate mofetil. | S Simona Jakab A Brian West Dennis M Meighan Robert S Brown Jr William B Hale | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 3 | National beef tenderness survey-1998显示文摘 | Brooks J C Gwartney J B Hale D S | 2000 | J Anim Sci2000，78，： | 1 |
| 4 | Hypobaric hypoxia impairs spatial memory in an elevation dependent fashion显示文摘 | Hale B Stillman MJ Welch DJ | 1994 | Behav Neural Biol1994，62，3： | 1 |
| 5 | Intravitreal injection of TGFbeta induces cataract in rats显示文摘 | Hales AM Chamberlain CG Dreher B | 1999 | Invest Ophthalmol Vis Sci1999，40，13： | 1 |
| 6 | Synthesis of nervonie acid显示文摘 | HALE J B LYCAN W H | 1930 | J Am Chem Soc1930，，52： | 1 |
| 7 | Effects of cement or lime on Cd, Co, Cu, Ni, Pb, Sb and Zn mobility in field-contaminated and aged soils 显示文摘 | Hale B Evans L Lambert R | 2012 | Journal of Hazardous Materials2012，，： | 1 |
| 8 | Modeling accidents for prioritizing prevention 显示文摘 | Hale A R Ale B J M Goossensa L H J | 2007 | Reliability Engineering and System Safety2007，92，12： | 1 |
| 9 | Insulin resistance, impaired early insulin response, and insulin propeptides as predictors of the development of type 2 diabetes: a population-based, 7-year follow-up study in 70-year-old men 显示文摘 | Zethelius B Hales CN Lithell HO | 2004 | Diabetes Care2004，27，6： | 1 |
| 10 | Induction of apoptosis in the germ cells of adult male rats after exposure to cyclophospha mide显示文摘 | Cai L Hales BF Robaire B | 1997 | Biol Reprod1997，56，6： | 1 |
| 11 | Upper semi continuity of attractors for approximations of semi groups and partial differential equations显示文摘 | Hale J Lin X B Raugel G | 1988 | Math Compup1988，50，： | 1 |
| 12 | The hormone content of ripening grape berries and the effects of growth substance treatments显示文摘 | Coombe B G Hale C R | 1973 | Plant Physiol1973，51，4： | 1 |
| 13 | Thalidomide on the comeback trail 显示文摘 | Hales B | 1999 | Nat Med1999，5，： | 1 |
| 14 | Insulin resistance, impairedearly insulin response, and insulin propeptides as predictorsof the development of type 2 diabetes: a populationbased, 7 -year follow-upstudy in 70-year-old men显示文摘 | Zethelius B Hales CN Lithell HO | 2004 | Diabetes Care2004，27，6： | 1 |
| 15 | Frozen storage stability of whole and headless freshwater prawns ( Machrobranchium rosenbergii ) 显示文摘 | HALE M B WATERS M E | 1981 | Marine Fish Review1981，42，： | 1 |
| 16 | Modeling of safety management systems 显示文摘 | Hale A R Heming B H J Carthey J Kirwan B | 1997 | Safety Science1997，26，1： | 1 |
| 17 | A multifaceted intervention for quality improvement in a network of intensive care units: a cluster ran- domized trial 显示文摘 | Scales DC Dainty K Hales B | 2011 | JAMA2011，305，4： | 1 |
| 18 | National beef tenderness survey 显示文摘 | MORGAN J B SAVELL J W HALE D S | 1991 | J Anita Sci1991，，69： | 1 |
| 19 | Effect of thermal treatment on moisture transport during steam cooking of skipjack tuna (Katsuwonas pelamis)显示文摘 | BELL J W FARKAS B E HALE S A | 2001 | J Food Scie2001，66，2： | 1 |
| 20 | Detection of Clotridium perfrigens alpha toxin using a capture antibody ELISA 显示文摘 | STILES B G | 1999 | Toxico1999，37，： | 1 |
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