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		题名	作者	年代	出处	被引量
	1	LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer显示文摘Objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma(NPC).Methods DCs were derived from peripheral blood monocytes of patients with NPC.We prepared LMP2-DCs infected by recombinant adenovirus vector expressing LMP2(rAd-LMP2).NPC patients were immunized with 2×105 LMP2-DCs by intradermal injection at week 0 and after the second and fourth weeks.Specific responses to LMP2 were detected by enzyme-linked immunospot(ELISPOT)assay at week 0 and at the fifth and eighth weeks.Local clinicians performed the follow-up and tracking of patients.Results We demonstrated that DCs derived from monocytes displayed typical DC morphologies;the expression of LMP2 in the LMP2-DCs vaccine was confirmed by immunocytochemical assay.Twenty-nine patients with NPC were enrolled in this clinical trial.The LMP2-DCs vaccine was well tolerated in all of the patients.Boosted responses to LMP2 peptide sub-pools were observed in 18 of the 29 patients with NPC.The follow-up data of 29 immunized patients from April,2010 to April 2015 indicated a five-year survival rate of 94.4%in responders and 45.5%in non-responders.Conclusion In this pilot study,we demonstrated that the LMP2-DCs vaccine is safe and effective in patients with NPC.Specific CTLs responses to LMP2 play a certain role in controlling and preventing the recurrence and metastasis of NPC,which warrants further clinical testing.	ZENG Yi SI Yong Feng LAN Gui Ping WANG Zhan ZHOU Ling TANG Min Zhong SJ O`Brien LAN Jiao ZHOU Xiang Yang WANG Yong Li TANG Juan ZHOU Zhi Xiang DU Hai Jun LIN Hui	2020	Biomedical and Environmental Sciences2020，33，11：	2
	2	Comparison of adult patients hospitalized with pandemic (H1N1) 2009 influenza and seasonal influenza during the 'PROTECT' phase of the pandemic response显示文摘	Chang YS Van Hai SJ Spencer PM	2010	Med J Aust2010，192，2：	1
	3	Psychosocial variables and hospitalization in persons with chronic heart failure显示文摘	Bennett SJ Pressler ML Hays L	1997	Prog Cardiovasc Nurs1997，12，1：	1
	4	Psychosocial variables and hospitalization in persons with chronic heart failure显示文摘	Bennett SJ Pressler ML Hays L	1997	Prog Cardiovasc Nurs1997，12，4：	1
	5	Psychosocial variables and hospitalizations in persons with chronic heart failure 显示文摘	Bennett SJ Pressler ML Hays L	1997	Prog Jaarsma Cardiovasc Nurs1997，12，：	1
	6	Sulealeffacementonfluidattenuationinversionrecovermagneticresonanceim-aginginhyperacutestroke:asssociationwithcollateralflowandclinicaloutcomes显示文摘	KIM SJ HAYS RYOOS etal	2012	Stoke2012，43，1：	1
	7	Psychosocial variables and hospitalization in persons with chronic heart failure显示文摘	Bennett SJ Pressler ML Hays L	1997	Prog Cardiovasc Nurs1997，12，：	1

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