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| 1 | Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis显示文摘AIM:To investigate the association of macrophage migration inhibitory factor(MIF)promoter polymorphisms with inflammatory bowel disease(IBD)risk.METHODS:One thousand and six New Zealand Caucasian cases and 540 Caucasian controls were genotyped for the MIF SNP-173G>C(rs755622)and the repeat polymorphism CATT5-8(rs5844572)using a predesigned TaqMan SNP assay and capillary electrophoresis,respectively.Data were analysed for single site and haplotype association with IBD risk and phenotype.Meta-analysis was employed,to assess cumulative evidence of association of MIF-173G>C with IBD.All published genotype data for MIF-173G>C in IBD were identified using PubMed and subsequently searching the references of all PubMed-identified studies.Imputed genotypes for MIF-173G>C were generated from the Wellcome Trust Case Control Consortium(and National Institute of Diabetes and Digestive and Kidney Diseases).Separate meta-analyses were performed on Caucasian Crohn’s disease(CD)(3863 patients,6031controls),Caucasian ulcerative colitis(UC)(1260 patients,1987 controls),and East Asian UC(416 patients and 789 controls)datasets using the Mantel-Haenszel method.The New Zealand dataset had 93%power,and the meta-analyses had 100%power to detect an effect size of OR=1.40 atα=0.05,respectively.RESULTS:In our New Zealand dataset,single-site analysis found no evidence of association of MIF polymorphisms with overall risk of CD,UC,and IBD or disease phenotype(all P values>0.05).Haplotype analysis found the CATT5/-173C haplotype occurred at a higher frequency in New Zealand controls compared to IBD patients(0.6 vs 0.01;P=0.03,OR=0.22;95%CI:0.05-0.99),but this association did not survive bonferroni correction.Meta-analysis of our New Zealand MIF-173G>C data with data from seven additional Caucasian datasets using a random effects model found no association of MIF polymorphisms with CD,UC,or overall IBD.Similarly,meta-analysis of all published MIF-173G>C data from East Asian datasets(416UC patients,789 controls)found no association of this promoter polymorphism with UC. | James D Falvey Robert W Bentley Tony R Merriman Mark B Hampton Murray L Barclay Richard B Gearry Rebecca L Roberts | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | OxLDL induced cell death is inhibited by the macrophage synthesised pterin,7,8-dihydroneopterin,in U937 cells but not THP-1 cells显示文摘 | BAIRD S K REID L HAMPTON M B | 2005 | Biochem Biophys Acta2005，1745，： | 1 |
| 3 | Partial discharge diagnostics for gas insulated substation显示文摘 | PEARSON J S FARISH O HAMPTON B F | 1995 | IEEE Transactions on Dielectrics and Electrical Insulation1995，2，5： | 1 |
| 4 | Diagnostic measurenment at UHF in gas insulated substations显示文摘 | HAMPTON B F MEATS R J | 1988 | IEE Proceedings1988，135，2： | 1 |
| 5 | Partial discharge diagnostics for gas insulated substations显示文摘 | PEARSON J S FARISH O HAMPTON B F | 1995 | IEEE Transaction on Dielectrics and Electrical Insulation1995，2，2： | 1 |
| 6 | The excitation of UHF signals by partial discharges in GIS显示文摘 | JUDD M D FARISH O HAMPTON B F | 1996 | IEEE Transactions on Dielectrics and Electrical Insulation1996，3，2： | 1 |
| 7 | Redox regulation of apoptotic cell death显示文摘 | Orrenius S | 1998 | Biofactors1998，8，12： | 1 |
| 8 | Excitation of UHF signals by partial discharge in GIS显示文摘 | Judd M D Farish O Hampton B F | 1996 | IEEE Trans on Dielectrics and Electrical Insulation1996，3，2： | 1 |
| 9 | The excitation of UHF signals by partial discharges in GIS显示文摘 | JUDD M D FARISH O HAMPTON B F | 1996 | IEEE Transactions on Dielectrics and Electrical Insulation1996，3，2： | 1 |
| 10 | Serum antibody levels to three food antigens in atopic and non-atopic subjects 显示文摘 | Hampton S M Morgan J B | 1992 | Int J Food Sci Nutr1992，43，： | 1 |
| 11 | The excitation of UHF signals by partial discharge in GIS显示文摘 | Judd M D Farish O Hampton B F | 1996 | IEEE Trans on Dielectrics and Electrical Insulation1996，3，2： | 1 |
| 12 | Partial discharge diagnostics for gas insulated substations显示文摘 | Pearson J S Farish O Hampton B F | 1995 | IEEE Trans on Dielectrics and Electrical Insulation1995，2，5： | 1 |
| 13 | Androgen receptor mRNA expression in the bovine ovary显示文摘 | Hampton J H Manikkam M Lubahn D B | 2004 | Domestic Animal Endoerinol2004，27，1： | 1 |
| 14 | Using the UHF technique to investigate PD produced by defects in solid insulation显示文摘 | Selllars A G Farish O Hampton B F | 1995 | IEEE Trans on Dielectrics and Electrical Insulation1995，2，3： | 1 |
| 15 | Living Networked on and off Line显示文摘 | WELLMAN B HAMPTON K | 1999 | Contemporary Sociology1999，28，6： | 1 |
| 16 | Partial discharge diagnostics for gas insulated substations 显示文摘 | Pearson J S Farish O Hampton B F | 1995 | IEEE Transactions on Dielectrics and Electrical Insulation1995，2，5： | 1 |
| 17 | The Excitation of UHF Signals by Partial Discharges in GIS 显示文摘 | JUDD M D FARISH O HAMPTON B F | 1996 | IEEE Transactions on Dielectrics and Electrical Insulation1996，3，2： | 1 |
| 18 | Charity-based voluntourism versus lifestyle voluntourism: Evidence from Nicaragua and Malaysia 显示文摘 | Daldeniz B Hampton M | 2010 | Working pappers :Kent Business School2010，，： | 1 |
| 19 | Diagnostic Measurements at UHF in Gas Insu- lated Substation显示文摘 | Hampton B F Meats R J | 1998 | IEEE Proceedings1998，135，2： | 1 |
| 20 | Inside the neutrophil phagosome : oxidants, myeloperoxidase and bacterial killing 显示文摘 | Hampton M B Kettle A J Winterbourn C C | 1998 | Blood1998，92，9： | 1 |
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