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| 1 | Gut bless you:The microbiota-gut-brain axis in irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a common clinical label for medically unexplained gastrointestinal symptoms,recently described as a disturbance of the microbiota-gut-brain axis.Despite decades of research,the pathophysiology of this highly heterogeneous disorder remains elusive.However,a dramatic change in the understanding of the underlying pathophysiological mechanisms surfaced when the importance of gut microbiota protruded the scientific picture.Are we getting any closer to understanding IBS’etiology,or are we drowning in unspecific,conflicting data because we possess limited tools to unravel the cluster of secrets our gut microbiota is concealing?In this comprehensive review we are discussing some of the major important features of IBS and their interaction with gut microbiota,clinical microbiota-altering treatment such as the low FODMAP diet and fecal microbiota transplantation,neuroimaging and methods in microbiota analyses,and current and future challenges with big data analysis in IBS. | Eline Margrete Randulff Hillestad Aina van der Meeren Bharat Halandur Nagaraja Ben RenéBjørsvik Noman Haleem Alfonso Benitez-Paez Yolanda Sanz Trygve Hausken Gülen Arslan Lied Arvid Lundervold Birgitte Berentsen | 2022 | World Journal of Gastroenterology2022，28，4： | 15 |
| 2 | Establishing proof of concept:Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus显示文摘Osteochondral lesions of the talus are common injuries in the athletic patient. They present a challenging clinical problem as cartilage has a poor potential for healing. Current surgical treatments consist of reparative(microfracture) or replacement(autologous osteochondral graft) strategies and demonstrate good clinical outcomes at the short and medium term follow-up. Radiological findings and second-look arthroscopy however, indicate possible poor cartilage repair with evidence of fibrous infill and fissuring of the regenerative tissue following microfracture. Longer-term follow-up echoes these findings as it demonstrates a decline in clinical outcome. The nature of the cartilage repair that occurs for an osteochondral graft to become integrated with the native surround tissue is also of concern. Studies have shown evidence of poor cartilage integration,with chondrocyte death at the periphery of the graft, possibly causing cyst formation due to synovial fluid ingress. Biological adjuncts, in the form of platelet-rich plasma(PRP) and bone marrow aspirate concentrate(BMAC), have been investigated with regard to their potential in improving cartilage repair in both in vitro and in vitro settings. The in vitro literature indicates that these biological adjuncts may increase chondrocyte proliferation as well as synthetic capability, while limiting the catabolic effects of an inflammatory joint environment. These findings have been extrapolated to in vitro animal models, with results showing that both PRP and BMAC improve cartilage repair. The basic science literature therefore establishes the proof of concept that biological adjuncts may improve cartilage repair when used in conjunction with reparative and replacement treatment strategies for osteochondral lesions of the talus. | Niall A Smyth Christopher D Murawski Amgad M Haleem Charles P Hannon Ian Savage-Elliott John G Kennedy | 2012 | World Journal of Orthopedics2012，3，7： | 8 |
| 3 | Complex ankle arthrodesis: Review of the literature显示文摘Complex ankle arthrodesis is defined as an ankle fusion that is at high risk of delayed and nonunion secondary to patient comorbidities and/or local ankle/hindfoot factors. Risk factors that contribute to defining this group of patients can be divided into systemic factors and local factors pertaining to co-existing ankle or hindfoot pathology. Orthopaedic surgeons should be aware of these risk factors and their association with patients' outcomes after complex ankle fusions. Both external and internal fixations have demonstrated positive outcomes with regards to achieving stable fixation and minimizing infection. Recent innovations in the application of biophysical agents and devices have shown promising results as adjuncts for healing. Both osteoconductive and osteoinductive agents have been effectively utilized as biological adjuncts for bone healing with low complication rates. Devices such as pulsed electromagnetic field bone stimulators, internal direct current stimulators and low-intensity pulsed ultrasound bone stimulators have been associated with faster bone healing and improved outcomes scores when compared with controls. The aim of this review article is to present a comprehensive approach to the management of complex ankle fusions, including the use of biophysical adjuncts for healing and a proposed algorithm for their treatment. | Remy V Rabinovich Amgad M Haleem S Robert Rozbruch | 2015 | World Journal of Orthopedics2015，6，8： | 7 |
| 4 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 5 | Unsaturated-sulfur-rich MoS2 nanosheets decorated on free-standing SWNT film: Synthesis, characterization and electrocatalytic application显示文摘此处,我们报导一条自底向上的 solvothermal 线路综合为氢进化反应的灵活、高度有效的瞬间 2@SWNT electrocatalyst (她的) 。描述表明包含 sulfurrich 地点的像分支的瞬间 2 nanosheets 在一致地在自立的围单人赛的碳 nanotube (SWNT ) 上驱散的 situ 电影,能暴露更不饱和的硫原子,与活跃地点允许优秀电的接触。展出的灵活催化剂优秀她有低过电位的表演(~ 在 10 妈 / 厘米 2) 和小 Tafel 斜坡(41 mV/dec ) 的 150 mV。为了推进,解释改进表演,本地电子结构被 X 光检查吸收调查近边的结构(XANES ) 分析,证明不饱和的硫原子并且在瞬间 2 和 SWNT 之间的强壮的电子联合的存在。这研究提供一条在原处合成的线路在催化剂微观结构,电子结构,和性质之中创造新多功能的灵活 hybridized 催化剂和有用卓见进关系。 | Daobin Liu Weiyu Xu Qin Liu Qun He Yasir A. Haleem Changda Wang Ting Xiang Chongwen Zou Wangsheng Chu Jun Zhong Zhiqiang Niu Li Song | 2016 | Nano Research2016，9，7： | 7 |
| 6 | In situ trapped high-density single metal atoms within graphene: Iron-containing hybrids as representatives for efficient oxygen reduction显示文摘因为他们为特殊催化作用的效率和 chemoselectivity 比传统的催化剂的那些优异,原子地驱散的催化剂在精力变换应用吸引了注意。然而,他们在支持上由于极其低的装载金属的内容有限制,在在高温度的金属地点和数量以及低稳定性的精确控制的困难。我们经由葡萄糖, dicyandiamide,和无机的金属盐的单个步的热热分解准备了一个高度做的单个金属原子混血儿。高角度的环形的黑暗扫描地的传播电子显微镜学(HAADF 茎) 和 X 光检查吸收罚款结构光谱学(XAFS ) 表明做进 graphene 矩阵的氮原子为由产生 metal-Nx 协作结构的金属原子稳定是枢轴的。由于 graphene 矩阵的强壮的抛锚效果,装载内容的金属是在孤立的原子混血儿的超过 4 wt.%( 磅内容象在做磅的混血儿的 9.26 wt.% 一样高) 。而且,单个做铁的混血儿(做 Fe@N 的 graphene ) 为氧减小反应显示出显著 electrocatalytic 表演。山峰力量密度是 199 | Daobin Liu Chuanqiang Wu Shuangming Chen Shiqing Ding Yaofeng Xie Changda Wang Tao Wang Yasir A. Haleem Zia ur Rehman Yuan Sang Qin Liu Xusheng Zheng Yu Wang Binghui Ge Hangxun Xu Li Song | 2018 | Nano Research2018，11，4： | 6 |
| 7 | Predictions of future hydrological conditions and contribution of snow and ice melt in total discharge of Shigar River Basin in Central Karakoram,Pakistan显示文摘The high mountains of Hindu-Kush Karakoram and Himalaya(HKKH) contain a large volume of snow and ice, which are the primary sources of water for the entire mountainous population of HKKH. Thus, knowledge of these available resources is very important in relation to their sustainable use. A Modified Positive Degree Day Model was used to simulate daily discharge with the contribution of snow and ice melt from the Shigar River Basin, Central Karakoram, Pakistan. The basin covers an area of 6,921 km2 with an elevation range of 2,204 to 8,611 m a.s.l.. Forty percent of the total area is glaciated among which 20% is covered by debris and remaining 80% by clean ice and permanent snow. To simulate daily discharge, the entire basin was divided into 26 altitude belts. Remotely sensed land cover types are derived by classifying Landsat images of 2009. Daily temperature and precipitation from Skardu meteorological station is used to calibrate the glacio-hydrological model as an input variable after correlating data with the Shigar station data(r=0.88). Local temperature lapse rate of 0.0075 °C/m is used. 2 °C critical temperature is used to separate rain and snow from precipitation. The model is calibrated for 1988~1991 and validated for 1992~1997. The model shows a good Nash-Sutcliffe efficiency and volume difference in calibration(0.86% and 0.90%) and validation(0.78% and 6.85%). Contribution of snow and ice melt in discharge is 32.37% in calibration period and 33.01% is validation period. The model is also used to predict future hydrological regime up to 2099 by using CORDEX South Asia RCM considering RCP4.5 and RCP8.5 climate scenarios.Predicted future snow and ice melt contributions in both RCP4.5 and RCP8.5 are 36% and 37%, respectively. Temperature seems to be more sensitive as compared to other input variables, which is why the contribution of snow and ice in discharge varies significantly throughout the whole century. | Javed Hassan Rijan Bhakta Kayastha Ahuti Shrestha Iram Bano Sayed Hammad Ali Haleem Zaman Magsi | 2017 | Research in Cold and Arid Regions2017，9，6： | 3 |
| 8 | PUFA加固钢筋混凝土柱抗震性能数值模拟显示文摘汶川特大地震后,交通运输部颁布了新的《公路桥梁抗震设计细则》,采用了两水平设防,两阶段设计的抗震设计理念,由单一的强度设计修改为由强度和变形等多指标控制的抗震设计方法。但是,对于现役钢筋混凝土桥墩而言,如何通过科学的抗震加固方法来增加其变形能力乃是提高我国整体桥梁结构抗震水平的关键。采用新型材料PUFA材料,对现役钢筋混凝土桥墩进行了抗震加固设计。为了验证其抗震加固效果,利用OpenSees软件对每个加固模型分别进行了PUSHOVER数值解析,并与常用的混凝土加大截面法和粘贴碳纤维加固法的加固效果进行分析比较。研究结果表明:利用PUFA进行抗震加固不仅可以切实提高钢筋混凝土桥墩的韧性,而且比常规的抗震加固方法具有更好的抗震加固效果。 | 李永学 刘贵位 Haleem K.Hussain 于文 邓晓琼 | 2011 | 公路2011，56，6： | 3 |
| 9 | Blockchain technology applications for Industry 4.0:A literature-based review显示文摘Industry 4.0 involves innovations with upcoming digital technologies,and blockchain is one of them.Blockchain can be incorporated to improve security,privacy,and data transparency both for small and large enterprises.Industry 4.0 is a synthesis of the new production methods that allow manufacturers to achieve their target more rapidly.Research has been conducted on various Industry 4.0 technologies like Artificial Intelligence(AI),Internet of Things(IoT),Big data,and Blockchain,and how they could create significant interruptions in recent years.These technologies provide various possibilities in the world of manufacturing and supply chain.Blockchain is a technology that has gained much recognition and can enhance the manufacturing and supply chain environment.Various fields now have fascinating insights into the advantages of blockchain.Several research articles on“Blockchain”and“Industry 4.0”from Google Scholar,Scopus,and other relevant sources are identified and reviewed for this study.This paper discusses the major potential of Blockchain in Industry 4.0.Various drivers,enablers,and associated capabilities of Blockchain technology for Industry 4.0 are discussed for insights.Different Industry 4.0 spheres/sub-domains for Blockchain technology realisation are also discussed.Finally,we have identified and studied fourteen significant applications of Blockchain in Industry 4.0.It is a range of new developments and hope for immense opportunities that are changing Industry 4.0.This technology would work to achieve amplified outcomes and work individually to enhance the process. | Mohd Javaid Abid Haleem Ravi Pratap Singh Shahbaz Khan Rajiv Suman | 2021 | Blockchain(Research and Applications)2021，2，4： | 2 |
| 10 | Accumulation of heavy metals in two crop seeds due to soil contamination as determined by neutron activation analysis techniques显示文摘AcumulationofheavymetalsintwocropsedsduetosoilcontaminationasdeterminedbyneutronactivationanalysistechniquesM.F.AbdelSabourS... | M.F.Abdel Sabour Soil and Water Department, Nuclear Research Center, Cairo, Egypt A.S.Abdel Haleem Hot Lab’s Center, Atomic Energy Authority, Cairo, Egypt A.Sroor, N.Abdel Baset Nuclear Physics Lab, Girls Faculty, Ain Shams University, Egypt R.A.Zaghloul Mubarak City for Scientific Research and Technology, Egypt | 1998 | Journal of Environmental Sciences1998，10，2： | 2 |
| 11 | Traceability implementation in food supply chain: A grey-DEMATEL approach显示文摘Numerous incidents of food adulteration,fraudulence and foodborne disease outbreaks have shaken the consumer confidence towards the food they consume.These incidents compel the Food Supply Chain(FSC)partners to implement an appropriate traceability system in their respective supply chains to sustain the consumer confidence.The objective of this research is to identify the drivers(major factors)which play a significant role in the successful implementation of the traceability system in FSC and evaluate the causal relationships developing therein.Twelve drivers are identified towards implementation of the traceability system in FSC through literature review and supported with expert’s opinion.The grey-based DEMATEL approach is identified to evaluate these relationships among the drivers according to their net effect.Further,these drivers ranked based on the prominence and effect score.The finding of this research shows that the drivers are clustered into two groups namely:influential(cause)and influenced(effect)group.Four drivers belong to the influential group,and remaining eight are from the influenced group.The most influential driver is the “food safety and quality”which provide a significant effect on the implementation of a traceability system.This research can be a building block to develop a framework to implement the traceability system within FSC and assist the policymakers,and practitioners to identify and evaluate drivers related to the implementation of traceability system in FSC.This paper also provides a useful insight&support to the practitioners and managers in decision making for traceability implementation related issues。 | Abid Haleem Shahbaz Khan Mohd Imran Khan | 2019 | Information Processing in Agriculture2019，6，3： | 2 |
| 12 | Mortality following hip fracture:Trends and geographical variations over the last 40 years 显示文摘 | Haleem S Lutchman L Mayahi R | 2008 | Injury2008，39，： | 1 |
| 13 | High-metallic-phase-concentration MO1-xWxS2 nanosheets with expanded interlayers as efficient electrocatalysts显示文摘 | Qun He Yangyang Wan Hongliang Jiang Chuanqiang Wu Zhongti Sun Shuangming Chen Yu Zhou Haiping Chen Daobin Liu Yasir A. Haleem Binghui Ge Xiaojun Wu Li Song | 2018 | Nano Research2018，11，3： | 1 |
| 14 | Wedge factor dependence on depth and field size for various beam energies using symmetric and half-collimated asymmetric jaw settings显示文摘 | Mahmoud Haleem Jama Rodyers | 1992 | Medical Physical1992，19，6： | 1 |
| 15 | Audiometric changes following spinal anaesthesia显示文摘 | Haleem S Ansari MM Shakoor A | 1993 | J Pak Med Assoc1993，43，3： | 1 |
| 16 | Mortality following hip fracture: trends and geographicals variations over the last 40 years显示文摘 | Haleem S Lutehman L Mayahi R | 2008 | Injury2008，39，： | 1 |
| 17 | Attenuation of apomorpbine-induced sensiti- zation by buspimne 显示文摘 | Ikram H Haleem DJ | | Pharmaeol Biochem Behav0，99，： | 1 |
| 18 | Mortality following hip fracture: Trends and geographical variations over the last 40 years 显示文摘 | Haleem S Lutchman L Mayahi R | 2008 | Injury2008，39，10： | 1 |
| 19 | Optoelectronic Properties, Elastic Moduli and Thermoelectricity of SrAlGa: An Ab Initio Study显示文摘 | Roshan Ali G. Murtaza Y. Takagiwa R. Khenata Haleem Uddin H. Ullah S. A. Khan | 2014 | Chinese Physics Letters2014，31，4： | 1 |
| 20 | The lectin pathway of comple- ment activation is a critical component of the innate immune response to pneumococcal infection 显示文摘 | All YM Lynch NJ Haleem KS | 2012 | PLoS Pathog2012，8，10： | 1 |
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