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| 1 | Noninvasive methods for prediction of esophageal varices in pediatric patients with portal hypertension显示文摘AIM: To evaluate clinical and laboratory parameters for prediction of bleeding from esophageal varices (EV) in children with portal hypertension. METHODS: Retrospective study of 103 children (mean age: 10.1 ± 7.7 years), 95.1% with intrahepatic portal hypertension. All patients had no history of bleeding and underwent esophagogastroduodenoscopy for EV screening. We recorded variceal size (F1, F2 and F3), red-color signs and portal gastropathy, according to the Japanese Research Society for Portal Hypertension classification. Patients were classified into two groups: with and without EV. Seven noninvasive markers were evaluated as potential predictors of EV: (1) platelet count; (2) spleen size z score, expressed as a standard deviation score relative to normal values for age; (3)platelet count to spleen size z score ratio; (4) platelets count to spleen size (cm) ratio; (5) the clinical prediction rule (CPR); (6) the aspartate aminotransferase to platelet ratio index (APRI); and (7) the risk score. RESULTS: Seventy-one children had EV on first endoscopy. On univariate analysis, spleen size, platelets, CPR, risk score, APRI, and platelet count to spleen size z score ratio showed significant associations. The best noninvasive predictors of EV were platelet count [area under the receiver operating characteristic curve (AUROC) 0.82; 95%CI: 0.73-0.91], platelet: spleen size z score (AUROC 0.78; 95%CI: 0.67-0.88), CPR (AUROC 0.77; 95%CI: 0.64-0.89), and risk score (AUROC 0.77; 95%CI: 0.66-0.88). A logistic regression model was applied with EV as the dependent variable and corrected by albumin, bilirubin and spleen size z score. Children with a CPR < 114 were 20.7-fold more likely to have EV compared to children with CPR > 114. A risk score > -1.2 increased the likelihood of EV (odds ratio 7.47; 95%CI: 2.06-26.99). CONCLUSION: Children with portal hypertension with a CPR below 114 and a risk score greater than -1.2 are more likely to have present EV. Therefore, these two tests can be helpful in selecting children for endoscopy. | Marina Rossato Adami Cristina Targa Ferreira Carlos Oscar Kieling Vania Hirakata Sandra Maria Gonalves Vieira | 2013 | World Journal of Gastroenterology2013，19，13： | 4 |
| 2 | The effect of azelastm hydrochloride on pruritus and leukotriene B4 in hemodialysis patients 显示文摘 | Kanai H Nagashima A Hirakata E | 1995 | Life Sci1995，57，3： | 1 |
| 3 | Clinical characteris- tics of Japanese patients with anti-PL-7 ( anti-threonyl-tRNA synthetase) autoantibodies 显示文摘 | Sato S Hirakata M Kuwana M | 2005 | Clin Exp Rheumatol2005，23，： | 1 |
| 4 | Comparison ot usefulness of plasma procaleition and C-reactive protein measure- ments for estimation of severity in adults with community acquired pneumonia 显示文摘 | Hirakata Y Yanagihara K Kurihara S | 2008 | Diagn Microbiol Infect Dis2008，61，2： | 1 |
| 5 | Generation control circuit for photovoltaic modules显示文摘 | SHIMIZU T HIRAKATA M KAMEZAWA T | 2001 | IEEE Transactions on Power Electronics2001，16，3： | 1 |
| 6 | The effect of azelastin hydrochloride on pruritus and leukotriene B4 in hemodialysis patients显示文摘 | Nagashima A Hirakata E | 1995 | Life Sci1995，57，3： | 1 |
| 7 | Rapid identification of penicillin and macrolide resistance genes and simultaneous quantification of Streptococcus pneumoniae in purulent sputum samples by use of a novel real-time multiplex PCR assay显示文摘 | FUKUSHIMA K Y YANAGIHARA K HIRAKATA Y | 2008 | J Clin Microbiol2008，46，7： | 1 |
| 8 | Aberrant expression of caspase cascade regulatory genes in adult T-cell leukemia: surviving is an important determinant for prognosis显示文摘 | Kamihira S Yamada Y Hirakata Y | 2001 | Br J Haematol2001，14，1： | 1 |
| 9 | Drug susceptibility of bacteria isolated from pediatric respiratory infections at general practitioners'clinics to pediatric antibiotics显示文摘 | Hirakata Y Komatsu M Muratani T | 2009 | Jpn J Antibiot2009，62，： | 1 |
| 10 | Autoantibodies to a 140kd polypep- tide, MDAS,in Japanese patients with clinically amyopathic dermatomyo- sitis显示文摘 | SatoS Hirakata M Kuwana M | 2005 | Arthritis Rheum2005，52，6： | 1 |
| 11 | Interstitial Lung disease in polymyositis and dermatomyositis 显示文摘 | Hirakata M Nagai S | 2000 | Curr opin Rheumatol2000，12，： | 1 |
| 12 | Depression and perceptionsof quality of life of breast cancer survivors and their male partners 显示文摘 | Rabin EG Heldt E Hirakata VN | 2009 | Oncol Nurs Forum2009，36，3： | 1 |
| 13 | Japanese Society for Dialysis Therapy guidelines for management of cardiovascular diseases in patients on chronic hemodialysis显示文摘 | Hirakata H Nitta K Inaba M | 2012 | Ther Apher Dial2012，16，5： | 1 |
| 14 | Direct vasoconstrictor and vasodilator effects of propofol in isolated dogarteries显示文摘 | NAKAMURA K HATANO Y HIRAKATA H | 2002 | Anaesthesia2002，6868，： | 1 |
| 15 | Locally activated renin-angiotensin system associated with TGF-β1 as a major factor for renal injury induced by chronic inhibition of nitric oxide synthase in rats 显示文摘 | Kashiwagi M Shinozaki M Hirakata H | 2000 | J Am Soc Nephrol2000，11，4： | 1 |
| 16 | Combination therapy using prednisolone and cyclophosphamide slows the progression of moderately advanced IgA nephropathy显示文摘 | Tsuruya S Harada MA Hirakata H | 2000 | Clin Nephrol2000，53，： | 1 |
| 17 | Significant relationship of matrix metalloproteinase 9 with nuclear grade and prognostic impact of tissue inhibitor of metalloproteinase 2 for incidental clear cell renal cell carcinoma 显示文摘 | Kawata N Nagane Y Hirakata H | 2007 | Urology2007，69，： | 1 |
| 18 | Autoantibodies to a 140-kd polypeptide,CADM-140,in Japanese patients with clinically amyopathic dermatomyositis显示文摘 | Sato S Hirakata M Kuwana M | | 0，，5： | 1 |
| 19 | Aherrant expression of caspase cascade regulatory genes in adult T cell leukemia; survivin is an important determinant for prognosis显示文摘 | Kamihira S Yamada Y Hirakata Y | 2001 | Bt J Haematol2001，114，2： | 1 |
| 20 | Rapid detection and evaluation of clinical characteristics of emerging multiple-drugresistant gram-negative rods carrying the metallo-bata-lactamase gene bla IMP显示文摘 | Hirakata Y Izumikawa K Yamaguchi T | | 0，，08： | 1 |
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