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| 1 | Three-dimensional human facial morphologies as robust aging markers显示文摘老化与许多复杂疾病被联系。变老的过程的可靠预言为估计联系老化的疾病的风险是重要的。然而尽管有强烈研究,到目前为止没有可靠老化标记。这里,我们由检验人的 3D 美容成像特征是否能被用作可靠老化标记处理了这个问题。我们收集了 >300 幅 3D 人美容图象和越过 17 ~ 77 年的年龄散布得好的血侧面。由分析词法侧面,我们产生了变老的人的面部 phenome 的第一张全面地图。我们鉴别量的面部特征例如眼睛斜坡,高度与年龄联系了。我们构造了一个柔韧的年龄预言者并且发现平均,一样的按年代先后的年龄的人由 ± 不同;在美容的 6 年变老,与在年龄 40 以后增加的偏差。用这个预言者,我们识别了被健康指示物的层次显著地支持的慢、快的蒸化机。尽管有在在血的面部词法特征和健康指示物之间的一种靠近的关系,面部特征比血侧面是更可靠的老化 biomarkers 并且能更好比按年代先后的年龄反映一般健康地位。 | Weiyang Chen Wei Qian Gang Wu Weizhong Chen Bo Xian Xingwei Chen Yaqiang Cao Christopher D Green Fanghong Zhao Kun Tang Jing-Dong J Han | 2015 | Cell Research2015，25，5： | 17 |
| 2 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 3 | Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial显示文摘 | Geert D’Haens Filip Baert Gert van Assche Philip Caenepeel Philippe Vergauwe Hans Tuynman Martine De Vos Sander van Deventer Larry Stitt Allan Donner Severine Vermeire Frank J Van De Mierop Jean-Charles R Coche Janneke van der Woude Thomas Ochsenkühn Ad A | 2008 | The Lancet2008，，9613： | 5 |
| 4 | 残余应力导致三层聚烯烃管道防腐层剥离与开裂显示文摘这是美国运输部发起的研究项目,一个管道防腐层专家团队参与了本研究项目,评价了三层聚烯烃管道外防腐涂层(3LPO)的完整性。研究表明,三层聚烯烃管道外防腐涂层(3LPO)存在剥离和面层开裂两大完整性问题。过去几年里,据文献报道,三层聚烯烃管道外防腐涂层(3LPO)的熔结环氧粉末(FBE)底漆与钢管界面上发生多起防腐层剥离事故,以及聚丙烯(PP)面层发生开裂事故。这些防腐层事故引起人们对使用三层聚烯烃管道外防腐涂层(3LPO)的关注。一般来讲,三层聚烯烃管道外防腐涂层(3LPO)采用比较厚的聚烯烃面层增强防腐层抗机械损伤和防止水渗透的能力。但是,聚烯烃的热膨胀系数比钢材高得多,结果在防腐层系统里产生比较高的残余热应力。因为残余应力高,造成防腐层剥离,尤其在管端截短防腐层和任何防腐层的边上,因为这些是高应力集中部位。特别是假如钢管表面预处理不当,就无法保证防腐层持久达到很强的粘合强度。如果熔结环氧粉末(FBE)底漆配方选择不当,发生热氧化降解,也导致防腐层过早失效。如果使用温度很高,聚丙烯也会因为热氧化降解而变脆。在残余应力下,这样脆性的聚丙烯面层就会开裂。本文分析了三层聚烯烃管道外防腐涂层(3LPO)中的残余应力,并且探讨了残余应力对三层聚烯烃管道外防腐涂层(3LPO)剥离和聚丙烯(PP)面层开裂机理的影响。 | B.T.A.Cheng S Hung-jue J Han D Wong A Kehr M Mallozzi F Aguirre H Pham W Snider 王向农(译) | 2011 | 防腐保温技术2011，19，3： | 3 |
| 5 | Characterization of the humoral and cellular immune responses against hepatitis C virus core induced by DNA-based immunization显示文摘 | Hu G J Wang R Y Han D S | 1999 | Vaccine1999，17，2324： | 2 |
| 6 | Expression of type IV collagen in psammoma bodies: inmlunofluoreseence studies on two fresh human meningiomas显示文摘 | Han J Daniel J C Pappas G D | 1996 | Acta Cytologica1996，40，2： | 1 |
| 7 | A Set of Standard Modeling Commands for the History - Based Parametric Approach 显示文摘 | D Mun S Han J Kim | 2003 | Computer - Aided Design2003，35，13： | 1 |
| 8 | Head and backbone of the Early Cambrian vertebrate Haikouichthys显示文摘 | SHU D CONWAY M S HAN J | 2003 | Nature2003，421，： | 1 |
| 9 | Fe-Mn martensitic alloys for control of noise and vibration in engineering applications 显示文摘 | Balk S H Kim J C Han D W etal | 2006 | Materials Science and Engineering A2006，，： | 1 |
| 10 | Laboratory and pilot-scale study on dehydration of benzene by pervapo ration显示文摘 | Li J D Chen C X Han B B | 2002 | J Member Sci2002，203，12： | 1 |
| 11 | Production by Aspegillus ficuum on semisolid substrate 显示文摘 | HAN Y W GALLAGHER D J WILFED A G | 1987 | Journal of Industrial Microbiology1987，2，： | 1 |
| 12 | Network-based robust H∞ control of systems with uncertainty显示文摘 | YUE D HAN Q L LAM J | 2005 | Automatica2005，41，6： | 1 |
| 13 | The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population显示文摘 | Wang A H Lam W J Han D Y | 2011 | Human Immunology2011，72，： | 1 |
| 14 | Adaptations to environmental stresses显示文摘 | Hans J Bohnert Nelson D E Jensen R G | 1995 | Plant cell1995，7，： | 1 |
| 15 | Automatic Generation of Ladder Diagram with Control Petri Net 显示文摘 | LEE G B HAN Z D LEE J S | 2004 | Journal of Intelligent Manufacturing2004，15，： | 1 |
| 16 | Remote measurement of algal chlorophyll in surface waters:the case for the first derivative of reflectance near 690nm显示文摘 | Rundquitst D C Han L Schalles J F | 1996 | Photogramm Eng Remote Sens1996，62，： | 1 |
| 17 | Prevalence,Capsular Type and Antimicrobial Susceptibility of Streptococcus suis Isolated from Slaughter Pigs in Korea显示文摘 | Han D U Choi C Ham H J | 2001 | Can J Vet Res2001，65，3： | 1 |
| 18 | A set of standard modeling commands for the history-based parametric approach显示文摘 | Mun D Han S Kim J | 2003 | Computer-Aided Design2003，35，13： | 1 |
| 19 | Effect of gas bubbling and impeller agitation on degassing kinetics during magnesium alloy (AZ91D) melt recycling-water model approach 显示文摘 | Han J W Kim D J You B D | 2003 | Materials Science Forum2003，439，： | 1 |
| 20 | Design of high power permanent magnet motor with segment rectangular copper wire and closed slot opening on electric vehicles显示文摘 | Choi J H Chtm Y D Han P W | 2010 | IEEE Transactions on Magnetics2010，46，6： | 1 |
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