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| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | Development of ^(18)F-labeled radiotracers for neuroreceptor imaging with positron emission tomography显示文摘Positron emission tomography(PET)is an in vivo molecular imaging tool which is widely used in nuclear medicine for early diagnosis and treatment follow-up of many brain diseases.PET uses biomolecules as probes which are labeled with radionuclides of short half-lives,synthesized prior to the imaging studies.These probes are called radiotracers.Fluorine-18 is a radionuclide routinely used in the radiolabeling of neuroreceptor ligands for PET because of its favorable half-life of 109.8 min.The delivery of such radiotracers into the brain provides images of transport,metabolic,and neurotransmission processes on the molecular level.After a short introduction into the principles of PET,this review mainly focuses on the strategy of radiotracer development bridging from basic science to biomedical application.Successful radiotracer design as described here provides molecular probes which not only are useful for imaging of human brain diseases,but also allow molecular neuroreceptor imaging studies in various small-animal models of disease,including geneticallyengineered animals.Furthermore,they provide a powerful tool for in vivo pharmacology during the process of pre-clinical drug development to identify new drug targets,to investigate pathophysiology,to discover potential drug candidates,and to evaluate the pharmacokinetics and pharmacodynamics of drugs in vivo. | Peter Brust Jrg van den Hoff Jrg Steinbach | 2014 | Neuroscience Bulletin2014，30，5： | 3 |
| 3 | Extracts of human atherosclerotic lesions can modify low density lipoproteins leading to enhanced uptake by macropages显示文摘 | Hoff HF O Neil J | 1988 | Atherosclerosis1988，70，： | 2 |
| 4 | Evalution of CHAMP radio occultation refractivity using data assinzilation office analysis and radiosondes显示文摘 | Poli P Joiner J Hoff R M | 2003 | J Geophys Res Lett2003，30，15： | 1 |
| 5 | Analysis of chromosome 22markers in nine schizophrenia pedigrees 显示文摘 | Coon H Holik J Hoff M | 1994 | Am J Med Genet1994，54，1： | 1 |
| 6 | The importance of snow scavenging of polychlorinated biphenyl and polycyclic aromatic hydrocarbon vapors 显示文摘 | Wania F Mackay D Hoff J | 1999 | Environ Sci Technol1999，33，1： | 1 |
| 7 | The half-lives of uranium-234 and thorium-230显示文摘 | Cheng H Edwards R L Hoff J A | 2000 | Chem Geol2000，169，： | 1 |
| 8 | Detection of targets in terrain clutter by using muhispectral infrared image processing显示文摘 | HOFF L E EVANS J R BUNNEY L E | 1991 | SPIE1991，1481，： | 1 |
| 9 | Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats显示文摘 | Keep RF Hoff J T | 1998 | J Neurosurg1998，89，： | 1 |
| 10 | Tissue inhibitors of Metalloproteinases(TIMPs): their biological functions and involvement in oral disease显示文摘 | Verstappen J Von den Hoff JW | 2006 | J Dent Res2006，85，12： | 1 |
| 11 | Maximal strength improves work e- conomy in trained female cross country skiers显示文摘 | Hoff J Helgerud J | 1999 | Med Sci Sports Exerc1999，6，10： | 1 |
| 12 | Age and gender distributions of coronary artery calcium detected by electron beam tomography in 35126 adults显示文摘 | Hoff JA Chomka E Krainik A J | 2001 | Am J Cardiol2001，87，7： | 1 |
| 13 | Acute inflammatory reaction following experimental intracerebral hemorrhage in rat显示文摘 | Cong C Hoff J T Keep R F | 2000 | Brain Res2000，871，1： | 1 |
| 14 | Attentional Advice: Effects on Immediate, Delayed, and Transfer Task Performance显示文摘 | Foster J Hoff Macan T | 2002 | Human Performance2002，15，4： | 1 |
| 15 | Tissue inhibitors of metalloprotein- asses (TIMPs):their biological functions and involvement in oral disease 显示文摘 | Verstappen J Von flen Hoff JW | 2006 | J Dent Res2006，85，12： | 1 |
| 16 | The importance of snow scavenging of polycyclic aromatic hydrocarbon vapors 显示文摘 | WANIA F MACKAY D HOFF J T | 1998 | Environmental Science and Technology1998，33，： | 1 |
| 17 | Customing global marketing 显示文摘 | Quenlch J A Hoff E J | 1986 | Harvard Business Review1986，，56： | 1 |
| 18 | Variable immune response against a developmentally regulated Self-antigen显示文摘 | Stein hoff V Maloy K J Burkhart C | 1999 | J Auto immune1999，12，1： | 1 |
| 19 | Quantifying factors affecting sidewall air inlet performance 显示文摘 | Oberreuter M E Hoff S J | 2000 | Transactions of the ASAE2000，43，3： | 1 |
| 20 | Photobiology of micro-organisms: how photosensors catch a photon to initialize signaling 显示文摘 | Hellingwerf K J Hoff W D Crielaard W | 1996 | Mol Microbiol1996，21，： | 1 |
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