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| 1 | Should antibiotics be administered before arthroscopic knee surgery? A systematic review of the literature显示文摘AIM To explore the current evidence surrounding the administration of prophylactic antibiotics for arthroscopic knee surgery. METHODS Databases were searched from inception through May of 2018 for studies examining prophylactic antibiotic use and efficacy in knee arthroscopy. Studies with patient data were further assessed for types of arthroscopic procedures performed,number of patients in the study,use of antibiotics,and outcomes with the intention of performing a pooled analysis. Data pertaining to 'deep tissue infection' or 'septic arthritis' were included in our analysis. Reported data on superficial infection were not included in our data analysis. For the pooled analysis,a relative risk ratio was calculated and χ~2 tests were used to assess for statistical significance between rates of infection amongst the various patient groups. Post hoc power analyses were performed to compute the statistical power obtained from our sample sizes. Number needed to treat analyses were performed for statistically significant differences by dividing 1 by the difference between the infection rates of the antibiotic and no antibiotic groups. An alpha value of 0.05 was used for our analysis. Study heterogeneity was assessed by Cochrane's Q test as well as calculation of the I^2 value.RESULTS A total of 49682 patients who underwent knee ar-throscopy for a diverse set of procedures across 19 studies met inclusion critera for pooled analysis. For those not undergoing graft procedures,there were 27 cases of post-operative septic arthritis in 34487 patients(0.08%) who received prophylactic antibiotics and 16 cases in 10911(0.15%) who received none [risk ratio(RR) = 0.53,95% confidence interval(CI): 0.29-0.99,P = 0.05]. A sub-group analysis in which bony procedures were excluded was performed which found no significant difference in infection rates between patients that received prophylactic antibiotics and patients that did not(P > 0.05). All anterior cruciate ligament reconstruction studies used prophylactic antibiotics,but two studies investigating the effect of soaking the graft in vancomycin in addition to standard intravenous(IV) prophylaxis were combined for analysis. There were 19 cases in 1095 patients(1.74%) who received IV antibioitics alone and no infections in 2034 patients who received IV antibiotics and had a vancomycin soaked graft(RR = 0.01,95%CI: 0.001-0.229,P < 0.01).CONCLUSION Prophylactic antibiotics are effective in preventing septic arthritis following simple knee arthroscopy. In procedures involving graft implantation,graft soaking reduces the rate of infection. | John Carney Nathanael Heckmann Erik N Mayer Ram K Alluri Carleton Thomas Vangsness George F Hatch Ⅲ Alexander E Weber | 2018 | World Journal of Orthopedics2018，9，11： | 2 |
| 2 | feces and feathers can indicateintra-individual changes in the diet of migratory songbirds 显示文摘 | Podlesak D W McWilliams S R Hatch K A Stable isotopes in breath blood | 2005 | OecoLogia2005，142，4： | 1 |
| 3 | Tumors of the Small Intestine显示文摘 | Blanehard D K Badde J M Hatch G F | 2000 | Word J Surg2000，24，： | 1 |
| 4 | Analysis of atmospheric aerosols显示文摘 | Prather K A Hatch C D Grassian V H | | 0，，： | 1 |
| 5 | Garments As Solar Ultraviolet Radiation Screening Materials 显示文摘 | HATCH K L OSTERWALDER U | 2006 | Dermato- logic Clinics2006，24，1： | 1 |
| 6 | Multiple genetic changes can occur in the oral polio vaccines upon replication in humans显示文摘 | Nottay B K Hatch M H | 1998 | J Gen Virol1998，156，： | 1 |
| 7 | Predicting performance of optical systems undergoing thermal/mechanical loadings using integrated thermal/structural/optical numerical methods显示文摘 | MILLER J HATCH M GREEN K | 1981 | Optical Engineering1981，20，： | 1 |
| 8 | Tumors of the small intestine显示文摘 | Blanchard D K Budde J M Hatch G F | 2000 | World J Surg2000，24，4： | 1 |
| 9 | Effect of exercise garment fabric and environment on cutaneous conditions of human subjects显示文摘 | MARKEE N L HATCH K L FRENCH S N | 1991 | Clothing and Textile Research Journal1991，9，4： | 1 |
| 10 | Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations显示文摘 | Driscoll K E Costa D L Hatch G | 2000 | Toxicol Sci2000，55，1： | 1 |
| 11 | Diethylstilbestrol revisited: a review of the long term health effects显示文摘 | GINSTI R M IVAMOTO K HATCH E E | 1995 | Ann Interm Med1995，122，： | 1 |
| 12 | Laparoscopic as- sisted surgical staging (LASS)of endometrial cancer显示文摘 | Childers J M Brzechffa P R Hatch K D | 1993 | Gynecol Oncol1993，51，： | 1 |
| 13 | Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection - California, April-May, 2009显示文摘 | Louie J Winter K Harriman K Vugia D Glaser C Matyas B Schnurr D Guevara H Pan C Y Saguar E Berumen R Hunley E Messenger S Preas C Hatch D Chavez G Kriner P Lopez K Sunega D Rexin D Roach S Kempf J Gonzalez R Morgan L Barnes N Berm | 2009 | MMWR Morbidity and Mortality Weekly Report2009，，19： | 1 |
| 14 | Origin of Minerals in Joint and Cleat Systems of the Pottsville Formation, Black Warrior Basin, Alabama: Implications for Coalbed Methane Generation and Production 显示文摘 | Pitman J K Pashin J C Hatch J R | 2003 | AAPG Bulletin2003，87，5： | 1 |
| 15 | Laparoscopic assisted surgical staging(LASS) of endometrial cancer显示文摘 | Childers J M Brezchffa P R Hatch K D | 1993 | Gynecol Oncol1993，51，1： | 1 |
| 16 | Impact of nostalgia and past experience on recreational demand for wilderness显示文摘 | ACHARYA N PAUDEL K P HATCH L U | | 0，，05： | 1 |
| 17 | Preoperative fast- ing for paediatric anaesthesia 显示文摘 | Phillips S Daborn A K Hatch D J | 1994 | British Journal of Anaesthesia1994，73，4： | 1 |
| 18 | Swine Influenza A (H1N1) Infection in Two Children - Southern California, March-April 2009显示文摘 | Ginsberg M Hopkins J Maroufi A Dunne G Sunega D R Giessick J McVay P Lopez K Kriner P Munday S Harriman K Sun B Chavez G Hatch D Schechter R Vugia D Louie J Chung W | 2009 | MMWR Morbidity and Mortality Weekly Report2009，，15： | 1 |
| 19 | Folate deficiency and cervical dysplasia显示文摘 | Butterworth C Jr Hatch K Macalsuo M | 2004 | J Am Med Assoc2004，2，： | 1 |
| 20 | Optimization of scheduling of cleaning in heat exchanger networks subject to fouling: sugar industry case study 显示文摘 | Smaili F Angadi D K Hatch C M | 1999 | Food and Bioproducts Processing1999，77，2： | 1 |
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