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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Ten species in one:DNA barcoding reveals cryptic species in the Neotropical skipper butterfly Astraptes fulgerator显示文摘 | HEBERT P D N PENTON E H BURNS J M | 2004 | Proc Natl Acad Sci2004，101，14： | 1 |
| 3 | Barcoding animal life : cytechmme c oxidase subunit 1 divergences among closely related species 显示文摘 | Hebert P D N Ratnasingham S de Waard J R | 2003 | Proceedings of the Royal Society of London B : Biolocal Sciences2003，270，1： | 1 |
| 4 | Genome organization of the Kres- se strain of porcine parvovirus: Identification of the allotropic de- terminant and comparison with those of NADL-2 andfield isolates 显示文摘 | Bergeron J Hebert B Tijssen P | 1996 | Virol1996，70，： | 1 |
| 5 | Migraine and subsequent risk of stroke in the Physician's Health Study显示文摘 | Buring J E Hebert P Romero J | 1995 | Arch Neurol1995，52，2： | 1 |
| 6 | Bar coding animal life:Cytoehrome c oxidase subunit 1 di vergences among closely related species显示文摘 | Hebert P D N Ratnasingham S de Waard J R | 2003 | Proceed ings of the Royal Society of London Series B:Biologi cal Sciences2003，270，： | 1 |
| 7 | Implementation of functional autonomy measurement system: barriers and facilitators in PISE-Dordogne project显示文摘 | Gervais P Hebert R Lamontagne J | 2011 | Geriatric et psychol- ogic neuropsychiatrie du vieillissement2011，9，： | 1 |
| 8 | Barcoding animal life: cytochrome c oxidase subunit 1 divergences among closely related species 显示文摘 | Hebert P D N Ratnasingham S Dewaard J R | 2003 | Proc R Soc Lond B ( Suppl )2003，270，： | 1 |
| 9 | Biogeography of a widespread freshwater crustacean: pseudocongruence and cryptic endemism in the North American Daphnia laevis complex显示文摘 | TAYLOR D J FINSTON T L HEBERT P N D | 1998 | Evolution1998，52，6： | 1 |
| 10 | Genome organization of the Kresse strain of porcine parvovirus: identification of the allotropic determinant and comparison with those of NADL-2 and field isolates 显示文摘 | Bergeron J Hebert Band Tijssen P | 1996 | ViroL1996，70，4： | 1 |
| 11 | Barcoding animal life:cytochrome coxidase subunit 1 divergences among closely related species显示文摘 | Hebert P D Ratnasingham S Waard J R | 2003 | Proc Biol Sci2003，270，1： | 1 |
| 12 | Modulation of lens epithelial cell proliferation by enhanced pros- taglandin synthesis after UVB exposure 显示文摘 | Andley U P Hebert J S Morrison A R | 1994 | Invest Ophthalmol Vis Sci1994，35，2： | 1 |
| 13 | Barcoding animal life: cytochrome coxidase subunit 1 divergences among closely related species 显示文摘 | Hebert P D N Ratnasingham S de Ward J R | 2003 | Proc R Soc B Biol Sci2003，270，1： | 1 |
| 14 | Genome organization of the Kresse strain of porcine parvovirus: identification of the allotropic determinant and comparison with those of NADL-2 and field isolates显示文摘 | Bergeron J Hebert B Tijssen P | 1996 | J Virol1996，70，4： | 1 |
| 15 | Ten species in one:DNA barcoding reveals cryptic species in the neotropical skipper butterfly Astraptes fulgerator显示文摘 | Hebert P D N Penton E H Burns J M | 2004 | Proc Natl Acad Sci USA2004，101，14： | 1 |
| 16 | Barcoding animal life: cytochrome c oxidase subunit 1 divergences among closely related species 显示文摘 | Hebert P D N Ratnasingham S Waard J R | 2003 | Proc R Soc Eond Ser B2003，270，1： | 1 |
| 17 | Alzheimer disease in the US population: prevalence estimates using the 2 000 cen- sus 显示文摘 | Hebert L E Scherr P A Bienias J L | 2003 | Arch Neurol2003，60，8： | 1 |
| 18 | Effects of chemical contaminants on genetic diversity in natural populations: implications for biomonitoring and ecotoxicology显示文摘 | BICKHAM J W SANDHU S HEBERT P D N | 2000 | Mutation Research2000，463，： | 1 |
| 19 | The 15% solution for preservation显示文摘 | Taylor D J Finston T L Hebert P D N | 1994 | Trends Ecol Evol1994，9，6： | 1 |
| 20 | Genome organization of the Kresse strain of porcine parvovirus:identification of the allotropic determinant and comparison with those of NADL-2 and field isolates显示文摘 | Bergeron J Hebert B Tijssen P | 1996 | J Virol1996，70，4： | 1 |
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