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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Water quality in mountain ash forests - separating the impacts of roads from those of logging operations显示文摘 | Grayson R B Haydon S R Jayasuriya M D A | 1993 | Journal of Hydrology1993，150，2： | 1 |
| 3 | Dynamic signaling between astrocytes显示文摘 | Carmignoto G Haydon PG | 2001 | Annu Rev Physiol2001，63，： | 1 |
| 4 | Effect of physical activity and body size on survival after diagnosis with colorectal cancer显示文摘 | HAYDON A MACINNIS R J ENGLISH D R | 2006 | Gut2006，55，1： | 1 |
| 5 | Phosphorus and the roles of productivity and nutrient recycling during oceanic anoxic event 2 显示文摘 | Haydon P M Thierry A Karl B F | 2007 | Geology2007，35，6： | 1 |
| 6 | The generation and persistence of genetic variation in foot-and-mouth disease virus 显示文摘 | Haydon D T Samuel A R Knowles N J | 2001 | Prev Vet Med2001，51，： | 1 |
| 7 | Interactions between plant circadian clocks and solute transport 显示文摘 | HAYDON M J BELL L J WEBB A A R | 2011 | Journal of Experimental Botany2011，62，7： | 1 |
| 8 | The generation and persistence of genetic variation in foot and mouth disease virus显示文摘 | Haydon D T Samuel A R Knowles N J | 2001 | Prev Vet Med2001，51，： | 1 |
| 9 | Pattern does not equal process:What does patch occupancy really tell us about metapopulation dynamics显示文摘 | Clinchy M Haydon D T Smith A T | | 0，，04： | 1 |
| 10 | Cytoplasmic and/ or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma 显示文摘 | Haydon RC Deyrup A Ishikawa A | 2002 | Int J Cancer2002，102，4： | 1 |
| 11 | Cytoplasmic and/or nu clear accumulation of the beta-catenin protein is a frequent event in human osteosareoma 显示文摘 | Haydon RC Deyrup A Ishikawa A | 2002 | Int J Cancer2002，102，4： | 1 |
| 12 | Adjuvant chemotherapy in colon cancer: what is the evidence显示文摘 | HAYDON A | 2003 | Inter Med J2003，33，： | 1 |
| 13 | The genera-tion and persistence of genetic variation in foot-and-mouthdisease virus显示文摘 | HAYDON D T SAMUEL A R KNOWLES N J | 2001 | Prev Vet Med2001，51，12： | 1 |
| 14 | Adenosine released by astrocytes contributes to hypoxia-induced modulation of synaptic transmission显示文摘 | Martín ED Fernández M Perea G Pascual O Haydon PG Araque A | 2007 | Glia2007，55，1： | 1 |
| 15 | Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma 显示文摘 | Deyrup A Ishikawa A | 2002 | Int J Cancer2002，102，4： | 1 |
| 16 | Molecular analysis of the 793/B serotype of infectious bronchitis virus in Great Britain显示文摘 | Adzhar A Gough R E Haydon D | 1997 | Avian Pathol1997，26，： | 1 |
| 17 | Cytoplasmic and/or nuclear accumulation of the bate-catenin protein is a frequent event in human osteosaroma显示文摘 | Haydon R C Deyrup A Ishiawa A | 2002 | Int J Cancer2002，102，4： | 1 |
| 18 | Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma显示文摘 | HAYDON RC DEYRUP A ISHIKAWA A | 2002 | Int J Cancer2002，102，4： | 1 |
| 19 | Dynamic Signaling between Neurons and Glia显示文摘 | ARAQUE A CARMIGNOTO G HAYDON PG | 2001 | Annu Rev Physiol(S0066-4278)2001，63，： | 1 |
| 20 | The tripartite synapse- glia in synaptic transmission 显示文摘 | Voherra A Magistretti P J Haydon PG | 2003 | J Neurol2003，250，： | 1 |
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