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| 1 | 光动力疗法治疗非小细胞肺癌显示文摘光动力疗法被越来越多地应用于治疗胸部恶性肿瘤。对于早期非小细胞肺癌(如支气管腔内肺癌)、X线检查阴性或同时性原发癌,光动疗法可作为主要治疗手段进行腔内根治性治疗。作为单一根治疗法,光动力疗法是治疗支气管镜可见≤1 cm且无软骨外浸润的肺部肿瘤的最有效方法。对于晚期非小细胞癌患者,光动力治疗可以作为综合根治疗法的一部分,用于减轻阻塞性支气管内病变,增加可手术性或缩小所需手术范围。本文对现有发表的应用光动力疗法治疗至少10例以上非小细胞肺癌病例的研究文献进行综述,提出了光动力疗法应用的治疗建议并进行了总结。 | Charles B Simone II Joseph S Friedberg Eli Glatstein James P Stevenson Daniel H Sterman Stephen M Hahn Keith A Cengel 袁光金 李金銮 朱宇熹 凌扬 | 2013 | 国际病理科学与临床杂志2013，33，3： | 3 |
| 2 | Involvement of donor T cell cytotoxic effector mechanisms in preventing allogeneic marrow graft rejection显示文摘 | Martin P Akatsuka Y Hahne M | 1998 | Blood1998，92，： | 2 |
| 3 | Effect of loading parameters on the fatigue behavior of impact damaged composite laminates 显示文摘 | Milan M Hahn H T Greg P C | 1999 | Composites Science and Technology1999，59，14： | 1 |
| 4 | Characterization of the inhibition of hepatitis C virus entry by in vitro-generated and patient-derived oxidized low-density lipoprotein显示文摘 | Westhaus S Bankwitz D Ernst S Rohrmann K Wappler I AgnéC Luchtefeld M Schieffer B Sarrazin C Manns M P Pietschmann T Ciesek S von Hahn T | 2013 | Hepatology2013，57，5： | 1 |
| 5 | S3-Leitlinie ?Exokrines Pankreaskarzinom” 2007显示文摘 | G Adler T Seufferlein S Bischoff H.-J Brambs S Feuerbach G Grabenbauer S Hahn V Heinemann W Hohenberger J Langrehr M Lutz O Micke H Neuhaus P Neuhaus H Oettle P Schlag R Schmid W Schmiegel K Schlottmann J Werner B Wiedenmann I Kopp | 2007 | Z Gastroenterol2007，，06： | 1 |
| 6 | Expression of cyclin D1 is correlated with poor prognosis in patients with areca quid chewing-related oral squamous cell carcinomas in Taiwan显示文摘 | KUO M Y P LIN C Y HAHN L J | 1999 | J Oral Pathol Med1999，28，4： | 1 |
| 7 | MR lymphangiogaphy for detection of minimal nodal disease in patients with prostate cancer 显示文摘 | HARISIANGI-IANI M G BARENTSZ J O HAHN P F | 2002 | Acad Rradiol2002，9，2： | 1 |
| 8 | Galeetin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death显示文摘 | Hahn H P Pang M He J | 2004 | Cell Death Differ2004，11，12： | 1 |
| 9 | Rapid Anodic Growth of TiO2 and WO3 Nanotubes in* Fluoride Free Electrolytes显示文摘 | HAHN R MACAK J M SCHMUKI P | 2007 | Electrochemistry Communications2007，9，5： | 1 |
| 10 | Vacuum-assisted breast biopsy: a comparison of 11-gauge and 8-gauge needles in benign breast disease显示文摘 | Hahn M Okamgba S Scheler P | 2008 | World J Surg Oncol2008，19，6： | 1 |
| 11 | Serum derived from multiple trauma patients promotes the differentiation of endothelial progenitor cells in vitro:possible role of transforming growth factor-betal and vascular endothelial growth factor165 显示文摘 | Henrich D Hahn P Wahl M | 2004 | Shock2004，21，1： | 1 |
| 12 | Benign and malignant ad- renal masses: CT distinction with attenuation coefficients, size, and observer analysis显示文摘 | Lee M J Hahn P F Papanicolaou N | 1991 | Radiology1991，179，2： | 1 |
| 13 | An in vitro assessment of the strength of porcelain veneers dependent on tooth preparation显示文摘 | Hahn P Gustav M Hellwig E | 2000 | J Oral Rehabil2000，27，12： | 1 |
| 14 | Different signalling pathways involving a Galpha protein, cAMP and a MAP kinase control germination of Botrytis cinerea conidia 显示文摘 | Doehlemann G Berndt P Hahn M | 2006 | Mol Microbiol2006，59，3： | 1 |
| 15 | Vacuum-assisted breast biop- sy : a comparison of 11-gauge and 8-gauge needles in benign breast disease显示文摘 | Hahn M Okamgba S Scheler P | 2008 | World journal of Surgical 0ncology2008，6，： | 1 |
| 16 | Use of Pi-5 (t) markers in marker assisted selection to screen for cultivars with resistance to Magnaporthe grisea 显示文摘 | Yi G Lee S K Hong Y K Cho Y C Nam M H Kim S C Han S S Wang G L Hahn T R Ronald P C Jeon J S | 2004 | Theoretical and Applied Genetics2004，109，5： | 1 |
| 17 | Noise triggering of radiation damping from the inverted state显示文摘 | Augustine M P Bush S D Hahn E L | 2000 | Chem Phys Lett2000，322，： | 1 |
| 18 | Research Low hemoglobin is as-sociated with poor functional outcome after non-traumatic, supraten-torial intracerebral hemorrhage 显示文摘 | Diedler J Sykora M Hahn P | 2010 | Critical Care2010，14，2： | 1 |
| 19 | Candidate colorectal cancer predisposing gene variants in Chinese early-onset and familial cases显示文摘AIM: To investigate whether whole-exome sequencing may serve as an efficient method to identify known or novel colorectal cancer(CRC) predisposing genes in early-onset or familial CRC cases.METHODS: We performed whole-exome sequencing in 23 Chinese patients from 21 families with nonpolyposis CRC diagnosed at ≤ 40 years of age, or from multiple affected CRC families with at least 1 firstdegree relative diagnosed with CRC at ≤ 55 years of age.Genomic DNA from blood was enriched for exome sequences using the Sure Select Human All Exon Kit, version 2(Agilent Technologies) and sequencing was performed on an Illumina Hi Seq 2000 platform.Data were processed through an analytical pipeline to search for rare germline variants in known or novel CRC predisposing genes.RESULTS: In total, 32 germline variants in 23 genes were identified and confirmed by Sanger sequencing.In 6 of the 21 families(29%), we identified 7 mutations in 3 known CRC predisposing genes including MLH1(5 patients), MSH2(1 patient), and MUTYH(biallelic, 1 patient), five of which were reported as pathogenic.Inthe remaining 15 families, we identified 20 rare and novel potentially deleterious variants in 19 genes, six of which were truncating mutations.One previously unreported variant identified in a conserved region of EIF2AK4(p.Glu738_Asp739insA rgA rg) was found to represent a local Chinese variant, which was significantly enriched in our early-onset CRC patient cohort compared to a control cohort of 100 healthy Chinese individuals scored negative by colonoscopy(33.3% vs 7%, P < 0.001).CONCLUSION: Whole-exome sequencing of early-onset or familial CRC cases serves as an efficient method to identify known and potential pathogenic variants in established and novel candidate CRC predisposing genes. | Jun-Xiao Zhang Lei Fu Richarda M de Voer Marc-Manuel Hahn Peng Jin Chen-Xi Lv Eugène TP Verwiel Marjolijn JL Ligtenberg Nicoline Hoogerbrugge Roland P Kuiper Jian-Qiu Sheng Ad Geurts van Kessel | 2015 | World Journal of Gastroenterology2015，21，14： | 1 |
| 20 | Bilateral operation of lumbar de- generative central spinal stenosis in full-endoscopic interlaminar technique with unilateral approach:prospective 2-year results of 74 patients显示文摘 | Komp M Hahn P Mark H | 2011 | J Spinal Disord Tech2011，24，5： | 1 |
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