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520篇 您的检索式:作者名="Hamilton J S"
    题名 作者 年代 出处 被引量
1Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD.Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele 2009World Journal of Gastroenterology2009,15,10:20
2Reconstructing the Primordial Spectrum of Fluctuations of the Universe from the Observed Nonlinear Clustering of Galaxies显示文摘Hamilton A J S Kumer P Lu E 1991ApJ1991,374,:3
3An integrated anal ytical approach for determining the origin of solid bitumens in the McArthur Basin,Northern Australia显示文摘George S C Llorca S M Hamilton P J 1994Org Geochem1994,21,:1
4Physical modeling of the step recovery diode for pulse and harmonic generation circuits显示文摘Moll J L Hamilton S A 1969Proc of the IEEE1969,57,7:1
5C-2 neurec-tomy during atlantoaxial instrumented fusion in the elderly: patient satisfaction and surgical outcome 显示文摘Hamilton D K Smith J S Sansur C A 2011J Neurosurg Spine2011,15,1:1
6Effect of pH on glucose and starch fermentation in batch and sequenced batch mode with a recently isolated strain of hydrogen-producing Clostridium butyricum CWBI1009 显示文摘Masset J Hiligsmann S Hamilton C 2010International Journal of Hydrogen Energy2010,35,8:1
7ASCO 2006 update of recom- mendations for the use of tumor markers in gastrointestinal cancer显示文摘Locker GY Hamilton S Harris J 2006J Clini Oncol2006,24,33:1
8The effect of published reports of unethical conduct on stock prices显示文摘RAO S M HAMILTON J B 1996Journal of Business Ethics1996,,12:1
9Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R 2009Journal of Bacteriology2009,191,16:1
10Feline ilial fractures:a prospective study of dorsal plating and comparisonwith lateral plating显示文摘Langley-Hobbs S J Meeson R L Hamilton M H 2009Vet Surg2009,38,:1
11The production and emission of nitrous oxide from headwater streams in the midwestern United States显示文摘Beaulieu J J Arango C P Hamilton S K 2008Global Change Biology2008,14,4:1
12Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis显示文摘Creticos P S Schroeder J T Hamilton R G 2006N Engl J Med2006,355,:1
13Births: final data for 2001 显示文摘Martin JA Hamilton BE Ventura S J 2002National Statistics Report2002,51,2:1
14Comprehensive wealth and future consumption: Accounting for population growth 显示文摘Ferreira S Hamilton K Vincent J 2008World Bank Economic Review2008,22,2:1
15In vivo targeting of malignant melanomas by 125Iodine-and 99mTechnetium-labeled ScFv fragments against high molecular weight melanoma-associated antigen显示文摘Kang N Hamilton S Odili J 2000Clin cancer Res2000,6,12:1
16Dislocation nucleation and defect structure during surface indentation 显示文摘Kelchner C L Plimpton S J Hamilton J C 1998Phys Rev B1998,58,11:1
17Therapeutic regulation of endothelial dysfunction in type 2 diabetes mellitus 显示文摘Chew G T Hamilton S J Watts G F 2007Diabet Vase Res2007,4,:1
18Feline ilial fractures:assessment of screw loosening and pelvic canal narrowingafter lateral plating显示文摘Hamilton M H Evans D A Langley-Hobbs S J 2009Vet Surg2009,38,:1
19Cell surface regulation ofsilica-induced apoptosis by the SR-A scavenger receptor in a murinelung macrophage cell line ( MH-S) 显示文摘Chao S K Hamilton R F Pfau J C 2001Toxicol Appl Pharmacol2001,,:1
20Refractory clostridium difficile-associated diarrhea 显示文摘Grover S Hamilton M J Carr-locke DL 2007Med Gen Med2007,9,2:1
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