|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 2 | The elastic compensation method for limit and shakedown analysis:a review显示文摘 | D Mackenzie J T Boyle R Hamilton | 2000 | Journal of Strain Analysis2000，35，3： | 1 |
| 3 | Natural occurrences of ochratoxicosis in poultry显示文摘 | Hamilton P A T B Huff W E Harris J R A Y | 1982 | Poultry Science1982，61，9： | 1 |
| 4 | Simplified lower bound limit analysis of pressurized cylinder/cylinder intersections using generalized yield criteria显示文摘 | R Hamilton D Mackenzie J Shi J T Boyle | 1996 | Int J Pres Ves and Piping1996，67，2： | 1 |
| 5 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 6 | Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis显示文摘 | Creticos P S Schroeder J T Hamilton R G | 2006 | N Engl J Med2006，355，： | 1 |
| 7 | Therapeutic regulation of endothelial dysfunction in type 2 diabetes mellitus 显示文摘 | Chew G T Hamilton S J Watts G F | 2007 | Diabet Vase Res2007，4，： | 1 |
| 8 | Exercise,antioxidants,and HSP72:protection against myocardial ischemia/reperfusion显示文摘 | Hamilton K L Staib J L Phillips T | 2003 | Free Radic Biol Med2003，34，7： | 1 |
| 9 | A new mineralized layer in the hinge of the oyster显示文摘 | Skipper J K Hamilton T H | 1979 | Science1979，206，9： | 1 |
| 10 | The elastic compensation method for limit and shakedown analysis: a review显示文摘 | MACKENZIE D BOYLE J T HAMILTON R | 2000 | Journal of Strain Analysis2000，35，3： | 1 |
| 11 | Simulation of soil-blade interaction for sandy soil using advanced 3D finite element analysis显示文摘 | Abo-Elnor M Hamilton R Boyle J T | 2004 | Soil and Tillage Research2004，75，： | 1 |
| 12 | Immunohistochemical markers for basementmembrane proteins and proliferation and apoptosis markers in sulfur mustard inducedcutaneous lesions in weanling pigs显示文摘 | Smith KJ Graham J Hamilton T | 1997 | J Dermatol Sci1997，15，： | 1 |
| 13 | Revascularization and aneurysm surgery:,current techniques,indications,and outcome显示文摘 | HAMILTON M G MORCOS J J | 1996 | Neurosurgery1996，38，1： | 1 |
| 14 | Granulocyte-macrophage colony-stimulating factor(CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles end transcription factor activities:implications for CSF blockade in inflam- mation显示文摘 | Fleetwood A J Lawrence T Hamilton JA et a 1 | 2007 | J Immunol2007，178，8： | 1 |
| 15 | Prevalence of psychotropic medication use among cosmetic and medical dermatology patients:A comparative study显示文摘 | Orringer J Helfrich Y Hamilton T | 2006 | J Am Acad Dermatol2006，54，3： | 1 |
| 16 | LPS induces altered phosphate labeling of proteins in murine peritoneal macrophages显示文摘 | WEIEL J E HAMILTON T A ADAMS D O | 1986 | J Immunol1986，136，8： | 1 |
| 17 | New spontaneous fission mode for 252Cf显示文摘 | TER-AKOPIAN G M HAMILTON J H OGANESSIAN Y T | 1996 | Physics Review Letter1996，77，： | 1 |
| 18 | Methoxyl groups of plant pectin as a precursor of atmospheric methane:Evidence from deuterium labelling studies显示文摘 | Keppler F Hamilton J T G McRoberts W C | | 0，，04： | 1 |
| 19 | mVps34 is activated following high-resistance contractions显示文摘 | MACKENZIE M G HAMILTON D L MURRAY J T | 2009 | J Physiol2009，587，1： | 1 |
| 20 | Irradiation detection 显示文摘 | Stevenson M H Crone A V J Hamilton J T G | 1990 | Nature1990，344，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员