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| 1 | Unexpected metastasis of intraductal papillary neoplasm of the bile duct without an invasive component to the brain and lungs:A case report显示文摘BACKGROUND Despite an expanding number of studies on intraductal papillary neoplasm of the bile duct(IPNB),distant metastasis remains unexplained especially in cases of carcinoma in situ.In the present study,we report a rare and interesting case of IPNB without invasive components that later metastasized to lungs and brain.CASE SUMMARY A 69-year-old male was referred to our hospital due to suspected cholangiocarcinoma.Laboratory tests on admission reported a mild elevation of alkaline phosphatase,γ-glutamyl transpeptidase,and total bilirubin in serum.Endoscopic retrograde cholangiography revealed a filling defect in the common bile duct(CBD)extending to the left hepatic duct.Peroral cholangioscopy delineated a tumor in the CBD that had a papillary pattern.Multidetector computed tomography and magnetic resonance cholangiopancreatography detected partial blockage ot interlude in the CBD leading to cholestasis without evidence of metastasis.Therefore,a diagnosis of IPNB cT1N0M0 was established.Left hepatectomy with bile duct reconstruction was performed.Pathological examination confirmed an intraepithelial neoplasia pattern without an invasive component and an R0 resection achievement.The patient was monitored carefully by regular examinations.However,at 32 mo after the operation,a 26 mm tumor in the lungs and a 12 mm lesion in the brain were detected following a suspicious elevated CA 19-9 level.Video-assisted thoracoscopic surgery of left upper lobectomy and stereotactic radiotherapy are indicated.In addition to histopathological results,a genomic profiling analysis using whole exome sequencing subsequently confirmed lung metastasis originating from bile duct cancer.CONCLUSION This case highlights the important role of genomic profiling analysis using whole exome sequencing in identifying the origin of metastasis in patients with IPNB. | Nguyen Hai Nam Kojiro Taura Masashi Kanai Keita Fukuyama Norimitsu Uza Hirona Maeda Yojiro Yutaka Toyofumi F Chen-Yoshikawa Manabu Muto Shinji Uemoto | 2020 | World Journal of Gastroenterology2020，26，3： | 5 |
| 2 | Hybrid treatment systems for dye wastewater显示文摘 | Hai F I Yamamoto K Fukushi K | 2007 | Critical Reviews in Environmental Science and Technology2007，37，4： | 1 |
| 3 | Quality of life with special re- spect to depression after surgical treatment of hypertensive ba- salganglia hemorrhage显示文摘 | Hai J Zhanq L Wang F | 2010 | Neurol India2010，58，1： | 1 |
| 4 | Influ- enza viruses expressing chimeric hemagglutinins: Globu- lar head and stalk domains derived from different sub- types 显示文摘 | Hai R Krammer F Tan G S Pica N Eggink D Maamary J Margine I Albrecht R A Palese P | 2012 | J Virol2012，86，10： | 1 |
| 5 | Patient education integrated with acupuncture for relief of can- cer-related fatigue randomized controlled feasibility study 显示文摘 | Johnston M F Hays R D Subramanian S K | 2011 | Bmc Complementary and Alternative Medicine2011，11，： | 1 |
| 6 | Role for molecular chaperones in protein degradation显示文摘 | Hays SA Dice J F | 1996 | J Cell Biol1996，132，3： | 1 |
| 7 | H3n2 influenza vi- rus infection induces broadly reactive hemagglutinin stalk antibodies in humans and mice 显示文摘 | Margine I Hai R Albrecht R A Obermoser G Har-rod A C Banchereau J Palucka K Garcia-Sastre A Palese P Treanor J J Krammer F | 2013 | J Virol2013，87，8： | 1 |
| 8 | Preconditioned hyperbaric oxygenation protects skin flap grafts in rats against ischemia/ reperfusion injury显示文摘 | Kang N Hai Y Liang F | 2014 | Mol Med Rep2014，9，： | 1 |
| 9 | Artificial molecular quantum rings: Spin densityfunctional theory calculations 显示文摘 | Castelano L K Hai G-Q Partoens B Peeters F M | 2006 | Phys Rev B2006，74，04： | 1 |
| 10 | WWF as non-structural slab reinforcement显示文摘 | Hays C D Fibers vs | 1991 | Concrete International1991，13，： | 1 |
| 11 | Markov chain monte carlo algorithms for CDMA and MIMO communication systems 显示文摘 | BEHROUZ F B ZHU Hai Dong SHI Zhen Ning | 2006 | IEEE Transactions of signal processing2006，54，5： | 1 |
| 12 | Kinetics of crystal growth from silicate melts: Diopside and anorthite显示文摘 | Kirkpatrik C R Robinson G P Hays J F | 1975 | Geo- logical Society of America Abstracts with Programs1975，7，： | 1 |
| 13 | Removal of micropollutants by membrane bioreactor under temperature variation显示文摘 | HAI F I TESSMER K NCUYEN L N | 2011 | J Membr Sci2011，383，： | 1 |
| 14 | Quality of life with special re- spect to depression after surgical treatment of hypertensive basal ganglia hemorrhage显示文摘 | Hai J Zhang L Wang F | 2010 | Neurol India2010，58，1： | 1 |
| 15 | On performance of sphere decoding and markov chain monte carlo detection methods显示文摘 | ZHU Hai Dong BOROUJENY B F CHEN Rong Rong | 2005 | Signal Processing Letters IEEE2005，12，10： | 1 |
| 16 | The pre-treatment effect on brain injury during restoration of normal perfusion pressure with hemodilution in a new rat model of chronic cerebral hypoperfusion 显示文摘 | Hai J Lin Q Deng D F | 2007 | Neural Res2007，29，6： | 1 |
| 17 | Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses显示文摘 | Pica N Hai R Krammer F et aI | 2012 | Proc Natl Acad Sci U S A2012，109，7： | 1 |
| 18 | Modifying the surface of electrically conductive porous alumina显示文摘 | HAI C X WATANABE H SHIRAI T FUJI M TAKAHASHI M WANG F | 2009 | Materials Letters2009，63，15： | 1 |
| 19 | Hologen Bonds in Biological Molecules:Proc Nat显示文摘 | AUFFINGER P HAYS F A WESTHOF E | 2004 | Acad Sci2004，101，16： | 1 |
| 20 | Sludge cycling between aerobic,anoxic and anaerobic regimes to reduce sludge production during wastewater treatment:Performance,mechanisms,and implications显示文摘 | Semblante G U Hai F I Ngo H H | 2014 | Bioresource Technology2014，155，： | 1 |
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