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| 1 | Radiation exposure and reduction in the operating room: Perspectives and future directions in spine surgery显示文摘Intraoperative imaging is vital for accurate placement of instrumentation in spine surgery. However, the use of biplanar fluoroscopy and other intraoperative imaging modalities is associated with the risk of significant radiation exposure in the patient, surgeon, and surgical staff. Radiation exposure in the form of ionizing radiation can lead to cellular damage via the induction of DNA lesions and the production of reactive oxygen species. These effects often result in cell death or genomic instability, leading to various radiation-associated pathologies including an increased risk of malignancy. In attempts to reduce radiation-associated health risks, radiation safety has become an important topic in the medical field. All practitioners, regardless of practice setting, can practice radiation safety techniques including shielding and distance to reduce radiation exposure. Additionally, optimization of fluoroscopic settings and techniques can be used as an effective method of radiation dose reduction. New imaging modalities and spinal navigation systems have also been developed in an effort to replace conventional fluoroscopy and reduce radiation doses. These modalities include Isocentric Three-Dimensional C-Arms, O-Arms, and intraoperative magnetic resonance imaging. While this influx of new technology has advanced radiation safety within the field of spine surgery, more work is still required to overcome specific limitations involving increased costs and inadequate training. | Ankur S Narain Fady Y Hijji Kelly H Yom Krishna T Kudaravalli Brittany E Haws Kern Singh | 2017 | World Journal of Orthopedics2017，8，7： | 9 |
| 2 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 3 | An analysis of multiple staging management strategies for carcinoma of the esophagus: computed tomography, endoscopic ultrasound, positron emission tomography, and thoracoscopy/laparoscopy显示文摘 | Michael B Wallace Paul J Nietert Craig Earle Mark J Krasna Robert H Hawes Brenda J Hoffman Carolyn E Reed | 2002 | The Annals of Thoracic Surgery2002，，4： | 2 |
| 4 | Predictors of survival for esophageal cancer patients with and without celiac axis lymphadenopathy: impact of staging endosonography显示文摘 | Mohamad A Eloubeidi Michael B Wallace Brenda J Hoffman Margaret B Leveen Annette Van Velse Robert H Hawes Carolyn E Reed | 2001 | The Annals of Thoracic Surgery2001，，1： | 1 |
| 5 | Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus(UKPDS 23)显示文摘 | Turner RC Millns H Neil HAW | 1998 | BMJ1998，316，7134： | 1 |
| 6 | Fecalincontinence :prevalence,severity,and quality of life data from an outpatientgastroenterology practice 显示文摘 | ALSHEIK E H COYNE T HAWES SK | 2012 | Gastroenterol Res Pract2012，，94： | 1 |
| 7 | A double-blind randomized trial comparing the cavaterm and the novasure endometrial ablation systems for the treatment of dysfunctional uterine bleeding显示文摘 | Abbott J Hawe J David H | 2003 | Fertil Steril2003，80，1： | 1 |
| 8 | The evolution of endoscopic ultrasound: improved imaging, higher accuracy for fine needle aspiration and the reality of endoscopic ultrasound-guided interventions显示文摘 | Robert H Hawes | 2010 | Current Opinion in Gastroenterology2010，，5： | 1 |
| 9 | Standard endoscopy with random biopsies versus narrow hand imaging targeted biopsies in Barrett's esophagus: a prospective, international, randomised controlled trial 显示文摘 | Sharma P Hawes R H Bansal A | 2013 | Gut2013，62，1： | 1 |
| 10 | A model for interpretation of hyper spectral remote-sensing reflectance 显示文摘 | Lee Z P Carder K L Hawes S H | 1994 | Appl Opt1994，33，： | 1 |
| 11 | Reactome pathway analysis to enrich biological discovery in proteomics data sets 显示文摘 | Haw R Hermjakob H D'Eustachio P | 2011 | Proteomics2011，11，18： | 1 |
| 12 | Risk factors for coronary artery diseasein non - insulin dependent diabetesmellitua: UKPDS 23 显示文摘 | Tumer RC Millna H Neil HAW | 1998 | BMJ1998，316，： | 1 |
| 13 | A multispecialty approach to the diagnosis and management of pancreatic cancer显示文摘 | Robert H Hawes Qinghua Xiong Irving Waxman Kenneth J Chang Douglas B Evans James L Abbruzzese | 2000 | The American Journal of Gastroenterology2000，，1： | 1 |
| 14 | A comparison of the accuracy of eebe features during endoscopic ultrasound (EUS) and EUS-gnided fine-needle aspiration for diagnosis of malignant lymph node invasion显示文摘 | BHUTANI M S HAWES R H HOFFMAN B J | 1997 | Gastroint Enclose1997，45，6： | 1 |
| 15 | Risk factors for coronary artery disease in non-insulin-depedent diabetes mellitus:United Kindom prospective diabetes study显示文摘 | Turner RC Millns H Neil HAW | 1998 | BMJ1998，26，4： | 1 |
| 16 | For the United Kingdom Prospective Diabetes Study Group, Risk Factors for Coronary Artery Disease in Non-insulin Dependent Diabetes Mellitus ( UKPDS23 ) 显示文摘 | Millns H Neil HAW | 1998 | Br Med J1998，316，： | 1 |
| 17 | Ultimate ownership, income management, and legal and extra-legal institutions 显示文摘 | Haw I M Bingbing H Lee S Hwang W W | 2004 | Journal of Accounting Research2004，，2： | 1 |
| 18 | Supramolecular origins of product selectivity for methanol-to-olefin catalysis on HSAPO34显示文摘 | Sorg W G Fu H Haw JF | 2001 | J Am Chem SOc2001，123，20： | 1 |
| 19 | Generally recognized as safe (GRAS) evalution of 4-hexylresorcinol for use as a processing aid for prevention of melonosis in shrimp 显示文摘 | Frankos V H Schmitt D F Haws L C | 1991 | Reg Toxic Pharmocol1991，，14： | 1 |
| 20 | An oft-studied reaction that may never have been: Direct catalytic conversion of methanol or dimethyl ether to hydrocarbons on the solid acids HZSM-5 or HSAPO-34显示文摘 | SONG W G MARCUS D M FU H EHRESMANN J O HAW J F | 2002 | J Am Chem Soc2002，124，15： | 1 |
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