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| 1 | 策略将在肝移植以后减少丙肝病毒复发显示文摘 Hepatitis C virus (HCV) is a major health problem that leads to chronic hepatitis, cirrhosis and hepatocellular carcinoma, being the most frequent indication for liver transplantation in several countries. Unfortunately, HCV re-infects the liver graft almost invariably following reperfusion, with an accelerated history of recurrence, leading to 10%-30% of patients progressing to cirrhosis within 5 years of transplantation. In this sense, some groups have even advocated for not retransplanting this patients, as lower patient and graftoutcomes have been reported. However, the management of HCV recurrence is being optimized and several strategies to reduce post-transplant recurrence could improve outcomes, decrease the rate of re-transplantation and optimize the use of available grafts. Three moments may be the focus of potential actions in order to decrease the impact of viral recurrence: the pretransplant moment, the transplant environment and the post-transplant management. In the pre-transplant setting, it is not well established if reducing the pre transplant viral load affects the risk for HCV progression after transplant. Obviously, antiviral treatment can render the patient HCV RNA negative post transplant but the long-term benefit has not yet been fully established to justify the cost and clinical risk. In the transplant moment, factors as donor age, cold ischemia time, graft steatosis and ischemia/reperfusion injury may lead to a higher and more aggressive viral recurrence. After the transplant, discussion about immunosuppression and the moment to start the treatment (prophylactic, pre-emptive or once-confirmed) together with new antiviral drugs are of interest. This review aims to help clinicians have a global overview of posttransplant HCV recurrence and strategies to reduce its impact on our patients. | Ruben Ciria María Pleguezuelo Shirin Elizabeth Khorsandi Diego Davila Abid Suddle Hector Vilca-Melendez Sebastian Rufian Manuel de la Mata Javier Briceo Pedro López Cillero Nigel Heaton | 2013 | World Journal of Hepatology2013，5，5： | 2 |
| 2 | Finite sample properties of some alternative GMM estimators 显示文摘 | Hansen L P Heaton J Yaron A | 1996 | Journal of Business & Economic Statistics1996，14，3： | 1 |
| 3 | Strategies for the engineered phytoremediation of toxic element pollution:Mercury and arsenic显示文摘 | MEAGHER R B HEATON A C | 2005 | Indust rial microbiology and biotechnology2005，32，1112： | 1 |
| 4 | The characterization of a bio-assay of erectile function in a rat model 显示文摘 | Heaton JP Varrin S J Morales A | 1991 | J Urol1991，145，5： | 1 |
| 5 | Predicting the crystallization potential of urine from cats and dogs with respect to calcium oxalate and magnesium ammonium phosphate (struvite) 显示文摘 | Robertson W G Jones J S Heaton M A | 2002 | Journal of Nutrition2002，32，16： | 1 |
| 6 | Transient overvoltages on power systems显示文摘 | Bickford J P Heaton A G | 1986 | IEE Proceedings1986，133，4： | 1 |
| 7 | Full Stokes polarimeter for characterization of fiber optic gyroscope coils显示文摘 | Lompado A Reinhardt J C Heaton L C | 2009 | Optics Express2009，17，10： | 1 |
| 8 | Strategies for the engineered phy-toremediation of toxic element pollution: mercury and arsenic 显示文摘 | MEAGHER R B HEATON A C | 2005 | In-dustrial Microbiology and Biotechnology2005，32，1112： | 1 |
| 9 | Effect of temperature,illumination and node position on stem propagation of Miseanthus X giganteus显示文摘 | Boersma N N Heaton E A | 2012 | GCB Bioenergy2012，4，： | 1 |
| 10 | Clinical use of hyaluronic acid as a predictor of fibrosis in hepatitis C显示文摘 | Patel K Lajoie A Heaton S | 2003 | J Gastroenterol Hepatol2003，18，3： | 1 |
| 11 | Escherichia coli heat -labile enterotoxin B subunit prevents autoimmune arthritis through induction of regulatory CD+4 T cells显示文摘 | Luross J A Heaton T Hirst T R | 2002 | Arthritis Rheum2002，46，6： | 1 |
| 12 | Miscanthus for renewable energy generation: European Union experience and projections for Illinois显示文摘 | Heaton E A Clifton-Brown J Voigt B | 2004 | Mitigation and Adapation Strategies for Global Change2004，9，： | 1 |
| 13 | The characterization of a bio-assay of erectile function in a rat model显示文摘 | Heaton JP Varrin SJ Morales A | 1991 | J Urol1991，145，5： | 1 |
| 14 | Gaseous nitrogen as evidence for denitrification in groundwater显示文摘 | Vogel J C Talma A S Heaton T H E | 1981 | J Hydrol1981，50，： | 1 |
| 15 | Physical map of the genome of sonchus yellow net virus,a plant rhabdovirus with six genes and conserved gene junction sequences显示文摘 | Heaton L A Hillman B I Hunter B G | 1989 | Proceedings of the National Academy of Sciences of the United States of America1989，86，22： | 1 |
| 16 | Comparison of reversed-phase and hydrophilic interaction liquid chromatography for the quantification of ephedrines using medium-resolution accurate mass spectrometry显示文摘 | GRAY N HEATON J MUSENGA A | 2013 | Journal of Chromatography A2013，1289，： | 1 |
| 17 | The characterization of a bioassay of erectile function in a rat model显示文摘 | Heaton JP Varrin SJ Morales A | 1991 | J Urol1991，145，5： | 1 |
| 18 | Escherichia coli heat-labile enterotoxin B subunit prevents autoimmune arthritis through induction of regulatory CD4+ T cells显示文摘 | Luross J A Heaton T Hirst T R | 2002 | Arthritis Rheum2002，46，6： | 1 |
| 19 | Assessment of potential donors for living related liver transplantation显示文摘 | BAKER A Dhawan A Devlin J Mieli-Vergani G. O Grady J. Williams R Rela M. Heaton N | | 0，，： | 1 |
| 20 | Simulating the effects of Glen Canyon Dam releases on Grand Canyon Riv- er Trips 显示文摘 | Ronald E Boric Heaton Underhill A | 1989 | Environmental Management1989，13，3： | 1 |
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