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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 3 | Identification of telmisartan as a unique angiotensin Ⅱ receptor antagonist with selective PPARγ-modulating activity 显示文摘 | BENSON S C PERSHADSINGH H A HO C I | 2004 | Hypertension2004，43，5： | 1 |
| 4 | Short-term outcomes of 23-gauge pars plana vitrectomy显示文摘 | Gupta OP Ho A Kaiser PK Regillo C Chen S Dyer D | 2008 | Am J Ophthalmol2008，146，2： | 1 |
| 5 | Regulation of matrix metalloproteinases (MMP 2, 3, -9, and 13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption显示文摘 | Kusano K Miyaura C Inada M Tamura T ho A Nagase H | 1998 | Endocrinology1998，139，： | 1 |
| 6 | Identification of telmisartan as a unique angiotensin Ⅱ receptor antagonist with selective ppargamma- modulating activity 显示文摘 | Stephen C Benson Harrihar A Pershadsingh Christopher I Ho | 2004 | Hypertension2004，43，： | 1 |
| 7 | Modelling of springback in creepforming thick aluminum sheets 显示文摘 | Ho K C Lin J Dean T A | 2004 | International Journal ofPlasticity2004，20，： | 1 |
| 8 | Electrochemical sensor for multiplex screening of genetically modified DNA:Identification of biotech crops by logic-based biomolecular analysis显示文摘 | Liao W C Chuang M C Ho J A A | 2013 | Biosensors and Bioelectronics2013，50，15： | 1 |
| 9 | Aberrant activ- ation profile of cytokines and mitogen-activated protein kinases in type 2 diabetic patients with nephropathy 显示文摘 | WONG C K HO A W TONG P C | 2007 | Clin Exp Immunol2007，149，1： | 1 |
| 10 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 11 | Numerical calculation of particle transport in turbulent wall bounded flows powder technology显示文摘 | Sommerfeld M Ho C A | 2003 | Powder Technol2003，131，1： | 1 |
| 12 | Impact of Caregiving on Health and Quality of Life : A Comparative Popu- lation-based Study of Caregivers for Elderly Persons and Noncaregivers 显示文摘 | Ho S C Chan A Woo J Chong P and Sham A | 2009 | Journals of Gerontology Series A: Biologi- cal Sciences and Medical Sciences2009，64，： | 1 |
| 13 | Sensitivity and specificity of Epstein-Barr virus IGA titer in the diagnosis of nasopharyngeal carcinoma: a three-year institutional review 显示文摘 | Tsang R K Vlantis A C Ho R W | 2004 | Head Neck2004，26，7： | 1 |
| 14 | Estimating di- rections of arrival of completely and incompletely po- larized signals with electromagnetic vector sensors 显示文摘 | HO K C TAN K C NEHORAI A | 1999 | IEEE Trans Signal Process1999，47，10： | 1 |
| 15 | The natu- ral history of idiopathic subfoveal choroidal neovas- cularization显示文摘 | Ho A C YANN H A PISICANO K | 1995 | Ophthalmology1995，102，5： | 1 |
| 16 | Control and design of DC grids for offshore wind farms显示文摘 | Meyer C Hoing M Peterson A | 2007 | IEEE Transactions on Industry Applications2007，43，6： | 1 |
| 17 | Consideration of the role of guanxi in the ethical judgments of Chinese managers显示文摘 | Ho C Redfern K A | 2010 | Journal of Business Ethics2010，96，2： | 1 |
| 18 | A gradient technique for general buffer storage design in a production line显示文摘 | Ho Y C Eyler M A Chien T T | 1979 | Int J of Production Research1979，17，6： | 1 |
| 19 | Optimum diy eye classification using questionnaire responses显示文摘 | MCMONNIES C HO A WAKEFIELD D | 1998 | Adv Exp Med Biol1998，438，： | 1 |
| 20 | Characterization of biopolymeric flocculant (pectin) and organic synthetic flocculant (PAM): A comparative study on treatment and optimization in kaolin suspension 显示文摘 | Ho Y C Norli I Alkarkhi A F M | 2010 | Bioresource Technology2010，101，4： | 1 |
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