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| 1 | Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation显示文摘Mesenchymal stem cell(MSC)-based treatments have shown promise for improving tendon healing and repair.MSCs have the potential to differentiate into multiple lineages in response to select chemical and physical stimuli, including into tenocytes. Cell elongation and cytoskeletal tension have been shown to be instrumental to the process of MSC differentiation. Previous studies have shown that inhibition of stress fiber formation leads MSCs to default toward an adipogenic lineage, which suggests that stress fibers are required for MSCs to sense the environmental factors that can induce differentiation into tenocytes. As the Rho/ROCK signal transduction pathway plays a critical role in both stress fiber formation and in cell sensation, we examined whether the activation of this pathway was required when inducing MSC tendon differentiation using rope-like silk scaffolds. To accomplish this, we employed a loss-of-function approach by knocking out ROCK,actin and myosin(two other components of the pathway) using the specific inhibitors Y-27632, Latrunculin A and blebbistatin, respectively. We demonstrated that independently disrupting the cytoskeleton and the Rho/ROCK pathway abolished the expression of tendon differentiation markers and led to a loss of spindle morphology. Together, these studies suggest that the tension that is generated by MSC elongation is essential for MSC teno-differentiation and that the Rho/ROCK pathway is a critical mediator of tendon differentiation on rope-like silk scaffolds. | Edward Maharam Miguel Yaport Nathaniel L Villanueva Takintope Akinyibi Damien Laudier Zhiyong He Daniel J Leong Hui B Sun | 2015 | Bone Research2015，3，3： | 4 |
| 2 | Mechanical properties of a biodegradable bone regeneration scaffold显示文摘 | Porter B D Oldham J B He S L | 2000 | J Biomech Eng2000，122，3： | 2 |
| 3 | 缺血性脑卒中后的中期血压变异性与临床结局的关系显示文摘本研究旨在探讨急性脑卒中患者发病7d内的中期血压变异性(blood pressure variability,BPV)与预后的关系。方法:本研究纳入873例急性缺血性脑卒中患者。通过计算发病7d内的收缩压和舒张压的变异系数来评价中期BPV。 | Wang Y Wang J Meng P Liu N Ji N Zhang G Xu B Zhou X Sun Y Xu Y Hui R He M 陈云 叶鹏 | 2018 | 中华高血压杂志2018，26，5： | 2 |
| 4 | Research outline on extension mathematics显示文摘 | He B Chen J | 1997 | ACM SIGICE Bulletin1997，22，3： | 1 |
| 5 | Electrodeposition of Pt-Ru nanoparticles on carbon nanotubes and their electrocatalytic properties for methanol electrooxidation 显示文摘 | He Z B Chen J H Liu D Y | 2004 | Diamond and Related Materials2004，13，10： | 1 |
| 6 | Speciation of heavy metals in marine sediments from the East China Sea by ICP-MS with sequential extraction显示文摘 | Yuan C G Shi J B He B | 2004 | Environment International2004，30，： | 1 |
| 7 | disturbance attenuation for state delayed systems 显示文摘 | Wang Q G Lee T H | 1998 | System & Control Letters1998，33，： | 1 |
| 8 | Superparamagnetic Fe2O3 beads-CdSe/ZnS quantum dots core-shell nanoeomposite particles for Ce separation显示文摘 | Wang D S He J B | 2004 | NanoLetter2004，4，： | 1 |
| 9 | Energetics of charged point defects in rutile TiO2 by density functional theory显示文摘 | LI X FINNIS M W HE J BEHERA R K PHILLPOT S R SINNOTT S B DICKEY E C | 2009 | Acta Materialia2009，57，： | 1 |
| 10 | Alterations of bile acid composition in gallstones, bile and live of patients with hepatolithiesis and the etiological significante显示文摘 | Shoda J Tanaka N He B | 1993 | Dig Dis Sci1993，38，11： | 1 |
| 11 | Aspirin and risk of hemorrhagic stroke:a meta-analysis of randomized controlled trials显示文摘 | He J Whelton PK Vu B | 1998 | JAMA1998，280，： | 1 |
| 12 | Effect of food on the pharmacokinetics of a vildagliptin/metfor rain (50/1 000 rag) fixed-dose combination tablet in healthy volunteers 显示文摘 | HE Y L FLANNERY B CAMPESTRINI J | 2008 | Curr Med Res Opin2008，24，6： | 1 |
| 13 | Hepatitis B virus with a pro- posed genotype I was found in sichuan province,China显示文摘 | TONG W B HE J L SUN L | 2012 | J Med Viro12012，84，6： | 1 |
| 14 | Mechanical properties of single crystal tungsten microwhiskers characterized by nanoindentation 显示文摘 | HUANG H WU Y Q WANG S L HE Y H ZOU J HUANG B Y LIU C T | 2009 | Materials Science and Engeering A2009，53，12： | 1 |
| 15 | Compliant needle modeling and steerable insertion simulation 显示文摘 | Tang L B Chen Y H He X J | 2008 | Computer-Aided Design and Applications2008，5，1234： | 1 |
| 16 | 显示文摘 | He J B Lin X Q Pan J | 2005 | Electroanal2005，17，18： | 1 |
| 17 | Catalytic formation of ethylene carbonate from supercritical carbon dioxide/ethylene oxide mixture with tetradentate schiff-base complexes as catalyst显示文摘 | Lu X B Feng X J He R | | 0，，： | 1 |
| 18 | Effect of CdF2 addition on thermal stability and upconversion luminescence properties in Tm3+-Ybif codoped oxyfluoride silicate glasses显示文摘 | Duan Z C Zhang J J He D B | 2006 | Materials Chemistry & Physics2006，100，23： | 1 |
| 19 | Decomposition of Abies faxoniana litter varies with freeze–thaw stages and altitudes in subalpine/alpine forests of southwest China 显示文摘 | Zhu J He X Wu F Yang W Tan B | 2012 | Scand J For Res2012，27，： | 1 |
| 20 | Effect of litter quality on its decomposition in broadleaf and coniferous forest显示文摘 | Zhang P Tian X J He X B | 2008 | European Journal of Soil Biology2008，44，4： | 1 |
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