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| 1 | Vitamin D deficiency: Correlation to interleukin-17, interleukin-23 and PⅢNP in hepatitis C virus genotype 4显示文摘AIM: To assess vitamin D (Vit D) abnormalities in hepatitis C infected patients and their relationship with interleukin (IL)-17, IL-23 and N-terminal propeptide of type Ⅲ pro-collagen (PⅢNP) as immune response mediators. METHODS: The study was conducted on 50 Egyptian patients (36 male, 14 female) with hepatitis C virus (HCV) infection, who visited the Hepatology Outpatient Clinic in the Endemic Disease Hospital at Cairo University. Patients were compared with 25 ageand sexmatched healthy individuals. Inclusion criteria were based on a history of liver disease with HCV genotype 4 (HCV-4) infection (as new patients or under followup). Based on ultrasonography, patients were classified into four subgroups; 14 with bright hepatomegaly; 11 with perihepatic fibrosis; 11 with hepatic cirrhosis; and 14 with cirrhosis and hepatocellular carcinoma (HCC).Total Vit D (i.e., 25-OH-Vit D) and active Vit D [i.e., 1,25-(OH) 2 -Vit D] assays were carried out using commercial kits. IL-17, IL-23 and PⅢNP levels were assayed using enzyme linked immunosorbent assay kits, while HCV virus was measured by quantitative and qualitative polymerase chain reaction. RESULTS: Levels of Vit D and its active form were significantly lower in advanced liver disease (hepatic cirrhosis and/or carcinoma) patients, compared to those with bright hepatomegaly and perihepatic fibrosis. IL-17, IL-23 and PⅢNP levels were markedly increased in HCV patients and correlated with the progression of hepatic damage. The decrease in Vit D and active Vit D was concomitant with an increase in viral load, as well as levels of IL-17, IL-23 and PⅢNP among all subgroups of HCV-infected patients, compared to normal healthy controls. A significant negative correlation was evident between active Vit D and each of IL-17, IL-23 and PⅢNP (r = -0.679, -0.801 and -0.920 at P < 0.001, respectively). HCV-infected men and women showed no differences with respect to Vit D levels. The viral load was negatively correlated with Vit D and active Vit D (r = -0.084 and -0.846 at P < 0.001, respectively), and positively correlated with IL-17, IL-23 and PⅢNP (r = 0.951, 0.922 and 0.94 at P < 0.001, respectively). Whether the deficiency in Vit D was related to HCVinduced chronic liver disease or was a predisposing factor for a higher viral load remains to be elucidated. CONCLUSION: The negative correlations between Vit D and IL-17, IL-23 and PⅢNP highlight their involvement in the immune response in patients with HCV-4related liver diseases in Egypt. | Mona F Schaalan Waleed A Mohamed Hesham H Amin | 2012 | World Journal of Gastroenterology2012，18，28： | 12 |
| 2 | MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca^sup 2+^ overload and cell death显示文摘 | Aurora Arin B Mahmoud Ahmed I Luo Xiang Johnson Brett A van Rooij Eva Matsuzaki Satoshi Humphries Kenneth M Hill Joseph A Bassel-Duby Rhonda Sadek Hesham A Olson Eric N | 2012 | EN2012，，4： | 2 |
| 3 | Automated Vision System for Localizing Structure Defects in Textile Fabrics显示文摘 | Abouelela A Hazem M A Hesham E | 2005 | Pattern Recognition Letters2005，26，10： | 1 |
| 4 | Diagnosis of ventilator-associated pneumonia显示文摘 | Andrew RL Syed A Hesham M etal | 2008 | J Criti Care2008，24，3： | 1 |
| 5 | The effective- ness of clomiphene citrate in LH surge suppression in women undergoing IUI: a randomized controlled trial 显示文摘 | Hesham AI Hamdy A Waleed EK | 2010 | Fertil Steril2010，94，6： | 1 |
| 6 | Effects on Cd and Pb on soil microbial community structure and activities 显示文摘 | Khan S Hesham A E Qiao M | 2010 | Envi- ronmental Science and Pollution Research2010，17，： | 1 |
| 7 | Monitoring Changing Position of Coastline Using Thematic Mapper Imagery,an Example From the Nile Delta显示文摘 | Kevin White Hesham M E A | 1999 | Geomorphology1999，29，12： | 1 |
| 8 | Effects of annealing and doping on nanostructured bismuth telluride thick films显示文摘 | LI Shanghua Hesham M A Soliman Jian Zhou | 2008 | Chemistry Materials2008，20，13： | 1 |
| 9 | Global childhood unintentional injury surveillance in four cities in developing countries: a pilot study显示文摘 | Hyder Adnan A Sugerman David E Puvanachandra Prasanthi Razzak Junaid El-Sayed Hesham Isaza Andres Rahman Fazlur Peden Margie | 2009 | Bulletin of the World Health Organization2009，，5： | 1 |
| 10 | Effect of chitosan coating on shelf life and quality on fresh-cut mushroom显示文摘 | Hesham A A Eissa | 2007 | Journal of Food Quality2007，30，5： | 1 |
| 11 | Pest control expert system for tomato (PCEST)显示文摘 | EL-SAYED EL-AZHARY HESHAM A H RAFEA A | 2000 | Knowlegde and Information System2000，2，： | 1 |
| 12 | Automated vision system for localizing structural defects in textile fabrics 显示文摘 | Abouelela A Hazem M A Hesham E d al | 2005 | Pattern Recognition Letters2005，26，10： | 1 |
| 13 | Transient electromagnetic responses of 3D polarizable body显示文摘 | HESHAM M E ESSAM A E | 2004 | Geophysics2004，69，： | 1 |
| 14 | Benzo(a)pyrene,3-methylcholanthrene and β-naphthoflavone induce oxidative stress in hepatoma hepa1c1c7 cells by an AHR-dependent pathway显示文摘 | REEM H ELBEK A I HESHAM M | 2004 | Free Radical Res2004，38，11： | 1 |
| 15 | Radiation-induced grafting of glycidyl methacrylate onto cotton fabric waste and its mod- ification for anchoring hazardous wastes from their solutions显示文摘 | HESHAM H S SAYED M B EHAB M Z et a/ | 2009 | Jour- nal of Hazardous Materials2009，168，1： | 1 |
| 16 | Optimal and approximate approaches for selecting proxy agents in mobile IP based network backbones显示文摘 | KAMAL A HESHAM E R RAZA U M | 2004 | Parallel Distributed Computer2004，，64： | 1 |
| 17 | Application of cleaner production technology in chemical industry: A near zero emission显示文摘 | Sohair I A Hesham A H Enns A T | 2007 | Journal ofCleanerProduction2007，15，18： | 1 |
| 18 | Diagnosis of Ventilator- associated Pneumonia显示文摘 | Andrew RL Syed A Hesham M | 2008 | J Criti Care2008，24，3： | 1 |
| 19 | Biodegradation ability and aatabolic genes of Petroleum- Degrading Sphingomonas koreensis strain ASU-06 isolated from Egyptian Oily soil 显示文摘 | HESHAM A E MAWAD A M M MOSTAFA Y M | 2014 | BioMed Research International2014，2014，12： | 1 |
| 20 | Distributed spectrum sensing with sequential ordered transmissions to a cognitive fusion center显示文摘 | Hesham L Sultan A Nafie M | 2012 | IEEE Transactions on Signal Processing2012，60，5： | 1 |
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