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| 1 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 2 | Role for a bidentate ribonuclease in the initiation step of RNA interference显示文摘 | Bernstein E Caudy A A Hammond S M | 2001 | Nature2001，409，6818： | 2 |
| 3 | Argonaute2,a link between genetic and biochemical analyses of RNAi显示文摘 | Hammond SM Boettcher S Caudy AA | 2001 | Science2001，293，： | 1 |
| 4 | Argonaute2,a link between genetic and biochemical analyses of RNAi 显示文摘 | Boettcher S Caudy AA | 2001 | Science2001，293，： | 1 |
| 5 | Characterization of neogenin-expressing neural progenitor populations and migrating neuroblasts in the embryonic mouse forebrain显示文摘 | Fitzgerald D P Cole S J Hammond A | 2006 | Neuroscience2006，142，3： | 1 |
| 6 | An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells显示文摘 | Hammond S M Bernstein E Beach D | 2000 | Nature2000，404，： | 1 |
| 7 | Role for a bidentate ribonuclease in the initiation step of RNA interference显示文摘 | Bernstein E Caudy A A Hammond S M | 2001 | Nature2001，409，： | 1 |
| 8 | Role for a bidentate ribonuclease in the initiation step of RNA interference显示文摘 | Bernstein E Caudy AA Hammond S | 2001 | Nature2001，409，： | 1 |
| 9 | Tracking Spore-Forming Bacterial Contaminants in Fluid Milk-Processing Sys- tems 显示文摘 | HUCK J R HAMMOND B H MURPHY S C | 2007 | Journal of Dairy Science2007，90，： | 1 |
| 10 | Role for a bidentate ribonuclease in the initiation step of RNA interfer- ence显示文摘 | Bernstein E Caudy A A Hammond S M | 2001 | Nature2001，409，： | 1 |
| 11 | Crystal structures and properties of nylon polymers from theory 显示文摘 | DASGUPTA S HAMMOND W B GODDARD W A | 1996 | Journal of the American Chemical Society1996，11，12： | 1 |
| 12 | Role for a bidentate ribonuclease in the initiation step of RNA interference显示文摘 | CAUDY A A HAMMOND S M | 2001 | Nature2001，409，6818： | 1 |
| 13 | Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors 显示文摘 | Woods K Thomson J M Hammond S M | 2007 | J Biol Chem2007，282，4： | 1 |
| 14 | Role for a Bidentate Ribonuclease in the Initiation Step of RNA Interfer- ence 显示文摘 | BERNSTEIN E CAUDY A HAMMOND S | 2001 | Nature2001，409，6818： | 1 |
| 15 | Worker exposure to volatile organic compounds in the vehicle repair industry 显示文摘 | Wilson M P Hammond S K Nicas M | 2007 | J Oc- cup Environ Hyg2007，4，5： | 1 |
| 16 | An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosop cells显示文摘 | Hammond S M Bernstein E Beach D | 2000 | Nature2000，404，： | 1 |
| 17 | Post-transcriptional gene silencing by double-stranded RNA显示文摘 | HAMMOND S M CAUDY A A | 2001 | Nat Rev Genet2001，2，2： | 1 |
| 18 | Concentrations and potential health risks of metals in lip products显示文摘 | Liu S Hammond SK Rojas-Cheatham A | 2013 | Environm Health Perspec2013，121，6： | 1 |
| 19 | Membrane- based extractive fermentation to produce propionic and acetic adds: toxiciw and mass transfer considerations显示文摘 | Solichien M S O' Brien D Hammond E G | 1995 | Enzyme Microb Technol1995，17，： | 1 |
| 20 | An RNA- directed nuclease mediates post-transcriptional gene silencing in Drosophia cells 显示文摘 | Hammond S M Benstein E Beach D | 2000 | Nature2000，404，6775： | 1 |
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