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| 1 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 2 | A Mixed micellar formulation suitable for the parenteral administration of taxol显示文摘 | Hayat AO Suganthi R Hee-Byung Chai | 1994 | Pharm Res1994，11，2： | 1 |
| 3 | Scene-based nonuniformity correction with video sequences and registration显示文摘 | Hardie R C Hayat M M Armstrong E E | 2000 | Applied Optics2000，39，： | 1 |
| 4 | Sorer-Dufour effects on three-dimensional flow of third grade fluid显示文摘 | HAYAT T NAZ R ASGHAR S MESLOUB S | 2012 | Nuclear Engineering and Design2012，243，： | 1 |
| 5 | Peritoneal dialysis for adults with acute renal failure:an underutilized modality显示文摘 | Hayat A Kamili MA Samia R | 2007 | Saudi J Kidney Dis Transpl2007，18，2： | 1 |
| 6 | An algebraic algorithm for nonuniformity correction in focal-plane arrays 显示文摘 | Ratliff B M Hayat M M Hardie R C | 2002 | J Opt Soc Am A2002，19，9： | 1 |
| 7 | Villoglandular adeno- carcinoma of the cervix: clarity is needed on the histological defini- tion for this difficult diagnosis 显示文摘 | Macdonald R D Kirwan J Hayat K | 2006 | Gynecol Oncol2006，100，1： | 1 |
| 8 | Disease activ- ity and cytokine production in mitogen-stimulated peripheral blood mononuclear ceils from patients with rheumatoid arthritis显示文摘 | UPPAL SS RAGHUPATHY R HAYAT SJ | 2010 | Med Princ Pract2010，19，1： | 1 |
| 9 | Functional differences andinteractions between phenotypie subpopulations of olfactory ensheathing cells in promoting CNS axonal regeneration显示文摘 | jKumar R Hayat S Felts P | 2005 | Glia2005，50，1： | 1 |
| 10 | Soil beneficial bacte- ria and their role in plant growth promotion: a review 显示文摘 | Hayat R Ali S Amara U | 2010 | AnnMicrobiol2010，60，4： | 1 |
| 11 | Characterization and identification of compost bacteria based on 16S rRNA gene sequencing 显示文摘 | Hayat R Sheirdil R Iflikhar M | 2013 | Annals of Microbiology2013，63，3： | 1 |
| 12 | Numerical study of MHD nanofluid flow and heat transfer past a bidirectional exponentially stretching sheet显示文摘 | AHMAD R MUTAFA M HAYAT T | 2016 | Journal of Magnetism & Magnetic Materials2016，407，： | 1 |
| 13 | Information needs and seeking behaviour of business students显示文摘 | Majid S Hayat I Pate1 R P | 2012 | Singapore Journal of Library & Information Management2012，41，： | 1 |
| 14 | An algebraic algorithm for nonuniformity correction in focal-plane arrays 显示文摘 | B M Ratliff M M Hayat R C Hardie | 2002 | The Journal of the Optical Society of America A2002，19，： | 1 |
| 15 | Diabetic cardiomyopathy:mechanisms,diagnosis and treatment显示文摘 | Hayat S A Patel B Khattar R S | 2004 | Clin Sci(Colch)2004，107，6： | 1 |
| 16 | Diagnostic yield and effect on clinical outcomes of push enteroscopy in suspected small-bowel bleeding显示文摘 | HAYAT M AXON A T R O'MAHONY S | 2000 | Endoscopy2000，32，： | 1 |
| 17 | Comparison between myocardial contrast echocardiography and single-photon emission computed tomography for predicting transmurality of acute myocardial infarction 显示文摘 | Hayat SA Janardbenan R Moon JCC | 2006 | Am J Cardiol2006，97，： | 1 |
| 18 | A microvisual study of solution-gas-drive mechanisms in viscous oils显示文摘 | GEORGE D S HAYAT O KOVSCEK A R | 2005 | Journal of Petrole- um Science and Engineering2005，46，1： | 1 |
| 19 | Prognostic value of myocardial vi- ability detected by myocardial contrast echocardiography early after acute myo- cardial infarction 显示文摘 | Dwivedi G Janardhanan R Hayat S | 2007 | J Am Coil Cardiol2007，50，： | 1 |
| 20 | On the homotopy solution for Poiseuille flow of a fourth grade fluid显示文摘 | Hayat T Naz R Sajid M | 2010 | Communications in Nonlinear Science and Numerical Simulation2010，15，3： | 1 |
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