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| 1 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 2 | 循证实践中的医患选择——医疗决策不能迷信证据而要靠人显示文摘 | R Brain Haynes PJ Devereaux Gordon H Guyatt 陈霖 | 2003 | 中国循证医学杂志2003，3，4： | 7 |
| 3 | Relative quantification of phosphoproteomic changes in grapevine (Vitis vinifera L.) leaves in response to abscisic acid显示文摘In a previous transcriptomic analysis,abscisic acid(ABA)was found to affect the abundance of a number of transcripts in leaves of Cabernet Sauvignon grapevines with roots that had been exposed to 10μM ABA for 2 h.Other work has indicated that ABA affects protein abundance and protein phosphorylation as well.In this study we investigated changes in protein abundance and phosphorylation of Cabernet Sauvignon grapevine leaves.Protein abundance was assessed by both label-free and isobaric-label quantitive proteomic methods.Each identified common proteins,but also additional proteins not found with the other method.Overall,several thousand proteins were identified and several hundred were quantified.In addition,hundreds of phosphoproteins were identified.Tens of proteins were found to be affected in the leaf after the roots had been exposed to ABA for 2 h,more than half of them were phosphorylated proteins.Many phosphosites were confirmed and several new ones were identified.ABA increased the abundance of some proteins,but the majority of the proteins had their protein abundance decreased.Many of these proteins were involved in growth and plant organ development,including proteins involved in protein synthesis,photosynthesis,sugar and amino-acid metabolism.This study provides new insights into how ABA regulates plant responses and acclimation to water deficits. | Supakan Rattanakan Iniga George Paul A Haynes Grant R Cramer | 2016 | Horticulture Research2016，3，1： | 3 |
| 4 | 临床诊断的证据基础 诊断性研究的构想显示文摘人们已经付出了很大的努力来研究临床医学和科学方法之间的相互关系,以使诊断性试验最有效、最实用。本文重点讨论在诊断性研究中出现的特殊类型的问题以及用以解决上述问题的研究构想(将这些临床问题转化成适当的研究计划)。举一个例子,我们将评价一下脑钠素(BNP) | D L Sackett R B Haynes 陈雷 | 2003 | 英国医学杂志中文版2003，6，3： | 2 |
| 5 | Complement factor H polymorphism in age-related macular degeneration显示文摘 | Klein R J Zeiss C Chew E Y Tsai J Y Sackler R S Haynes C | 2005 | Science2005，308，： | 1 |
| 6 | Tuberculous pleural effusion:twenty 2 year experience显示文摘 | Siebert AF Haynes JJr Middleton R | 1991 | Chest1991，99，： | 1 |
| 7 | Concrete deterioration from physical attack by salts 显示文摘 | Haynes H O’Neill R Mehta P K | 1996 | Concr Int1996，18，1： | 1 |
| 8 | Target isolation for SAR images显示文摘 | Xu R Kwan C M Haynes L S | 2001 | Proceedings of SPIE2001，4382，： | 1 |
| 9 | Some effects of orchards soil management on sward composition levels of available nutrients in the soil and leaf nutrient content of nature 'Golden Delicious' apple trees显示文摘 | Haynes R J K M Goh | 1980 | SciHort1980，13，： | 1 |
| 10 | Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats显示文摘 | Fu WJ Haynes TE Kohli R | 2005 | J Nutr2005，135，4： | 1 |
| 11 | Competitive aspects of the grass-legume association显示文摘 | Haynes R J | 1980 | Advances in Agronomy1980，33，： | 1 |
| 12 | Failure of femoral head fixation:a cadaveric analysis of lag screw cut-out with the gamma locking nail and AO dynamic hip screw显示文摘 | Haynes R C Poll R G Miles A W | | 0，，5： | 1 |
| 13 | Systematic reviews: synthesis of best evidence for clinical decisions 显示文摘 | COOK D J MULROW C D HAYNES R B | 1997 | Aim Intern Med1997，126，5： | 1 |
| 14 | Salt weathering distress on concrete exposed to sodium sulfate environment 显示文摘 | Haynes H O’Neill R Neff M | 2008 | J ACI Mater2008，105，1： | 1 |
| 15 | Dietary L-arginine supplementation enhances endothelial nitric oxide synthesis in streptozotocin-induced diabetic rats显示文摘 | Kohli R Meininger CJ Haynes TE | 2004 | J Nutr2004，134，3： | 1 |
| 16 | Nanosphere lithography: tunable localized surface plasmon resonance spectra of silver nanoparticles显示文摘 | Jensen T R Malinsky M D Haynes C L | 2000 | Journal of Physical Chemistry B2000，104，10： | 1 |
| 17 | Magnetic anisotropy of Co^2+ as signature of intrinsic ferromagnetism in ZnOCo显示文摘 | Sati P Hayn R Kuzian R | 2006 | Phys Rev Letts2006，96，01： | 1 |
| 18 | Salt weathering of concrete by sodium carbonate and sodium chloride 显示文摘 | Haynes H O’Neill R Neff M | 2010 | J ACI Mater2010，107，25： | 1 |
| 19 | A surgical safety checklist to reduce morbidity and mortality in a global population显示文摘 | Haynes A B Weiser T G Berry W R | 2009 | N Engl J Med2009，360，5： | 1 |
| 20 | Patient compliance and theconduct and interpretation of therapeutic trials显示文摘 | Haynes R B Dantes R | 1987 | Control Clin Trials1987，8，1： | 1 |
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