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| 1 | Influence of irritable bowel syndrome on treatment outcome in gastroesophageal reflux disease显示文摘AIM: To investigate the influence of irritable bowel syndrome (IBS)-like symptoms on treatment outcomes with pantoprazole in gastroesophageal reflux disease (GERD) in a real life setting. METHODS: For this prospective, open-label, multinational, multicentre study, 1888 patients assessed by the investigators as suffering from GERD were recruited. The patients were additionally classified as with or without IBS-like symptoms at baseline. They were treated with pantoprazole 40 mg once daily and completed the Reflux Questionnaire (ReQuest) short version daily. Response rates and symptom scores were compared after 4 and 8 wk of treatment for subgroups defined by the subclasses of GERD [erosive(ERD) and non-erosive reflux disease (NERD)] and the presence of IBS-like symptoms. RESULTS: IBS-like symptoms were more prevalent in NERD than in ERD (18.3% vs 12.7%, P = 0.0015). Response rates after 4 and/or 8 wk of treatment were lower in patients with IBS-like symptoms than in patients without IBS-like symptoms in both ERD (Week 4: P < 0.0001, Week 8: P < 0.0339) and NERD (Week 8: P = 0.0088). At baseline, ReQuest 'lower abdominal com- plaints' symptom scores were highest in NERD patients with IBS-like symptoms. Additionally, these patients had the strongest symptom improvement after treatment compared with all other subgroups. CONCLUSION: IBS-like symptoms influence treatment outcome and symptom burden in GERD and should be considered in management. Proton pump inhibitors can improve IBS-like symptoms, particularly in NERD. | Hubert Mnnikes Robert C Heading Holger Schmitt Hubert Doerfler | 2011 | World Journal of Gastroenterology2011，17，27： | 4 |
| 2 | Attracting foreign manufacturing: investment promotion and agglomeration 显示文摘 | Head C K Ries J C Swenson D L | 1999 | Regional Science and Urban Economics1999，29，2： | 1 |
| 3 | Tectonic evolution of the terrestrial plan- ets显示文摘 | Head J W Solomon S C | 2009 | Science2009，213，： | 1 |
| 4 | Lamina propria replacement therapy with cultured autologous fibroblasts for vocal fold scars显示文摘 | CHHETRI D K HEAD C REVAZOVA E | 2004 | Otolaryngol Head Neck Surg2004，131，： | 1 |
| 5 | Brain function in Duch- enne muscular dystrophy 显示文摘 | Anderson JL Head SI Rae C Morley JW | 2002 | Brain2002，125，： | 1 |
| 6 | Dysregulated immune system in children with autism:beneficial effects of intravenous immune globulin on autistic characteristics显示文摘 | Gupta S Aggarwal S Heads C | 1996 | J Autism Dev Disord1996，26，4： | 1 |
| 7 | Attracting foreign manufacturing:investment promotion and agglomeration 显示文摘 | Head C K Ries J C Swenson D L | 1999 | Regional Science and Urban Economics1999，29，： | 1 |
| 8 | Tape-red design for the cementless total hip arthroplasty femoral component显示文摘 | MALLORY T H HEAD W C LOMBARDI AV J R | | 0，，344： | 1 |
| 9 | Cry1Ab protein levels in phytophagons insects feeding on tnmsgenie corn: implications for secondary exposure risk assessment 显示文摘 | HEAD G BROWN C R CROTH M E | 2001 | Entomologia Expermentalis et Applicata2001，99，： | 1 |
| 10 | Prostaghndin (PG) modulation of bradykinin-induced hyperalgesia and edema in the guinea pig paw effects of PGD2,PGE2,and PGI2显示文摘 | Whelan C J Head SA Poll CT | 1991 | AgantsActions Suppl 19911991，，： | 1 |
| 11 | Differences in virulence between two Candida albicans strains in experimental keratitis显示文摘 | O Day DM Head WS Csank C | 2000 | Invest Ophthalmol Vis Sci2000，41，5： | 1 |
| 12 | Public goods,private goods,and ambiguous goods显示文摘 | Head J G Shoup C S | 1969 | Economic Journal1969，79，315： | 1 |
| 13 | Jet engine compute aided tube design system显示文摘 | Jones D C Head C D Crupi J | 1979 | The American Society of Mechanical Engineers1979，36，8： | 1 |
| 14 | Palliative nursing care of the pa- tient with cancer-related fatigue显示文摘 | Keeney C E Head B A | 2011 | Journal of Hospice Palliative Nursing2011，13，5： | 1 |
| 15 | Simultaneous measurement of gastric emptying of a solid meal by ultrasound and by scintigraphy 显示文摘 | Sembenini C Heading RC Giorgetti RG Montemenzzi S Zamboni M Di Benedetto P Brighenti F Vantini I | 1999 | Am J Gastroenterol1999，94，10： | 1 |
| 16 | The important role of infrared imaging in breast cancer 显示文摘 | Head J F Wang F Lipari C | 2000 | IEEE Eng Med Bio2000，19，3： | 1 |
| 17 | Restoration of Bone Stock in Revision Surgery of the Femur显示文摘 | Head W C Malinin T I Emerson R H | 2000 | Int Orthop2000，24，1： | 1 |
| 18 | Can social support protect bullied adolescents from adverse outcomes:a prospective study on the effects of bullying on the educational achievement and mental health of adolescents at secondary schools in East London显示文摘 | Rothon C Head J Klineberg E | 2011 | J Adolesc2011，34，3： | 1 |
| 19 | A computational model for biofilm-based microbial fuel cells显示文摘 | Picioreanu C Head IM Katuri KP | 2007 | Water Res2007，41，13： | 1 |
| 20 | Lunar regional dark mantle deposits:Geologic,multispectral,and modeling studies显示文摘 | Weitz C M Head J W Pieters C M | 1998 | Journal of Geophysical Research:Planets1998，103，22： | 1 |
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