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| 1 | Enzyme inhibition assay for pyruvate dehydrogenase complex: Clinical utility for the diagnosis of primary biliary cirrhosis显示文摘Primary biliary cirrhosis (PBC) is usually diagnosed by the presence of characteristic histopathological features of the liver and/or antimitochondrial antibodies (AMA) in the serum traditionally detected by immunofluorescence. Recently, new and more accurate serological assays for the detection of AMA, such as enzyme-linked immunosorbent assay (ELISA), immunoblotting, and enzyme inhibition assay, have been developed. Of these, the enzyme inhibition assay for the detection of anti-pyruvate dehydrogenase complex (PDC) antibodies offers certain advantages such as objectivity, rapidity, simplicity, and low cost. Since this assay has almost 100% specificity, it may have particular applicability in screening the at-risk segment of the population in developing countries. Moreover, this assay could be also used for monitoring the disease course in PBC. Almost all sera of PBC-suspected patients can be confirmed for PBC or non-PBC by the combination results of immunoblotting and enzyme inhibition assay without histopathological examination. For the development of a 'complete' or 'gold standard' diagnostic assay for PBC, similar assays of the enzyme inhibition for anti-2-oxoglutarate dehydrogenase complex (OGDC) and anti-branched chain oxo-acid dehydrogenase complex (BCOADC) antibodies will be needed in future. | Katsuhisa Omagari Hiroaki Hazama Shigeru Kohno | 2005 | World Journal of Gastroenterology2005，11，43： | 5 |
| 2 | Th2 subset dominance a- mong peripheral blood T lymphocytes in patients with digestive canc- ers显示文摘 | Tabata T Hazama S Yoshino S | 1999 | Am J Surg1999，177，3： | 1 |
| 3 | nm23-H1 gene as a molecular switch between the free-floating and dherent atates of gastric cancer cells显示文摘 | Iizuka N Tangoku A Hazama S | 2001 | Cancer Lett2001，174，1： | 1 |
| 4 | Immunological analysis and clinical effects of intraabdominal and intrapleural injection of lentinan for malignant ascites and pleural effusion显示文摘 | OKa M Yoshino S Hazama S | 1992 | Biotherapy1992，5，2： | 1 |
| 5 | Expression of estrogen receptor-alpha and -beta mRNAs in human gastric cancer显示文摘 | Takano N Iizuka N Hazama S | 2002 | Cancer Lett2002，176，2： | 1 |
| 6 | Anticachectic effects of the natural herb coptidis rhizome and berberine on mice bearing colon 26/clone 20 adenocarcinoma显示文摘 | Lizuka N Hazama S Yoshimura K | 2002 | Int J Cancer2002，99，： | 1 |
| 7 | Beneficial ef- fects of nateglinide on insulin resistance in type 2 dia- betes 显示文摘 | Hazama Y Matsuhisa M Ohtoshi K | 2006 | Diabetes Res Clin Pract2006，71，3： | 1 |
| 8 | Beneficial effects of nateglinide on insulin resistance in type 2 diabetes显示文摘 | HAZAMA Y MATSUHISA M OHTANI K | 2006 | Diabetes Care2006，29，： | 1 |
| 9 | nm23-H1 gene as a molec- ular swith between the free-flvating and adherent stats of gastric cancer cells显示文摘 | Iizuka N Tangoku A Hazama S | 2001 | Cancer Letter2001，174，1： | 1 |
| 10 | Drug meabolixing activitiy in rats with chronic liver injury induced by carbontetracholride:relation-ship with the content of hydroxyproline in the liver显示文摘 | Okuno H Hazama H Murase T | 1986 | J Pharmacol1986，41，： | 1 |
| 11 | Voglibose,an alphaglucosidase inhibitor,to increase active glucagon-like peptide-1 levels 显示文摘 | MORITOH Y TAKRUCHI K HAZAMA M | 2009 | Mol Cell Pharmacol2009，1，4： | 1 |
| 12 | Suppressive effects of cyclophosphamide and gemcitabine on regulatory T-cell induction in vitro 显示文摘 | Kan S Hazama S Maeda K | 2012 | Anticancer Res2012，32，12： | 1 |
| 13 | Rare-earth- based alloy electrodes for an nickel-metal hydride bat- tery显示文摘 | Sakai T Hazama T Miyamura H | 1991 | Journal of the Less Common Metals1991，，： | 1 |
| 14 | Endothelin-1 and vasopression activate Ca(2+)-permeable non-selective cation channels in aortic smooth muscle cells:mechenism of receptor mediated Ca2+ influx显示文摘 | Nakajima T Hazama H Hamada E | 1996 | J Mol Cell Cardiol1996，28，4： | 1 |
| 15 | Volume-regulatory ion channels in epithelial cells显示文摘 | Okada Y Hazama A | 1989 | News physiol sci1989，4，： | 1 |
| 16 | Validation of Body Composition Assessed by Bioelectrical Impedance Analysis显示文摘 | Nakadomo F Tanaka K Hazama T | 1990 | Jpn J Appl Physiol1990，20，： | 1 |
| 17 | Brain-derived neurotrophic factor regulates cholesterol metabolism for synapse development显示文摘 | Suzuki S Kiyosue K Hazama S | 2007 | J Nueroscience2007，27，24： | 1 |
| 18 | Immunohistochemical characterization of glomerular PDGF B-chain and PDGF beta-receptor expression in diabetic rats显示文摘 | Nakagawa H Sasahara M Haneda M Koya D Hazama F Kikkawa R | 2000 | Diabetes Res Clin Pract2000，48，： | 1 |
| 19 | Interleukin-1 receptor antagonist mRNA expression and the progression of gastric carcinoma显示文摘 | Iizuka N Hazama S Hirose K | 1999 | Cancer Lett1999，142，2： | 1 |
| 20 | Potent ectopic bone-inducing activity of bone morphogenetic protein-4/7 heterodimer显示文摘 | AONO A HAZAMA M NOTOYA K | 1995 | Biochem Biophys Res Commun1995，210，3： | 1 |
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