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| 1 | Clinical and cost impact of intravenous proton pump inhibitor use in non-ICU patients显示文摘AIM:To assess the appropriateness of the indication and route of administration of proton-pump-inhibitors (PPIs) and their associated cost impact. METHODS:Data collection was performed prospec-tively during a 6-mo period on 340 patients who re-ceived omeprazole intravenously during their hospital stay in non-intensive care floors. Updated guidelines were used to assess the appropriateness of the indication and route of administration. RESULTS:Complete data collection was available for 286 patients which were used to assess intravenous (IV) PPIs utilization. Around 88% of patients were receiving PPIs for claimed stress ulcer prophylaxis (SUP) indication; of which,only 17% met the guideline criteria for SUP indication,14% met the criteria for non-steroidal-anti-inflammatory drugs-induced ulcer prophylaxis,while the remaining 69% were identifi ed as having an unjustified indication for PPI use. Theinitiation of IV PPIs was appropriate in 55% of pa-tients. Half of these patients were candidates for switching to the oral dosage form during their hos-pitalization,while only 36.7% of these patients were actually switched. The inappropriate initiation of PPIs via the IV route was more likely to take place on the medical floor than the surgical floor (53% vs 36%,P = 0.003). The cost analysis associated with the appro-priateness of the indication for PPI use as well as the route of administration of PPI revealed a possible saving of up to $17 732.5 and $14 571,respectively. CONCLUSION:This study highlights the over-utili-zation of IV PPIs in non-intensive care unit patients. Restriction of IV PPI use for justified indications and route of administration is recommended. | Soumana C Nasser Jeanette G Nassif Hani I Dimassi | 2010 | World Journal of Gastroenterology2010，16，8： | 23 |
| 2 | Aspirin use for primary prophylaxis: Adverse outcomes in non-variceal upper gastrointestinal bleeding显示文摘AIM: To compare outcomes of patients with nonvariceal upper gastrointestinal bleeding(NVUGIB) taking aspirin for primary prophylaxis to those not taking it.METHODS: Patients not known to have any vascular disease(coronary artery or cerebrovascular disease) who were admitted to the American University of Beirut Medical Center between 1993 and 2010 with NVUGIB were included. The frequencies of in-hospital mortality, re-bleeding, severe bleeding, need for surgery or embolization, and of a composite outcome defined as the occurrence of any of the 4 bleeding related adverse outcomes were compared between patients receiving aspirin and those on no antithrombotics. We also compared frequency of in hospital complications and length of hospital stay between the two groups.RESULTS: Of 357 eligible patients, 94 were on aspirin and 263 patients were on no antithrombotics(controlgroup). Patients in the aspirin group were older, the mean age was 58 years in controls and 67 years in the aspirin group(P < 0.001). Patients in the aspirin group had significantly more co-morbidities, including diabetes mellitus and hypertension [25(27%) vs 31(112%) and44(47%) vs 74(28%) respectively,(P = 0.001)], as well as dyslipidemia [21(22%) vs 16(6%), P < 0.0001).Smoking was more frequent in the aspirin group [34(41%) vs 60(27%), P = 0.02)]. The frequencies of endoscopic therapy and surgery were similar in both groups. Patients who were on aspirin had lower inhospital mortality rates(2.1% vs 13.7%, P = 0.002),shorter hospital stay(4.9 d vs 7 d, P = 0.01), and fewer composite outcomes(10.6% vs 24%, P = 0.01). The frequencies of in-hospital complications and re-bleeding were similar in the two groups.CONCLUSION: Patients who present with NVUGIB while receiving aspirin for primary prophylaxis had fewer adverse outcomes. Thus aspirin may have a protective effect beyond its cardiovascular benefits. | Karina M Souk Hani M Tamim Hussein A Abu Daya Don C Rockey Kassem A Barada | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 3 |
| 3 | Single vs dual(en bloc) kidney transplants from donors ≤ 5 years of age: A single center experience显示文摘AIM: To compare outcomes between single and dual en bloc(EB) kidney transplants(KT) from small pediatric donors. METHODS: Monocentric nonprospective review of KTs from pediatric donors ≤ 5 years of age. Dual EB KT was defined as keeping both donor kidneys attached tothe inferior vena cava and aorta, which were then used as venous and arterial conduits for the subsequent transplant into a single recipient. Donor age was less useful than either donor weight or kidney size in decision-making for kidney utilization as kidneys from donors < 8 kg or kidneys < 6 cm in length were not transplanted. Post-transplant management strategies were standardized in all patients.RESULTS: From 2002-2015, 59 KTs were performed including 34 dual EB and 25 single KTs. Mean age of donors(17 mo vs 38 mo, P < 0.001), mean weight(11.0 kg vs 17.4 kg, P = 0.046) and male donors(50% vs 84%, P = 0.01) were lower in the dual EB compared to the single KT group, respectively. Mean cold ischemia time(21 h), kidney donor profile index(KDPI; 73% vs 62%) and levels of serum creatinine(SCr, 0.37 mg/d L vs 0.49 mg/d L, all P = NS) were comparable in the dual EB and single KT groups, respectively. Actuarial graft and patient survival rates at 5-years follow-up were comparable. There was one case of thrombosis resulting in graft loss in each group. Delayed graft function incidence(12% dual EB vs 20% single KT, P = NS) was slightly lower in dual EB KT recipients. Initial duration of hospital stay(mean 5.4 d vs 5.6 d) and the one-year incidences of acute rejection(6% vs 16%), operative complications(3% vs 4%), and major infection were comparable in the dual EB and single KT groups, respectively(all P = NS). Mean 12 mo SCr and abbreviated MDRD levels were 1.17 mg/d L vs 1.35 mg/d L and 72.5 m L/min per 1.73 m^2 vs 60.5 m L/min per 1.73 m^2(both P = NS) in the dual EB and single KT groups, respectively. CONCLUSION: By transplanting kidneys from young pediatric donors into adult recipients, one can effectively expand the limited donor pool and achieve excellent medium-term outcomes. | Yousef Al-Shraideh Umar Farooq Hany El-Hennawy Alan C Farney Amudha Palanisamy Jeffrey Rogers Giuseppe Orlando Muhammad Khan Amber Reeves-Daniel William Doares Scott Kaczmorski Michael D Gautreaux Samy S Iskandar Gloria Hairston Elizabeth Brim Margaret Mangus Robert J Stratta | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 4 | Non-Hodgkin lymphoma and Hodgkin disease:coregistered FDG PET and CT at staging and restaging do we need contrast-enhanced CT?显示文摘 | Schaefer NG Hany TF Taverna C | 2004 | Radiology2004，232，3： | 1 |
| 5 | Current-mode triple and quadruple langmuir probe methods with applications to flowing pulsed plasmas 显示文摘 | Gatsonis N A Byrne L T Zwahlen J C Pencil E J and Kamhawi Hani | 2004 | IEEE Transactions on Plasma Science2004，32，5： | 1 |
| 6 | A community-based, culturally sensitive education and group-support intervention for mexican Americans with NIDDM:A pilot study of efficacy显示文摘 | Brown S A Hanis C L | 1995 | TDF1995，21，3： | 1 |
| 7 | CT 68Ge Attenuation Correction in a Combined PET/CT System:Evaluation of the Effect of lowering the CT Tube Current显示文摘 | Kamel E Hany TF Burger C | 2002 | Eur J Nucl Med Mol Imaging2002，29，3： | 1 |
| 8 | Non-Hodgkin lymphoma and Hodgkin disease:coregistered FDG PET and CT at staging and restaging-do we need contrast-enhanced CT显示文摘 | Schaefer NG Hany TF Taverna C | | 0，，： | 1 |
| 9 | CT vs 68Ge attenuation correction in a combined PET/CT system: evaluation of the effect of lowering the CT tube current显示文摘 | Kamel E Hany TF Burger C | 2002 | Eur J Nucl Med2002，29，3： | 1 |
| 10 | Exposing digital forgeries in color filter array interpolated images显示文摘 | Alin C Popescu Hany Farid | 2005 | IEEE Transactions on Signal Processing2005，53，10： | 1 |
| 11 | PET diagnostic accuracy improvement with in line PET-CT system: initial results显示文摘 | HANY T F STEINERT H C GOERRES G W | 2002 | Radiology2002，225，2： | 1 |
| 12 | The trans-10,cis-12 iso- mer of conjugated linoleie acid downregulates stearoy]-CoAdesaturase 1 gene expression in 3T3-L1 adipoeytes 显示文摘 | CHOI Y KIMY C HANY B | 2000 | J Nu- tr2000，130，： | 1 |
| 13 | Exposing digital forgeries by detecting traces of resampling 显示文摘 | Alin C Popescu Hany Farid | 2005 | IEEE Transactions on Signal Processing2005，53，2： | 1 |
| 14 | Ocular and cardiovascular pharmacology of tetramethylpyrazine isolated from Ligusticum wallichii Franch 显示文摘 | Chou C Y Yan Hanying Lei Xanlan | 1991 | Acta Pharmacol Sin1991，12，2： | 1 |
| 15 | Toward Non-Toxic Anti- fouling: Synthesis of Hydroxy -, Cinnamic Acid -, Sulfate -, and Zosteric Acid- Labeled Poly 显示文摘 | Hany R Bohlen C Geiger T | 2004 | Biomacromolecules2004，5，4： | 1 |
| 16 | The Maccabi Glaucoma Study:prevalence and incidence of glaucoma in a large Israeli health main-tenance organization 显示文摘 | Hani LV Inbal G Gabriel C | 2014 | American Journal of Ophthalmology2014，158，2： | 1 |
| 17 | Toward non-toxic antifouling: Synthesis of hydroxyl-, cinnamic acid-, sulfate-, and zosteric acid-labeled poly 显示文摘 | Hany R Bohlen C Geiger T | 2004 | Biomacromolecules2004，5，4： | 1 |
| 18 | Non-Hodgkin lymphoma and Hodgkin disease:coregistered FDG PET and CT at staging and restaging-do we need contrast-enhanced CT?显示文摘 | Schaefer NG Hany TF Taverna C | 2004 | Radiology2004，232，3： | 1 |
| 19 | Aspirin and clopidogrel in acute coronary sysdromes:Therapeutic insights from the CURE study显示文摘 | Hani J Deepak LB Roberto C | 2003 | Arch Intern Med2003，163，： | 1 |
| 20 | Validation of the occurrence of short-finned eel AnguiUa bicolor pacifica in natural waters of Taiwan 显示文摘 | HANY S CHANG C W HE J T | 2001 | Aeta Zoologica Taiwaniea2001，12，1： | 1 |
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