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| 1 | Protective action of glutamine in rats with severe acute liver failure显示文摘BACKGROUND Severe acute liver failure(SALF) is a rare, but high-mortality, rapidly evolving syndrome that leads to hepatocyte degeneration with impaired liver function.Thioacetamide(TAA) is a known xenobiotic, which promotes the increase of the formation of reactive oxygen species. Erythroid 2-related factor 2(Nrf2) activates the antioxidant protection of cells. Studies have evidenced the involvement of inflammatory mediators in conditions of oxidative stress.AIM To evaluate the antioxidant effects of glutamine on Nrf2 activation and NFκBmediated inflammation in rats with TAA-induced IHAG.METHODS Male Wistar rats(n = 28) were divided into four groups: control,control+glutamine, TAA, and TAA + glutamine. Two TAA doses(400 mg/kg)were administered intraperitoneally, 8 h apart. Glutamine(25 mg/kg) was administered at 30 min, 24 h, and 36 h. At 48 h, blood was collected for liver integrity analysis [aspartate aminotransferase(AST), alanine aminotransferase(ALT), and alkaline phosphatase(ALP)]. The liver was harvested for histology and assessment of oxidative stress [thiobarbituric acid-reactive substances(TBARS), catalase(CAT), glutathione peroxidase(GPx), glutathione S-transferase(GST), glutathione(GSH), Nrf2, Kelch-like ECH-associated protein 1(Keap1),NADPH quinone oxidoreductase1(NQO1), superoxide dismutase(SOD)] and inflammatory process.RESULTS TAA caused disruption of the hepatic parenchyma, with inflammatoryinfiltration, massive necrosis, and ballooning degeneration. Glutamine mitigated this tissue damage, with visible regeneration of hepatic parenchyma; decreased TBARS(P < 0.001), GSH(P < 0.01), IL-1β, IL6, and TNFα levels(P <0.01) in hepatic tissue; and decreased blood levels of AST, ALT, and ALP(P <0.05). In addition, CAT, GPx, and GST activities were restored in the glutamine group(P<0.01, P <0.01, and P <0.001, respectively vs TAA alone). Glutamine increased expression of Nrf2(P < 0.05), NQO1, and SOD(P < 0.01), as well as levels of IL-10(P <0.001), while decreasing expression of Keap1, TLR4, NFκB(P < 0.001), COX-2 and iNOS,(P < 0.01), and reducing NO_2 and NO_3 levels(P < 0.05).CONCLUSION In the TAA experimental model of IHAG, glutamine activated the Nrf2 pathway,thus promoting antioxidant protection, and blunted the NFκB-mediated pathway, reducing inflammation. | Elizangela G Schemitt Renata M Hartmann Josieli R Colares Francielli Licks Jéferson O Salvi Cláudio A Marroni Norma P Marroni | 2019 | World Journal of Hepatology2019，11，3： | 5 |
| 2 | Compared efficacy of preservation solutions on the outcome of liver transplantation:Meta-analysis显示文摘AIM To compare the effects of the four most commonly used preservation solutions on the outcome of liver transplantations.METHODS A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the Cochrane Library databases up to January 31^(st), 2017. The inclusion criteria were comparative, randomized controlled trials(RCTs) for deceased donor liver(DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin(UW) solution or histidinetryptophan-ketoglutarate(HTK), Celsior(CS) and Institut Georges Lopez(IGL-1) solutions. Fifteen RCTs(1830 livers) were included; the primary outcomes were primary non-function(PNF) and one-year posttransplant graft survival(OGS-1). RESULTS All trials were homogenous with respect to donor and recipient characteristics. There was no statistical difference in the incidence of PNF with the use of UW, HTK, CS and IGL-1(RR = 0.02, 95%CI: 0.01-0.03, P = 0.356). Comparing OGS-1 also failed to reveal any difference between UW, HTK, CS and IGL-1(RR = 0.80, 95%CI: 0.80-0.80, P = 0.369). Two trials demonstrated higher PNF levels for UW in comparison with the HTK group, and individual studies described higher rates of biliary complications where HTK and CS were used compared to the UW and IGL-1 solutions. However, the meta-analysis of the data did not prove a statistically significant difference: the UW, CS, HTK and IGL-1 solutions were associated with nearly equivalent outcomes.CONCLUSION Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDLs, but further well-designed clinical trials are warranted. | Agnes Lilla Szilágyi Péter Mátrai Péter Hegyi Eszter Tuboly Daniella Pécz András Garami Margit Solymár Erika Pétervári Márta Balaskó Gábor Veres László Czopf Bastian Wobbe Dorottya Szabó Juliane Wagner Petra Hartmann | 2018 | World Journal of Gastroenterology2018，24，16： | 5 |
| 3 | High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein显示文摘 | Hartmann G Tschop M Fischer R | 2002 | Cytokine2002，12，3： | 1 |
| 4 | Outcomes of routine episiotomy : a systematic review 显示文摘 | Hartmann K Viswanathan M Palmieri R | 2005 | JAMA2005，293，： | 1 |
| 5 | High altitude increases circulating interleukin-6,interleukin-1 receptor antagonist and C-reactive protein显示文摘 | Hartmann G Tschop M Fischer R | 2000 | Cytokine2000，12，3： | 1 |
| 6 | Outcomes of routine episiotomy:a systematic review显示文摘 | Hartmann K Viswanathan M Palmieri R | 2005 | JAMA2005，293，： | 1 |
| 7 | High altitude increases circu- lating interleukin-6, interleukin-1 receptor antagonist and C-reac- tive protein显示文摘 | Hartmann G Tschop M Fischer R | 2000 | Cytokine2000，12，3： | 1 |
| 8 | Design and synthesis of 1, 3, 5-trisubstituted 1, 2, 4- triazoles as CYP enzyme inhibitors 显示文摘 | AL SOUD Y A HEYDEL M HARTMANN R W | 2011 | Tetrahedron Lett2011，52，48： | 1 |
| 9 | Perovskite manganites: potential materials for magnetic cooling at or near room temperature 显示文摘 | Xu Y Meier M Das P Koblischka M R Hartmann U | 2002 | Crystal Engineering2002，5，： | 1 |
| 10 | Diversity of carbofuran-degrading soil bacteria and detection of plasmidencoded sequences homologous to the med gene显示文摘 | Parrkh N R Hartmann A Charnay M P | 1995 | FEMS Microbiol Ecol1995，17，： | 1 |
| 11 | Outcomes oroutine episiotomy:a systematic review显示文摘 | Hartmann K Kiswanathan M Palmieri R | | 0，，： | 1 |
| 12 | Fatal subarachnoid hemorrhage after carotid stenting 显示文摘 | Hartmann M Weber R Zoubaa S | 2004 | J Neuroradiol2004，31，1： | 1 |
| 13 | Fatal Subarachnoid Hemorrhage after Carotid Stenting显示文摘 | HARTMANN M WEBER R ZOUBAA S | 2004 | J Neuroradiol(S0150-9861)2004，3，1： | 1 |
| 14 | High altitude increases circulating interleukin- 6 ,interleukin - 1 receptor antagonist and C - reactive protein显示文摘 | Hartmann G Tschop M Fischer R | 2000 | Cytokine2000，12，3： | 1 |
| 15 | Outcomes ofRoutine Episiotomy:a Systematic Review显示文摘 | Hartmann K Viswanathan M Palmieri R | 2005 | JAMA2005，293，17： | 1 |
| 16 | Planning your firm Is R&D investment 显示文摘 | Hartmann G C Myers M B Rosenbloom R S | 2006 | Research Technology Management2006，49，2： | 1 |
| 17 | A param eterization for the threshold shear velocity to initiate deflation of dry and wet sediment 显示文摘 | Comelis W M Gabriels D Hartmann R | 2004 | Geomorphology2004，9，： | 1 |
| 18 | Outcomes of rou- tine episiotomy: a systematic review显示文摘 | Hartmann K Kiswanathan M Palmieri R | 2005 | JAMA2005，293，17： | 1 |
| 19 | Diversity of carbofuran-degrading soil bacteria and detection of plasmid-encoded sequences homologous to the med gene显示文摘 | Parrkh N R Hartmann A Charnay M P | 1995 | FEMS Microbiol Ecol1995，17，： | 1 |
| 20 | High altitude increases circulating interleukin-6,interleukin-1receptor antagonist and C-reactive protein显示文摘 | Hartmann G Tschop M Fischer R | 2000 | Cytokine2000，12，： | 1 |
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