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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Patients undergoing infrainguinal bypass to treat atherosclerotic vascular disease are underprescribed cardioprotective medications: effect on graft patency, limb salvage, and mortality显示文摘 | Peter K Henke Susan Blackburn Mary C Proctor Jeri Stevens Debabrata Mukherjee Sanjay Rajagopalin Gilbert R Upchurch James C Stanley Kim A Eagle | 2004 | Journal of Vascular Surgery2004，，： | 2 |
| 3 | X-ray interactions: photabsorption, scattering, transmission, and reflection at E-50-30000 eV, Z=1-92显示文摘 | HENKE B L GULLIKSON E M DAVIS J C | 1993 | Atomic Data and Nuclear Tables1993，54，： | 2 |
| 4 | Co-expression of in-terleukin-2 to increase the efficacy of DNA vaccine-mediated protection in coxsackievirus B3-infected mice显示文摘 | Chiang C S Zell R | 2004 | Antiviral Res2004，64，： | 1 |
| 5 | Synergistic activity of chitinases and β-1,3-glucanases enchance fungal resistance in transgenic tomato plants显示文摘 | Jongedijk Erik Henk Tigelear Jeroen S C Van Roekel | 1995 | Euphytica1995，85，13： | 1 |
| 6 | Carbon nanotube single-electron transistors at room temperature显示文摘 | HENK W C POSTMA T T YAO Z | 2001 | Science2001，293，5527： | 1 |
| 7 | Blood hemoglobin level may affect radiosensitivity-preliminary results on acutely reacting normal tissues显示文摘 | Henke M Bechtold C Momm F | 2000 | Int J Radiat Oncol Bid Phys2000，48，2： | 1 |
| 8 | X-ray interactions: photoabsorption scattering, transmission and reflection at E=50-30000 eV, Z=1-92显示文摘 | HENKE B L GULLIKSON E M DAVIS J C | 1993 | Atomic Data and Nuclear Data Tables1993，54，： | 1 |
| 9 | X-ray interaction:photoabsorption,scattering,transmission and reflection at E=50-30000eV,Z=1-92显示文摘 | HENKE B L GULLIKSEN E M DAVIS J C | 1993 | Atomic Data and Nuclear Data Tables1993，54，2： | 1 |
| 10 | Does Aller-genspecific immunotherapy represent a thdrapeutic option for patients with atopic dermatitis? 显示文摘 | Bussmann C Bockenhoff A Henke H | 2006 | Allerty clin Immunol2006，118，6： | 1 |
| 11 | X-ray interactions: photoabsorption, scattering, transmission, and reflection at E=50-30 000 eV, Z= 1-92显示文摘 | HENKE B L GULLIKSON E M DAVIS J C | 1993 | Atomic Data and Nuclear Data Tables1993，54，2： | 1 |
| 12 | Characterization of Phenols and Indanol in Coal Derived Liquids-use of Curie Point Vaporization Gas Chromatography Mass Spectrometry显示文摘 | McClennen W H Henk L C | 1983 | Fuel1983，62，12： | 1 |
| 13 | Ex situ conservation of vegetatively propagated species: Development of a seed-based core collection for Ma!us sieversii 显示文摘 | VOLK M G RICHARDS M C REILLEY A A HENK D A | 2005 | Journal of the American Society for Horticultural Science2005，130，： | 1 |
| 14 | Blood hemoglobin level may affect radiosensitivity, preliminary results on acutely rearing normal tissue显示文摘 | Henke M Bechtold C Momm F | 2000 | Int Radiat Oncol Biol Phys2000，48，： | 1 |
| 15 | Emerging fungal threats to animal,plant and ecosystem health显示文摘 | FISHER M C HENK D A BRIGGS C J | 2012 | Nature2012，484，7396： | 1 |
| 16 | Renal artery aneurysms:diagnosis,management and outcomes显示文摘 | Henke P K Stanley J C | 2003 | Minerva Chir2003，58，： | 1 |
| 17 | Carbon nanotube single-electron transistors at room temperature显示文摘 | Henk W C Postma T T Yao Z | 2001 | Science2001，293，5527： | 1 |
| 18 | X ray interac tions: Photoabsorption, scattering, transmission, and re{lec tion at E=50-30 000 eV, Z--1 92显示文摘 | HENKE B L GULLIKSON E M DAVIS J C | 1993 | Atomic Data and Nu clear Data Table1993，54，2： | 1 |
| 19 | Optimization of 3- (1H-indazol-3-ylmethyl)-1, 5-benzodiazepines as potent, orally active CCK-A agonists 显示文摘 | Henke B R Aquino C J Birkemo L S | 1997 | J Med Chem1997，40，17： | 1 |
| 20 | Mesoporous silica from lyotropic liquid crystal polymer templates显示文摘 | Goltner C G Henke S Weissenberger M C | 1998 | Angew Chem Int Ed1998，37，5： | 1 |
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