维普期刊资源整合服务平台（V6.5）

87篇 您的检索式：作者名="Hehrlein"

选中清除导出查看参考文献查看引证文献引用追踪共5页首页上一页第1页下一页末页 /5 跳转

	题名	作者	年代	出处	被引量
1	Expression of the oxygen-sensitive transcription factor subunit HIF-1α in patients suffering from secondary Raynaud syndrome显示文摘Anti-ischemic therapy remains a challenge due to the complexity of hypoxia response pathways. Hypoxia-inducible factor (HIF)-1 is a heterodimer tran scription factor con sisti ng of 2 sub units, HIF-1α and HIF-1β. Hypoxia-depe ndent activatio n of HIF-1α regulates cellular 02 homeostasis. Raynaud syndrome (RS), as a comorbidity of the autoimmune disease systemic sclerosis (SS), is characterized by vasospasms that limit blood flow to the limbs, resulting in hypoxia. A single-center randomized study was con ducted to compare prostagla ndin E1 (PgEI) therapy with a treatme nt combi ning PgE1 and an en dotheli n-1 blocker, bosentan. A total of 30 patients suffering from SS with RS were enrolled. We examined the regulation of HIF-1α, its target heme oxygenase-1 (HMOX-1), and the serum levels of the HIF-1α protein in a subset of patients as well as in ten healthy individuals. The expression of HIF-1α and HMOX-1 in monocytes was measured using absolute plasmid-based quantitative real-time PCR, whereas serum HIF-1α levels were measured with ELISA. Samples were taken at the time of randomization and after 24 weeks. We found that HIF-1α and HMOX-1 mRNA expression in monocytes and serum HIF-1α protein levels were significantly higher in the SS/RS patients compared to the healthy control group. Single-drug therapy significantly increased HIF-1α and HMOX-1 mRNA expression in monocytes and serum HIF-1α protein levels in the SS/RS patients compared to those at the time of randomization, whereas combining PgE1 with an en dotheli n-1 blocker preve nted the further in creases in HIF-1α and HMOX-1 expressi on. We propose HIF-1α and HMOX-1 as novel markers for anti-ischemic therapy in RS.	Lukas Andreas Heger Mark Kerber Marcus Hortmann Samuel Robinson Maximilian Mauler Daniela Stallmann Daniel Duerschmied Christoph Bode Christoph Hehrlein Ingo Ahrens	2019	Acta Pharmacologica Sinica2019，40，4：	5
2	Two year follow-up after treatment of coronary in-stent restenosis with a paclitaxel-coated balloon catheter显示文摘	Bruno Scheller Christoph Hehrlein Wolfgang Bocksch Wolfgang Rutsch Dariush Haghi Ulrich Dietz Michael B?hm Ulrich Speck	2008	Clinical Research in Cardiology2008，，10：	2
3	A novel balloon angioplasty catheter impregnated with beta-particle emitting radioisotopes for vascular brachytherapy toprevent restenosis:first in vivo results显示文摘	Hehrlein C Kovacs A Wolf GK	2000	Eur Heart J2000，21，24：	1
4	Advantages and limitations of radioactive stents显示文摘	Hehrlein C Kubler W	1997	Semin Interv Cardiol1997，2，2：	1
5	Low-dose radioactive endovascular stentts prevent smooth muscle cell proliferation and neointimal hyperplasia in rabbits 显示文摘	Hehrlein C Gollan C Donges K	1995	Circulation1995，92，6：	1
6	Influence of surface texture and charge on the biocompatibility of endovascular stents显示文摘	Zimmerman M Metz J	1995	Coronary Artery Dis1995，6，：	1
7	紫杉醇涂层球囊导管治疗冠状动脉支架内再狭窄	Scheller B. Hehrlein C. Bocksch W. 马超	2007	世界核心医学期刊文摘(心脏病学分册)2007，0，4：	1
8	Initial results with a Gamma- Emitting (Pd103) radioisotope stent in a rabbit iliac overstretch injury model显示文摘	Fischell TA Hehrlein C Lauer MA	2000	Circulation2000，102，：	1
9	Low-dose radioactive endovascular stents prevent smooth muscle cell proliferation and neointimal hyperplasia in rabbits显示文摘	Gollan C Donges K	1995	Circulation1995，92，：	1
10	Pure β-partide-emirting stents inhabit neointimal formation in rabbits显示文摘	Stintz M Kinscherf R	1996	Circulation1996，93，：	1
11	The role of pericardiectomy in pericardial disorders显示文摘	HEHRLEIN F W MOOSDORF R PITTON M	1991	Eur Heart J1991，12，：	1
12	Radioactive coronary stent implantation inhibits neointimal proliferation in non atherosclerotic rabbits显示文摘	Zimmerman M Metz J	1993	Circulation1993，88，：	1
13	Pure β-Particle-emitting Stents InhibitNeointima Formation in Rabbits显示文摘	Hehrlein C Stintz M Kinscherf R	1996	Circulation1996，94，4：	1
14	Pure β-particle-emitting stents inhibit neointimal formation in rabbits显示文摘	Stintz M Kinscherf R	1996	Circulation1996，93，：	1
15	Incidence and pathogenesis of late aneurysm after patch graft aortoplasty for coarctation 显示文摘	HEHRLEIN FW MULCH J RAUTENBURG HW	1986	Thorac Cardiovasc Surg1986，92，：	1
16	Intraoperative evaluation of the functional significance of coronary collateral vessels in patients with coronary artery disease显示文摘	Flameng W Schwarz F Hehrlein FW	1978	Am J Cardial1978，42，2：	1
17	Treatment of coronary in-stent restenosis with a paclitaxel-coated balloon catheter显示文摘	Scheller B Hehrlein C Bocksch W	2006	N Engl J Med2006，355，20：	1
18	Pediatric heart transplantation for congenital heartdim and cardiomyopathy显示文摘	Hehrlein FW Nets H Moesdorf R	1990	AnnThorac Surg1990，52，1：	1
19	Pediatric heart transplantation for con- genital heart disease and cardiomyopathy 显示文摘	Hehrlein FW Netz H Moosdorf R	1991	Ann Thorac Surg1991，52，1：	1
20	Treatment of coronary in stent restenosis with a paclitaxel coated balloon catheter显示文摘	Scheller B Hehrlein C Bocksch W	2006	N Engl J Med2006，355，21：	1

返回顶部每页显示：

共5页首页上一页第1页下一页末页 /5 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示