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| 1 | Glucosamine and chondroitin for the treatment of osteoarthritis显示文摘The prevalence of primary or idiopathic osteoarthritis(OA) of knee and hip joints has substantially increased in general population during the last decades. Analgesics and non-steroidal anti-inflammatory drugs are currently extensively used as non-surgical treatmentoptions. However, they act as symptomatic treatments, not offering a cure of OA and they are accused for an increased risk of adverse events. Glucosamine(GL) and chondroitin(CH) are nutritional supplements that have recently gained widespread use as treatment options for OA. They potentially or theoretically act as chondroprotectors or/and as 'disease-modifying OA drugs' offering not only symptomatic relief but also alteration of the natural history of OA. However, although many studies have showed a significant treatment effect, accompanied with remarkable safety, there is still controversy regarding their relative effectiveness compared with placebo or other treatments. The scope of this review is to present and critically evaluate the current evidence-based information regarding the administration of GL and CH for the treatment of knee or hip OA. Our focus is to investigate the clinical efficacy and safety after the use of these supplements. An effect of GL and CH on both clinical and radiological findings has been shown. However, only a few high-quality level I trials exist in the literature, especially on the assessment of radiological progression of OA. The effect sizes are generally small and probably not clinically relevant. Even the validity of these results is limited by the high risk of bias introduced in the studies. Both GL and CH seem to be safe with no serious adverse events reported. There is currently no convincing information for the efficacy of GL and CH on OA. | Haris S Vasiliadis Konstantinos Tsikopoulos | 2017 | World Journal of Orthopedics2017，8，1： | 10 |
| 2 | Expression profile of cholecystokinin type-A receptor in gallbladder cancer and gallstone disease显示文摘BACKGROUND:Regulatory peptide receptors have attracted the interest of oncologists as a new promising approach for cancer pathology,imaging and therapy.Although cholecystokinin (CCK) is a potent modulator of gallbladder contractility and plays a potential role in pancreatic carcinogenesis through CCK type-A receptor (CCKAR),its role in gallbladder cancer (GBC) is still unknown and immunohistochemical detection of CCKAR in the gallbladder has not yet been reported.This novel case-control study aimed to investigate the expression profile of CCKAR in GBC and gallstone disease (GSD).METHODS:This study included 162 samples of gallbladder:94 from GBC and 68 from GSD.Expression of CCKAR was analyzed by immunohistochemistry and immunoblotting.The results were statistically correlated with disease history including age,sex,presence of gallstone,stage and differentiation.RESULTS:CCKAR was positive in 30/68 (44.1%) of GSD and 72/94 (76.6%) of GBC samples.Fifty-one of the 72 (70.8%) CCKAR-positive GBC samples showed over-expression.Interestingly,consistent results also appeared in the immunoblotting study.CONCLUSIONS:CCKAR expression was significantly increased in GBC compared to GSD.Moreover,CCKAR expression was associated with the degree of tumor differentiation,i.e.,less expression in poorly-differentiated tumors.Thus,it has future prognostic and therapeutic implications in the management of GBC. | Rajani Rai Mallika Tewari Mohan Kumar Tej Bali Singh Hari S Shukla | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 7 |
| 3 | WJSC 6^(th) Anniversary Special Issues(1):Hematopoietic stem cell transplantation Allogeneic hematopoietic cell transplant for acute myeloid leukemia:Current state in 2013 and future directions显示文摘Acute myeloid leukemia(AML)represents a heterogeneous group of high-grade myeloid neoplasms of the elderly with variable outcomes.Though remissioninduction is an important first step in the management of AML,additional treatment strategies are essential to ensure long-term disease-free survival.Recent pivotal advances in understanding the genetics and molecular biology of AML have allowed for a risk-adapted approach in its management based on relapse-risk.Allogeneic hematopoietic cell transplantation(allo-HCT)represents an effective therapeutic strategy in AML providing the possibility of cure with potent graft-versus-leukemia reactions,with a demonstrable survival advantage in younger patients with intermediate-or poor-risk cytogenetics.Herein we review the published data regarding the role of allo-HCT in adults with AML.We searched MEDLINE/PubMed and EMBASE/Ovid.In addition,we searched reference lists of relevant articles,conference proceedings and ongoing trial databases.We discuss the role of allo-HCT in AML patients stratified by cytogenetic-and molecular-risk in first complete remission,as well as allo-HCT as an option in relapsed/refractory AML.Besides the conventional sibling and unrelated donor allografts,we review the available data and recent advances for alternative donor sources such as haploidentical grafts and umbilical cord blood.We also discuss conditioning regimens,including reduced intensity conditioning which has broadened the applicability of allo-HCT.Finally we explore recent advances and future possibilities and directions of allo-HCT in AML.Practical therapeutic recommendations have been made where possible based on available data and expert opinion. | Abraham S Kanate Marcelo C Pasquini Parameswaran N Hari Mehdi Hamadani | 2014 | World Journal of Stem Cells2014，6，2： | 6 |
| 4 | Salmonella typhi and gallbladder cancer:report from an endemic region显示文摘BACKGROUND:Evidence exists of a link between chronic infection by Salmonella typhi(S.typhi) and the development of gallbladder cancer(GBC),but several studies from endemic regions contradict its role in the etiopathogenesis of GBC.This study used various tools to assess the prevalence of S.typhi in patients with GBC and gallstone disease(GSD) in this region with a high incidence of GBC.METHODS:S.typhi was detected in tissue and bile by PCR and culture and in serum by the Widal test and indirect hemagglutination assay(IHA).PCR with two pairs of S.typhi specific primers(flagellin gene H1d and SOP E gene) could detect 0.6 ng of S.typhi DNA.Fifty-four patients with GBC(cases) were matched with 54 patients with GSD(controls).RESULTS:Of the 54 cases,24(44.44%) were positive on the Widal test and 12(22.22%) on IHA,compared to 13(24.07%) and 5(9.26%) respectively in the controls.Eighteen(33.33%) cases showed a positive result on PCR(tissue) and 2 on PCR(bile) vs.none in the controls.Bile culture revealed no Salmonella colonies in either cases or controls.Only 3 cases were positive for Salmonella on tissue culture compared to none in the controls.The sensitivity of PCR(tissue) relative to the Widal test,IHA,culture(bile and tissue) and PCR(bile) was 100% vs.66.67%,11.11%,and 11.11%,and the specificity was 83.33% vs.100%,100%,and 100%,respectively.CONCLUSIONS:S.typhi is significantly associated with GBC compared to GSD(33% vs.0%).PCR appears to be the most specific diagnostic tool,the gold standard for S.typhi in tissue samples. | Mallika Tewari Raghvendra R Mishra Hari S Shukla | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，5： | 5 |
| 5 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 6 | Hybrid image segmentation using watersheds and fast region merging显示文摘 | Haris K Efstratiadis S N | 1998 | IEEE Transactions on Image Processing1998，7，12： | 1 |
| 7 | Hybrid Image Segmentation Using Watersheds and Fast Region Merging显示文摘 | Haris K Efstratiadis S N Maglaveras N | 1998 | Image Processing1998，7，12： | 1 |
| 8 | Low-grade central osteosarcoma of distal femur, resembling fibrous dysplasia显示文摘We report a case of a 32 year-old male, admitted for a lytic lesion of the distal femur. One month after the first X-ray, clinical and imaging deterioration was evident. Open biopsy revealed fibrous dysplasia. Three months later, the lytic lesion had spread to the whole distal third of the femur reaching the articular cartilage. The malignant clinical and imaging features necessitated excision of the lesion and reconstruction with a custom-made total knee arthroplasty. Intraoperatively, no obvious soft tissue infiltration was evident. Nevertheless, an excision of the distal 15.5 cm of the femur including 3.0 cm of the surrounding muscles was finally performed. The histological examination of the excised specimen revealed central low-grade osteosarcoma. Based on the morphological features of the excised tumor, allied to the clinical findings, the diagnosis of low-grade central osteosarcoma was finally made although characters of a fibrous dysplasia were apparent. Central low-grade osteosarcoma is a rare, well-differentiated sub-type of osteosarcoma, with clinical, imaging, and histological features similar to benign tumours. Thus, initial misdiagnosis is usual with the condition commonly mistaken for fibrous dysplasia. Central low-grade osteosarcoma is usually treated with surgery alone, with rare cases of distal metastases. However, regional recurrence is quite frequent after close margin excision. | Haris S Vasiliadis Christina Arnaoutoglou Sotiris Plakoutsis Michalis Doukas Anna Batistatou Theodoros A Xenakis | 2013 | World Journal of Orthopedics2013，4，4： | 1 |
| 9 | Thermal stability of biodiesel in supercritical methanol显示文摘 | IMAHARA H MINAMI E HARI S | 2008 | Fuel2008，87，： | 1 |
| 10 | Performance analysis of Root_MUSIC显示文摘 | RAO B D HARI K V S | 1989 | IEEE Trans on ASSP1989，37，12： | 1 |
| 11 | Hybrid image segmentation using watersheds and fast region merging 显示文摘 | HARIS K EFSTRATIADIS S | 1998 | IEEE Transaction on Image Processing1998，7，12： | 1 |
| 12 | An overall aspect of electroless NiP depositions显示文摘 | Hari K Krishnan S J | 2006 | Metallurgical and Materials Transactions2006，37，6： | 1 |
| 13 | Hybrid image segmentation using watersheds and fast region merging显示文摘 | Haris K Efstratiadis S N Maglaveras N | 1998 | IEEE Transactions on image processing1998，7，12： | 1 |
| 14 | Enzymatic synthsis ofisoamyl butyrate using immobilized Rhizomucor miehei lipase in non-aqueous media显示文摘 | S Hari Krishna SG Pmpulla NG Karanth | 2000 | Joural of Industry Microbiology &Biotechnology2000，，25： | 1 |
| 15 | A survey of arsenic in foodstuffs on sale in the United Kingdom and imported from Bangladesh 显示文摘 | ALRMALLI S W HARIS P L HARRINGTON C F | 2005 | Science of the Total Environment2005，337，13： | 1 |
| 16 | Deviant auditory stimuli activate human left and right auditory cortex differently显示文摘 | Levanen S Ahonen A Hari R | 1996 | Cerebral Cortex1996，6，： | 1 |
| 17 | Hybrid image segmentation using watersheds and fast regionmerging显示文摘 | HARIS K EFSTRATIADIS S N MAGLAVERAS N | 1998 | IEEE Trans on Image Processing(S1057-7149)1998，7，12： | 1 |
| 18 | Automated coronary artery extraction using watersheds 显示文摘 | Haris K Efstratiadis S N Maglaveras N | 1997 | IEEE Computers in Cardiology1997，24，： | 1 |
| 19 | Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as a-glucosidase inhibitors显示文摘 | HARI B T RAMA S R V TIWARI A K | 2008 | Bioorg Med Chem Lett2008，18，5： | 1 |
| 20 | Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis 显示文摘 | Davila S Hibberd ML Hari Dass R Wong HE Sahiratmadja E Bonnard C | 2008 | PLoS Genet2008，4，10： | 1 |
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