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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | REACH:Clinicalfeasibility of a rural telestroke network显示文摘 | Hess DC Wang S Hamilton W | 2005 | Stroke2005，36，： | 1 |
| 3 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 4 | Brillouin scattering measurement on optical glasses显示文摘 | Heiman D Hamilton D S Hellwarth R W | 1979 | Phy Rev B1979，19，12： | 1 |
| 5 | On Quaternions or on a New System of Imaginaries in Algebra显示文摘 | Hamilton S W R | 2009 | Philosophical Magazine2009，29，191： | 1 |
| 6 | 显示文摘 | Raich W J Hamilton C S | 1957 | J Am Chem Soc1957，79，： | 1 |
| 7 | The mechanical properties of 316L/304L stainless steels, Alloy 718 and Mod 9Cr-1Mo after irradiation in a spallation environment 显示文摘 | Maloy S A James M R Willcutt G Sommer W F Sokolov M Snead L L Hamilton M L Garner F | 2001 | Journal of Nuclear Material2001，296，： | 1 |
| 8 | REACH:Clinical feasibility of a rural telestroke network显示文摘 | Hess DC Wang S Hamilton W | 2005 | Stroke2005，36，： | 1 |
| 9 | Multiscale modeling for the prediction of casting defects in investment cast aluminum alloys显示文摘 | Hamilton R W See D Butler S | 2003 | Materials Science and Engineering2003，343，： | 1 |
| 10 | The TIGR Rice genome annotation resource: improvements and new fea-tures 显示文摘 | Ouyang S Zhu W Hamilton J | 2007 | Nucleic Acids Research2007，35，： | 1 |
| 11 | Predicting invasions of woody plants introduced into North America显示文摘 | REICHARD S H HAMILTON C W | 1997 | Conservation Biology1997，11，1： | 1 |
| 12 | Multiscale Modeling for the Prediction of Casting Defects in Investment Cast Aluminum Alloys显示文摘 | R W Hamilton D See S Butler | 2003 | Materials Science and Engineering A2003，，343： | 1 |
| 13 | Multiplex real-time SYBR Green Ⅰ PCR assay for detection of tetracycline efflux genes of Gram-negative bacteria显示文摘 | FAN W HAMILTON T WEBSTER-SESAY S | 2007 | Mol Cell Probes2007，21，4： | 1 |
| 14 | Isolation and characterization of a cyclic hydroxamate from Zea mays显示文摘 | Hamilton R H Bandurski R S Reusch W H | | 0，，： | 1 |
| 15 | Force on a sphere accelerating in viscous fluid 显示文摘 | ODAR F HAMILTON W S | 1964 | J Fluid Mech1964，18，： | 1 |
| 16 | Stable carbon and nitrogen isotopes in algae and detritus from the Orinoco River floodplain, Venezuela 显示文摘 | Hamilton S K Lewis Jr W M | 1992 | Geochimica et Cosmochimica Acta1992，56，： | 1 |
| 17 | The magnitude of random errors in acoustic rhinometry and re-interpretation of the acoustic profile显示文摘 | Hamilton J W McRae R D R Jones A S | 1997 | Clin Otolaryngol1997，22，： | 1 |
| 18 | Spontaneous improvement in late rectal mucosal changes after radiotherapy for prostate cancer显示文摘 | Peter C O’Brien Christopher S Hamilton James W Denham Ralph Gourlay C.Ian V Franklin | 2004 | International Journal of Radiation Oncology, Biology, Physics2004，，1： | 1 |
| 19 | Quantitative investigation of QRS detection rules using the MIT/BIH arrhythmia database显示文摘 | HAMILTON P S TOMPKINGS W J | 1986 | IEEE Transactions on Biomedical Engineering1986，33，12： | 1 |
| 20 | Multiscale modeling for the prediction of casting defects in investment cast aluminum alloys显示文摘 | Hamilton R W See D Butler S | 2003 | Materials Science&Engineering A2003，343，12： | 1 |
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