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您的检索式：作者名="Helena Tomás"
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| 1 | Cytocompatible cellulose nanofibers from invasive plant species Agave americana L.and Ricinus communis L.:a renewable green source of highly crystalline nanocellulose显示文摘In this study,the fibers of invasive species Agave americana L.and Ricinus communis L.were successfully used for the first time as new sources to produce cytocompatible and highly crystalline cellulose nanofibers.Cellulose nanofibers were obtained by two methods,based on either alkaline or acid hydrolysis.The morphology,chemical composition,and crystallinity of the obtained materials were characterized by scanning electron microscopy(SEM)together with energy-dispersive X-ray spectroscopy(EDX),dynamic light scattering(DLS),X-ray diffraction(XRD),and Fourier transform infrared(FTIR)spectroscopy.The crystallinity indexes(CIs)of the cellulose nanofibers extracted from A.americana and R.communis were very high(94.1%and 92.7%,respectively).Biological studies evaluating the cytotoxic effects of the prepared cellulose nanofibers on human embryonic kidney 293 T(HEK293 T)cells were also performed.The nanofibers obtained using the two different extraction methods were all shown to be cytocompatible in the concentration range assayed(i.e.,0-500μg/mL).Our results showed that the nanocellulose extracted from A.americana and R.communis fibers has high potential as a new renewable green source of highly crystalline cellulose-based cytocompatible nanomaterials for biomedical applications. | Olga L.EVDOKIMOVA Carla S.ALVES Radenka M.KRSMANOVIC WHIFFEN Zaida O.RTEGA Helena TOMáS Joao R.ODRIGUES | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，6： | 0 |
| 2 | Polysaccharide-based nanomedicines for cancer immunotherapy:A review显示文摘Cancer immunotherapy is an effective antitumor approach through activating immune systems to eradicate tumors by immunotherapeutics.However,direct administration of“naked”immunotherapeutic agents(such as nucleic acids,cytokines,adjuvants or antigens without delivery vehicles)often results in:(1)an unsatisfactory efficacy due to suboptimal pharmacokinetics;(2)strong toxic and side effects due to low targeting(or off-target)efficiency.To overcome these shortcomings,a series of polysaccharide-based nanoparticles have been developed to carry immunotherapeutics to enhance antitumor immune responses with reduced toxicity and side effects.Polysaccharides are a family of natural polymers that hold unique physicochemical and biological properties,as they could interact with immune system to stimulate an enhanced immune response.Their structures offer versatility in synthesizing multifunctional nanocomposites,which could be chemically modified to achieve high stability and bioavailability for delivering therapeutics into tumor tissues.This review aims to highlight recent advances in polysaccharide-based nanomedicines for cancer immunotherapy and propose new perspectives on the use of polysaccharide-based immunotherapeutics. | Yujun Zeng Yufan Xiang Ruilong Sheng Helena Tomás João Rodrigues Zhongwei Gu Hu Zhang Qiyong Gong Kui Luo | 2021 | Bioactive Materials2021，6，10： | 3 |
| 3 | Development and challenges of cells-and materials-based tooth regeneration显示文摘Tooth defect and loss are common clinical diseases in stomatology.With the extension of life expectancy,there is an increasing demand for tooth tissue and whole tooth regeneration.Compared with traditional oral prosthetic treatment,tooth regeneration has unique advantages and has become one of the hotspots towards oral biomedical treatment.In this review,we discussed the development and challenges of tooth regeneration based on cells and materials,including tooth enamel,dentin,dental pulp,cementum,dentin-pulp complex,and the whole tooth regeneration,in order to provide a comprehensive,up-to-date,illustrative overview of tooth regeneration issues.The mechanisms of the regeneration were also summarized and discussed.Moreover,this review hints the future perspective and research direction of tooth regeneration in the challenging field of regenerative dentistry. | Zeyu Fu Yu Zhuang Jinjie Cui Ruilong Sheng Helena Tomás João Rodrigues Bin Zhao Xudong Wang Kaili Lin | 2022 | Engineered Regeneration2022，3，2： | 0 |
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