|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Endoscopic treatment modalities and outcomes in nonvariceal upper gastrointestinal bleeding显示文摘BACKGROUND In nonvariceal upper gastrointestinal bleeding(NVUGIB),the optimal volume of adrenaline,the optimal number of hemoclips,and the application of thermal coagulation in determining patient outcomes have not been well studied.AIM To demonstrate a dose-response relationship between the commonly used endoscopic modalities for the treatment of non-variceal upper gastrointestinal bleeding and various clinical outcomes.METHODS Patients presenting with NVUGIB were retrospectively identified and analyzed.These patients were stratified as follows:(1)>10 mL of adrenaline injected vs≤10 mL;(2)>1 hemoclip placed vs≤1 hemoclip;(3)Heater probe used or not;and(4)>2 treatment modalities used vs≤2.The primary outcomes were rebleeding and the need for repeat endoscopy.The secondary outcomes were the need for surgery,required transfusions,length of hospital stay,death during the same admission period and 30 d mortality.Patients with NVUGIB who required endoscopic therapy were included.Those who did not require endoscopic therapy or were initially treated with surgery or embolization were excluded.RESULTS In all,501 patients with NVUGIB were treated.One hundred sixty-one(32.1%)patients needed endoscopic therapy.The injection of<10 mL of adrenaline was associated with less rebleeding(P<0.0001),the need for repeat endoscopy(P=0.001)and a decreased length of hospital stay(P=0.026).The use of>2 treatment modalities were associated with increased rebleeding(P=0.009)and the need for repeat endoscopy(P=0.048).The placement of>1 hemoclip was associated with a decreased length of hospital stay(P=0.044).The rates of surgery and death were low,and there were no other significant differences between the patient groups.CONCLUSION The more restrictive use of adrenaline and number of endoscopic modalities to treat NVUGIB with the more liberal use of hemoclips was associated with better patient outcomes. | Benjamin Cherng Hann Yip Hossain Sayeed Sajjad Jie-Xun Wang Constantinos P Anastassiades | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，2： | 2 |
| 3 | The signal recognition particle in Saccharomyces cerevisiae显示文摘 | Hann BC Walter P | 1991 | Cell1991，67，： | 1 |
| 4 | Detecting highly oscillatory signals by chirplet path pursuit显示文摘 | CANDèS E J CHARLTON P R Hannes helgason | 2008 | Applied and Computational Harmonic Analysis2008，24，1： | 1 |
| 5 | Crown profile equations for stand-grown western hemlock trees in northwestern Oregon显示文摘 | MARSHALL D D JOHNSON G P HANN D W | 2003 | Can J For Res2003，33，11： | 1 |
| 6 | Crown profile equations for stand-grown western hemlock trees in northwestern Oregon 显示文摘 | Marshall D D Johnson G P Hann D W | 2003 | Canadian Journal of Forest Research-Revue Canadienne de Re- cherche Forestiere2003，33，11： | 1 |
| 7 | Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine - resistant chronic hepatitis B 显示文摘 | Peters MG Hann HW Martin P | 2004 | Gastroenterology2004，126，1： | 1 |
| 8 | Adefovir dipivoxil (ADV) alone and in combination with lamivudine (LAM)suppress YMDD mutant hepatitis B virus replication:48 week preliminary analysis显示文摘 | Marion P H W Hann P Martin | 2002 | Hepatology2002，36，： | 1 |
| 9 | Improved secondary metabolite production in the genus Streptosporangium by optimization of the fermentation conditions显示文摘 | Chrisotph P Uwe T Hanne G | 2000 | Biotechnology2000，80，： | 1 |
| 10 | Localization of a susceptibilitylocus for schizophrenia on chromosome 5显示文摘 | Robin S Jon B Hannes P | 2008 | Nature2008，336，10： | 1 |
| 11 | Transforming growth factor beta in relation to cardic allograft vaculopathy after heart transplantation显示文摘 | Aziz T Hasleton P Hann AW | 2000 | J Thorac Cardiovasc Surg2000，119，4： | 1 |
| 12 | Adefovir dipivoxil alone or in combination with lamivudine in patientswith lamivudine-resistant chronic hepatitisB 显示文摘 | PETERS MG HANN HW MARTIN P | 2004 | Gastroenterology2004，126，1： | 1 |
| 13 | Influence of VA mycorrhizae on the uptake and distribution of heavy metals in plants显示文摘 | BARBARA D HANNES S P | 1989 | Agrieulture Ecosystems and Environmen1989，29，： | 1 |
| 14 | Measurement of fatigue in cancer patients:Development and validation of the fatigue symptom inventory显示文摘 | Hann D M Jacobsen P B Azzarello L M | 1998 | Qual Life Res1998，7，4： | 1 |
| 15 | Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B显示文摘 | Peters M G Hann H W Martin P | 2004 | Gastroenterology2004，162，1： | 1 |
| 16 | Adefovir dipivoxil alone or in combination with lamivucline in patients with lamivudine resistant chronic hepatitis B显示文摘 | Peters M G Hann Hw H Martin P Heathcote E J Buggisch P Rubin R | 2004 | Gastroenterology2004，126，： | 1 |
| 17 | Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudineresistant chronic hepatitis B 显示文摘 | Peters M G Hann H W Martin P | 2004 | Gastroenterology2004，126，1： | 1 |
| 18 | Adefovir Dipivoxil Alone or in Combination with Lamivudine in Patients with Lamivudine-resistant Chronic Hepatitis B 显示文摘 | Peters M G Hann H W Martin P | 2004 | Gastroenterology2004，126，1： | 1 |
| 19 | Phase II trial of docetaxel in patients with platinum refractory advanced ovarian cancer显示文摘 | Francis P Schneider J Hann L | 1994 | J Clin Oncol1994，12，11： | 1 |
| 20 | Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine -resistant chronic hepatitis B 显示文摘 | Peters MG Hann Hw H Martin P | 2004 | Gastroenter- ology2004，126，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员