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| 1 | Development of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells显示文摘免疫球蛋白 E (IgE ) 在过敏气喘起一个关键作用并且是为 monoclonal 抗体的一个临床上验证的目标。治疗学的 anti-IgE 抗体块在 IgE 和 Fc epsilon 之间的相互作用(Fcε) 受体,它消除或最小化,但是做过敏显型不典型地由 B 房间削减 IgE 的进行中的生产。我们产生了有潜力抵销可溶的 IgE 并且通过抗体依赖者消除表示 IgE B 房间的高亲密关系的 anti-IgE 抗体(MEDI4212 ) 调停房间的 cytotoxicity。MEDI4212 变体被产生在 fucosylation 在抗体或改变的 Fc 区域包含变化以便为 Fcγ 提高抗体亲密关系; RIIIa。所有 MEDI4212 变体与比得上的亲密关系跳了到人的 IgE 野类型(WT ) 抗体。每变体被显示禁止在 IgE 和 Fcε 之间的相互作用; RI,它翻译了成 Fcγ 的有势力抑制;调停 RI 的功能回答。重要地,所有变体在表示房间的膜 IgE 的表面同样跳了到 IgE。然而, MEDI4212 变体为 Fcγ 表明了提高的亲密关系;包括在位置 158 点的多态的变体的 RIIIa。在 Fcγ 的改进;导致的 RIIIa 绑定在用两个都设计的房间线和类的基于的试金交换了的房间增加了受动器功能人的 IgE B 房间。通过它 IgE 的优异抑制,我们预计那受动器功能提高了 MEDI4212 也许能抵销可溶的 IgE 的高水平并且在他们区分并且变得 IgE secreting 血浆房间以前,由消除表示 B 房间的 IgE 提供增加的长期的利益。 | Andrew C. Nyborg Anna Zacco Rachel Ettinger M. Jack Borrok Jie Zhu Tom Martini Rob Woods Christine Kiefer Michael A. Bowen E. Suzanne Cohenz Ronald Herbst Herren Wu Steven Coats | 2016 | Cellular & Molecular Immunology2016，13，3： | 3 |
| 2 | Beliefs regarding child anxiety and parenting competence in parents of children with separation anxiety disorder显示文摘 | Herren C In-Albon T Schneider S | 2013 | Journal of Behavior Therapy and Experimental Psychiatry2013，44，： | 1 |
| 3 | Arrhythmogenic right ventricular cardiomyopathy/dysplasia:A not so rare 'disease of the desmosome' with multipte clinical presentations显示文摘 | Herren T Gerber PA Duru F | 2009 | Clin Res Cardiol2009，98，3： | 1 |
| 4 | Altered skeletal muscle ultrastructure in renal transplant patients on predni- sone显示文摘 | Horber FF Hoppeler H Herren D | 1996 | Kidney Int1996，30，3： | 1 |
| 5 | A new DNA extraction method for high-thougput marker analysis in a largegenome species such as Triticum aestivum 显示文摘 | Stein N Herren G Keller B | 2001 | Plant Breeding2001，120，： | 1 |
| 6 | The distribution of IL-13 receptor α1 expression on B cells,T cells and monocytes and its regulation by IL-13 and IL-4显示文摘 | Graber P Gretener D Herren S | 1998 | Eur J Immunol1998，28，： | 1 |
| 7 | Anglo- genesis pattern of native and cross-linked collagen membranes: an immunohistochemical study in the rat显示文摘 | Schwarz F Rothamel D Herren M | 2006 | Clin Oral Implants Res2006，17，4： | 1 |
| 8 | Nitro musks, nitro musk amino metabolites and polycyclic musks in sewage sludges Quantitative determination by HRGC-ion-trap-MS/MS and mass spectral characterization of the amino metabolites 显示文摘 | Herren D Berset J D | 2000 | Chemosphere2000，40，： | 1 |
| 9 | TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock显示文摘 | Daubeuf B Mathison J Spiller S Hugues S Herren S Ferlin W | 2007 | J Immunol2007，179，： | 1 |
| 10 | Introduction and spread of the cassava green mite, Mononychellus tanajoa (Bondar) (Acari: Tetranychidae), an exotic pest in Africa and the search for appropriate control methods: a review显示文摘 | Yaninek J S Herren H R | 1988 | Bulletin of Entomological Research1988，78，： | 1 |
| 11 | Characterization of the GGPP synthase gene family in Arabidopsis thaliana 显示文摘 | BECK G COMAN D HERREN E etal | 2013 | Plant Molecular Biology2013，82，45： | 1 |
| 12 | LuxS contributes to virulence in avian pathogenic Escherichia coil 078: K80:H9 显示文摘 | Mitra A Palaniyandi S Herren C D | 2013 | Vet Microbiol2013，166，34： | 1 |
| 13 | Quantitative determination of the den- tal arch by polygon measurement in the ideal and anomalous arch 显示文摘 | Herren P Jordi-Guilloud T | 1973 | SSO Schweiz Monatsschr Zahnheilkd1973，83，6： | 1 |
| 14 | The removal of A1203 particles from grit-blasted titanium implant surfaces: effects on biocompatibility, osseointegration and interface strength in vivo 显示文摘 | ROger M Gensior T J Herren C | 2010 | Acta Biomater2010，6，7： | 1 |
| 15 | A new DNA extraction method for high--throughput marker analysis in a largegenome species such as Triticum aestivu显示文摘 | Stein N Herren G Keller B | 2001 | Plant Breed2001，120，6： | 1 |
| 16 | Surface- and nonsurface- dependent in vitro effects of bone substitutes on cell viability 显示文摘 | Herren M Rothamel D Schwarz F | 2009 | Clin Oral Inwestig2009，13，2： | 1 |
| 17 | Transfer of zinc from xylem to phloem in the peduncle of wheat显示文摘 | Herren T Feller U | 1994 | J Plant Nutri1994，17，： | 1 |
| 18 | Allskiren, an oral reein inhibitor pro- vides dose-dependent efficacy and sustained 24 hour blood pressure control in patients with hypertension 显示文摘 | Oh BH Mitchell J Herren JR | 2007 | J Am Coil Cardiol2007，49，11： | 1 |
| 19 | The call biology plasminogen system显示文摘 | Herren T Redlitz A | 1995 | FAESB J1995，9，： | 1 |
| 20 | Transport of cadmium via xylem and phloem in maturing wheat shoots: comparison with the translocation of zinc, strontium and rubidium 显示文摘 | Herren T Feller U | 1997 | Annals of Botany1997，80，： | 1 |
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