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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | An effective co-evolutionary particle swarm optimization for constrained engineering design problems显示文摘 | He Q Wang L | 2007 | Engineering Applications of Artificial Intelligence2007，20，1： | 1 |
| 3 | Cyanea capillata tentacle-only extract as a potential alternative of nematocyst venom:its cardiovascular toxicity and tolerance to isolation and purification procedures显示文摘 | Xiao L He Q Guo Y | 2009 | Toxicon2009，53，1： | 1 |
| 4 | Concentration of thymidinekinase l in serum(S-TKI)is a more sensitive proliferationmaker in human solid tumors than its activity显示文摘 | He Q Zou L Zhang PA | 2005 | Oncol Rep2005，14，4： | 1 |
| 5 | An alternative paclitaxel microemulsion formulation:hypersensitivity evaluation and pharmacokinetic profile显示文摘 | He L Wang GL Zhang Q | 2003 | Int J Pharm2003，250，1： | 1 |
| 6 | TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance显示文摘 | HE W LIU Q WANG L | 2007 | Mol Immunol2007，44，11： | 1 |
| 7 | Synthesis and antitumor activity of novel α-aminophosphonates from diterpenic dehydroabietylamine 显示文摘 | RAO X P SONG Z Q HE L | 2008 | Heteroatom Chemistry2008，19，5： | 1 |
| 8 | Mechanical properties of single crystal tungsten microwhiskers characterized by nanoindentation 显示文摘 | HUANG H WU Y Q WANG S L HE Y H ZOU J HUANG B Y LIU C T | 2009 | Materials Science and Engeering A2009，53，12： | 1 |
| 9 | 3D numerical simulation on shell-and-tube heat exchangers with middle-overlapped helical baffles and continuous baffles-Part II : Simulation results of periodic model and comparison between continuous and noncontinuous helical baffles显示文摘 | Zhang J F He Y L Tao W Q | 2009 | International Journal of Heat and Mass Transfer2009，52，2324： | 1 |
| 10 | Experimental study on the performance of CO2 residential air-conditioning system with anInternal heat exchanger显示文摘 | Tao Y B He Y L Tao W Q Wu Z G | | 0，，01： | 1 |
| 11 | 查看详情显示文摘 | Zhang J P Yang H P Han K L Deng W Q He G Z Lou N Q | | 0，，： | 1 |
| 12 | Microstructure difference between core and skin of T700 carbon fibers in heat-treated carbon/carbon composites显示文摘 | Zhou G S Liu Y Q He L L | 2011 | Carbon2011，49，9： | 1 |
| 13 | Emergence, circulation, and spatiotemporal phylogenetie analysis of eoxsaekievirus a6 - and coxsackievirus al0 - associated hand, foot, and mouth disease infections from 2008 to 2012 in shenzhen, china显示文摘 | He Y Q Chen L Xu W B | 2013 | J Clin Microbiol2013，51，11： | 1 |
| 14 | Draft genome sequence of Streptom?-ces globisporus C- 1027, which produces an antitumor antibiotic consisting of a nine-membered enediyne with a chromoprotein 显示文摘 | Wang L F Wang S M He Q | 2012 | J Bacteriol2012，194，15： | 1 |
| 15 | A mixed microscopic meth- od for differentiating seven species of 'Bixie' -related Chinese ma- teria medica显示文摘 | Tang Y N He X C Chen Q L | 2014 | Microsc Res Tech2014，77，1： | 1 |
| 16 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 17 | High Pressure-Temperature Brillouin Study of Liquid Water: Evidence of the Structural Transition from Low-Density Water to High-Density Water 显示文摘 | Li F F Cui Q L He Z | 2005 | J Chem Phys2005，123，17： | 1 |
| 18 | Further improvement of free- weighting matrices technique for systems with time-varying delay 显示文摘 | He Y Wang Q G Xie L H | 2007 | IEEE Transactions on Automatic Control (S0018-9286)2007，53，2： | 1 |
| 19 | Sorting efficiency and combustion properties of municipal solid waste during bio-drying 显示文摘 | Zhang D Q He P J Shao L M | 2009 | Waste Management2009，29，11： | 1 |
| 20 | Deposition of large area high quality diamond wafers with high growth rate by DC arc plasma jet 显示文摘 | H Guo Z L Sun Q Y He | 2000 | Diamond and Related Materials2000，，9： | 1 |
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