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| 1 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 2 | A chemical approach to the dielectric aging of fibre-reinforced polymer (FRP)insulators显示文摘 | SCHRIJVER C HERDEN A KRNER H C | 1997 | ETEP1997，7，2： | 1 |
| 3 | Influence of scaffold thickness and scaffold composition on bioartificial graft survival 显示文摘 | Walles T Herden T Haverich A | 2003 | Biomaterials2003，24，7： | 1 |
| 4 | Follicular thyroid cancer treated at the Mayo Clinic, 1946 through 1970: initial manifestations, pathologic findings, therapy, and outcome显示文摘 | Brennan M D Bergstrath E J van Herden J A | 1991 | Mayo Clin Proc1991，66，1： | 1 |
| 5 | Distribution of Borna disease virus in the brain of rats infected with an obesity-inducing virus strain显示文摘 | Herzog S Richt JA | 2000 | Brain Pathol2000，10，1： | 1 |
| 6 | Dynamic contour tonometry (DCT) versus Goldmann applanation tonometry (GAT) - a comparison of agreement and reproducibility显示文摘 | Sonja Herdener Mona Pache Sonja Lautebach Jens Funk | 2006 | Graefe’s Archive for Clinical and Experimental Ophthalmology2006，，7： | 1 |
| 7 | Surgical aspects and outcome of combined liver and kidney transplantation in children显示文摘 | Herden U Kemper M Ganschow R | 2011 | Transpl Int2011，24，8： | 1 |
| 8 | Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer’s disease显示文摘 | Sarah M. Rothman Nathan Herdener Kathryn A. Frankola Mohamed R. Mughal Mark P. Mattson | 2013 | Brain Research2013，，： | 1 |
| 9 | Influence of scaffold thickness and scaffold composition on bioartificial graft survival显示文摘 | Walles T Herden T Haverich A | 2003 | Biomaterials2003，24，7： | 1 |
| 10 | Intrathyroid adeno-mas in primary hyperparathyroidism : are they frequent enoughto guide surgical strategy? 显示文摘 | Herden U Seiler CA Candinas D | 2011 | Surg Innov2011，18，： | 1 |
| 11 | A Chemical Approach to the Dielectric Aging of Fibre-reinforced Polymer (FRP) Insulators显示文摘 | C Schrijver A Herden H C Krner | | ETEP0，7，2： | 1 |
| 12 | Epidural analgesia in colonic surgery: Results of a randomized prospective study显示文摘 | Bredtmann RD Herden HN Teichmann W | 1990 | Br J Surg1990，77，： | 1 |
| 13 | Heart valves from pigs and the porcine endogenous retrovirus: experimental and clinicai data to assess the probability of porcine endogenous retrovirus infection in human subjects 显示文摘 | Moza AK Mertsching H Herden T | 2001 | J Thorac Cardiovasc Surg2001，，： | 1 |
| 14 | High-resolution three dimensional numerical simulation of circulating fluidized bed显示文摘 | Zhang D Z Herden W B | 2001 | Powder Technology2001，116，3： | 1 |
| 15 | Technological interweavement:a means of achieving innovation success显示文摘 | GEMUNDEN H G Heydebreck P Herden R | 1992 | R & D Man1992，22，4： | 1 |
| 16 | Expression of allograft inflammatory factor-1 and haeme oxygenase-1 in brains of rats infected with the neurotropic Boma disease virus显示文摘 | Herden C Schluesener HJ Richt JA | 2005 | Neuropathol Appl Neurobiol2005，31，5： | 1 |
| 17 | 3xTgAD mice ex-hibit altered behavior and elevated Ap after chronic mild socialstress 显示文摘 | Rothman S M Herdener N Camandola S | 2012 | Neurobiol Aging2012，33，4： | 1 |
| 18 | 3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress显示文摘 | Rothman SM Herdener N Camandola S | | 0，，： | 1 |
| 19 | Technological interweavement:A means of achieving innovation success显示文摘 | Gemunden H G Heydebreck P Herden R | 1992 | R&D Management1992，3，： | 1 |
| 20 | 3x Tg AD mice exhibit altered behavior and elevated Aβafter chronic mild social stress显示文摘 | Rothman SM Herdener N Camandola S | 2012 | Neurobiol Aging2012，33，： | 1 |
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