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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Mechanical thrombectomy in patients with M1 occlusion and NIHSS score≤5:a single-centre experience显示文摘Background:The recent success of several mechanical thrombectomy trials has resulted in a significant change in management for patients presenting with stroke.However,it is still unclear how to manage patients that present with stroke and low National Institutes of Health Stroke Scale(NIHSS)≤5.We sought to review our experience of mechanical thrombectomy in patients with low NIHSS and confirmed M1 occlusion.Methods:We retrospectively analysed our prospectively maintained database of all patients undergoing mechanical thrombectomy between January 2008 and August 2016.We identified 41 patients with confirmed M1 occlusion and low NIHSS(≤5)on admission to our hospital.We collected demographic,radiological,procedural and outcome data.Results:The mean age of patients was 72±14,with 20 male patients.Associated medical conditions were common with hypertension seen in∼80%.Just over 50%presented with NIHSS 4 or 5.The average ASPECTS score on admission was 8.8(range 6–10),and the average clot length 10 mm.Angiographically Thrombolysis in Cerebral Infarction(TICI)≥2b was obtained in 87.8%of patients.7 patients had haemorrhage on follow-up,2 of which were symptomatic.Of 40 patients with 90-day follow-up,75%had modified Rankin Scale(mRS)score 0–2.There were 3 deaths at 90 days.Conclusions:Mechanical thrombectomy in patients with low NIHSS and proximal large vessel occlusion is technically possible and carries a high degree of success with good safety profile.Patients with low NIHSS and confirmed occlusion should be considered for mechanical thrombectomy. | P Bhogal P Bucke O Ganslandt H Bazner H Henkes M Aguilar Perez | 2016 | Stroke & Vascular Neurology2016，1，4： | 9 |
| 3 | Subcutaneous cervical emphysema and pneumomediastinum due to a lower gastrointestinal tract perforation显示文摘This case report describes a 69-year-old man presen-ting with an extensive subcutaneous emphysema in his neck and generalized peritonitis caused by a lower gastrointestinal tract perforation. This case emphasizes that subcutaneous emphysema patients with negative thoracic findings should be scrutinized for signs of retroperitoneal hollow viscus perforation. | Georg B Schmidt Maarten W Bronkhorst Henk H Hartgrink Lee H Bouwman | 2008 | World Journal of Gastroenterology2008，14，24： | 6 |
| 4 | Gastric cancer显示文摘 | Henk H Hartgrink Edwin PM Jansen Nicole CT van Grieken Cornelis JH van de Velde | 2009 | The Lancet . 2009 (9688)2009，，9688： | 4 |
| 5 | Gastric cancer显示文摘 | Henk H Hartgrink Edwin PM Jansen Nicole CT van Grieken Cornelis JH van de Velde | 2009 | The Lancet2009，，9688： | 2 |
| 6 | Stent-angioplasty of intracranial vertebral and basilar artery stenoses in symptomatic patients 显示文摘 | Weber W Mayer TE Henkes H | 2005 | Eur J Radiol2005，55，2： | 1 |
| 7 | Toxic spongiform leucoencephalopathy after inhaling heroin vapour显示文摘 | Weber W Henkes H Moller P | 1998 | Eur Radiol1998，8，5： | 1 |
| 8 | Development and validation of ultrasound speckle tracking to quantify tendon displacement 显示文摘 | Jan W H K Ruud W S Henk J S | 2012 | Journal of Biomechanics2012，43，7： | 1 |
| 9 | Efficacy of stent angioplasty for symptomatic stenoses of the proximal vertebral artery显示文摘 | Weber W Mayer T E Henkes H | 2005 | Eur J Radiol2005，56，2： | 1 |
| 10 | A novel, self- expanding, nitinol stent in medically refractory intracranial atherosclerotic stenoses: the Wingspan study显示文摘 | Bose A Hartmann M Henkes H | 2007 | Stroke2007，38，5： | 1 |
| 11 | Endovascular coil occlusion of intracranial aneurysms assisted by a novel self-expand- able nitinol mierostent (neuroform)显示文摘 | Henkes H Bose A Felber S Miloslavski E Berg- Dammer E Kuhne D | 2002 | Interv Neuro- radiol2002，8，： | 1 |
| 12 | Branched polyphosphazenes with controlled dimensions 显示文摘 | Henke H Wilfert S lturmendi A | 2013 | Journal of Polymer Science Part A: Polymer Chemistry2013，51，20： | 1 |
| 13 | Pulsed plasma source spectrometry in the 80-8 000 eV X-ray region显示文摘 | Henke B L Yamada H T Tanaka T J | 1983 | Review of Scientific Instruments1983，54，10： | 1 |
| 14 | Treatment of extraer- nial and intraeranial aneurysms and arteriovenous fistulae using stent grafts显示文摘 | Felber S Henkes H Weber W | 2004 | Neurosurgery2004，55，4： | 1 |
| 15 | Does Aller-genspecific immunotherapy represent a thdrapeutic option for patients with atopic dermatitis? 显示文摘 | Bussmann C Bockenhoff A Henke H | 2006 | Allerty clin Immunol2006，118，6： | 1 |
| 16 | Characterization of Phenols and Indanol in Coal Derived Liquids-use of Curie Point Vaporization Gas Chromatography Mass Spectrometry显示文摘 | McClennen W H Henk L C | 1983 | Fuel1983，62，12： | 1 |
| 17 | Chromosomal changes characterize head and neck cancer with poor prognosis显示文摘 | Bauer VL Braselmann H Henke M | 2008 | J Mol Med(Berl)2008，86，12： | 1 |
| 18 | Endovascular therapy of brain AVMs prior to radiosurgery显示文摘 | Nahser HC Berg-Dammer E | 1998 | Neurol Res1998，20，： | 1 |
| 19 | Endovascular management of dural carotid-cavernous sinus fistulas in 141 patients显示文摘 | Henkes H Liebig T | 2006 | Neuroradiology2006，48，： | 1 |
| 20 | A paternity case with three genetic incompatibilities between father and child due to maternal uniparental disomy 21 and a mutation at the Y chromosome显示文摘 | Audrey ML Jurgen H Henke L | 2009 | Forensic Sci Int Genet2009，3，2： | 1 |
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