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| 1 | Pancreaticβ-cell dysfunction in type 2 diabetes:Implications of inflammation and oxidative stress显示文摘Insulin resistance and pancreaticβ-cell dysfunction are major pathological mechanisms implicated in the development and progression of type 2 diabetes(T2D).Beyond the detrimental effects of insulin resistance,inflammation and oxidative stress have emerged as critical features of T2D that defineβ-cell dysfunction.Predominant markers of inflammation such as C-reactive protein,tumor necrosis factor alpha,and interleukin-1βare consistently associated withβ-cell failure in preclinical models and in people with T2D.Similarly,important markers of oxidative stress,such as increased reactive oxygen species and depleted intracellular antioxidants,are consistent with pancreaticβ-cell damage in conditions of T2D.Such effects illustrate a pathological relationship between an abnormal inflammatory response and generation of oxidative stress during the progression of T2D.The current review explores preclinical and clinical research on the pathological implications of inflammation and oxidative stress during the development ofβ-cell dysfunction in T2D.Moreover,important molecular mechanisms and relevant biomarkers involved in this process are discussed to divulge a pathological link between inflammation and oxidative stress duringβ-cell failure in T2D.Underpinning the clinical relevance of the review,a systematic analysis of evidence from randomized controlled trials is covered,on the potential therapeutic effects of some commonly used antidiabetic agents in modulating inflammatory makers to improveβ-cell function. | Phiwayinkosi V Dludla Sihle E Mabhida Khanyisani Ziqubu Bongani B Nkambule Sithandiwe E Mazibuko-Mbeje Sidney Hanser Albert Kotze Basson Carmen Pheiffer Andre Pascal Kengne | 2023 | World Journal of Diabetes2023，14，3： | 2 |
| 2 | Determinnts of health-related quality of life in patients with chronic liver diseases显示文摘 | Hanser W Holtman G Grandt D | 2004 | Clin Gastroenterol Hepatol2004，2，2： | 1 |
| 3 | Effect of cardiac resunchronization therapy on ventricular repolarization in patients with congestive heart failure显示文摘 | Berger T Hanser F Hintringer F | 2005 | J Cardiovase Electrophysiol2005，16，6： | 1 |
| 4 | No-tillage effects on in filtration,runoff and water conservation on dryland显示文摘 | JONES O R HANSER V L | 1994 | American Society of Agriculture Engineers1994，37，2： | 1 |
| 5 | Allelopathy in the prynmesiophyte Chrysodromulina olylepis : effect of cell concentration, growth phase and pH显示文摘 | Schmidt I E Hanser P J | 2001 | Marine Ecology Progress Series2001，216，： | 1 |
| 6 | Designing, planning, and selling project A 显示文摘 | Shields JL Hanser LM | 1990 | Pers Psychol1990，43，2： | 1 |
| 7 | Fabrication and characterization of native non-polar GaN substrates 显示文摘 | HANSER D LIU L PREBLE E A | 2008 | Journal of Crystal Growth2008，310，： | 1 |
| 8 | Deaths and eardio-vaseu- lar injuries due to devieeassisted implantable eardioverter-defibril- lator and pacemaker lead extraction 显示文摘 | Robert G Hanser T Katsiyiannis | 2010 | Europaee2010，12，： | 1 |
| 9 | Regulation ofactin dynamics through phosphorylation of cofilin by LIM-kinase 显示文摘 | Arber S Barbayannis FA Hanser H | 1998 | Nature1998，393，6687： | 1 |
| 10 | Synthetic cationic amphiphilic alpha-helical peptides as antimierobial agents 显示文摘 | Wiradharma N Khoe U Hanser C | 2011 | Biomaterials2011，32，： | 1 |
| 11 | Characterization of silicon photodiode detectors with multilayer filter coatings for 17~150 (A)显示文摘 | SEELY F KORDE R HANSER F | 1999 | SPIE1999，3764，： | 1 |
| 12 | No-tillage effects on infiltration,runoffand water conservation on dryland显示文摘 | Jones O R Hanser V L | 1994 | American Society of Agriculture Engineers1994，37，2： | 1 |
| 13 | A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause显示文摘 | HANSER KR KNOWLTON NS THYER AC | 2008 | Human Reproduction2008，23，3： | 1 |
| 14 | A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors显示文摘 | Hanser HP Bardrotton Pyronolak s G | 1998 | J Cell Biol1998，141，06： | 1 |
| 15 | No-tillage effects on infiltration, runoff and water conservation on dryland显示文摘 | Jones O R Hanser V L | 1994 | American Society of Agriculture Engineers1994，37，2： | 1 |
| 16 | A giant ubiquitin-conjugating enlyme related to IAP apoptosis in- hibitors显示文摘 | Hanser HP Bardrotton M Pyronotakis G | 1998 | J Cell Biol1998，141，6： | 1 |
| 17 | Influence of surface roughness of prestressing strand on band performance 显示文摘 | Hanser N W | 1969 | Journal of Prestressed Concrete Institute1969，14，1： | 1 |
| 18 | Synthesis of certain N,N-dialkylethylenediamines显示文摘 | BLOOM M S BRESEON D S HANSER C R | 1945 | J Am Chem Soc1945，61，3： | 1 |
| 19 | Re-calibration of NBS lead standmds using a ^202Pb-^205Pb double spike 显示文摘 | Todt W Cliff R A Hanser A Hofmann A W | 1993 | Terra Abstract1993，5，1： | 1 |
| 20 | The effect of triethylene glycol dimethacrylate on the cell cycle of mammalian cells显示文摘 | Schweikl H Altmannberger I Hanser N | 2005 | Biomaterials2005，26，19： | 1 |
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